Wisconsin Alzheimer's Disease Research center

威斯康星州阿尔茨海默病研究中心

• 批准号: 10601050
• 负责人: Sanjay Asthana
• 金额: $ 301.38万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601050
• 关键词: Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease patient; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Autopsy; Biochemical; Biological; Biological Markers; Blood; Brain; Caregiver support; Caring; Cells; Cerebrospinal Fluid; Clinical; Clinical Data; Cohort Studies; Collaborations; Communities; Competence; Consultations; County; DNA; DNA Repository; Data; Data Analyses; Data Collection; Data Set; Data Storage and Retrieval; Dementia; Development; Diagnosis; Disease; Disease Progression; Dissemination and Implementation; Doctor of Philosophy; Early Diagnosis; Early treatment; Education and Outreach; Enrollment; Ensure; Evaluation; Exercise; Faculty; Family; Funding; General Population; Genetic; Goals; Health Professional; Health Technology; Heterogeneity; Individual; Informatics; Infrastructure; Institution; International; Leadership; Link; Mentors; Mission; Modeling; Molecular; Native Americans; Nature; Neurobiology; Neurosciences; Oneida; Palliative Care; Participant; Pathologic; Pathology; Patient Care; Patient Recruitments; Patients; Postdoctoral Fellow; Prevention strategy; Process; Recording of previous events; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Role; Safety; Sampling; Seminal; Standardization; Stem Cell Research; Symptoms; Techniques; Telemedicine; Training; Training Support; Underrepresented Minority; Underrepresented Populations; Wisconsin; Work; biomarker discovery; brain tissue; clinical diagnosis; clinical phenotype; clinical practice; collaborative environment; computerized tools; data management; education research; effective therapy; end of life; experience; genetic risk factor; genome wide association study; healthy aging; implementation research; improved; induced pluripotent stem cell; innovation; mHealth; middle age; multidisciplinary; neuroimaging; neuropathology; next generation; novel; outreach; outreach program; pre-clinical; programs; recruit; societal costs; synergism; treatment strategy; vascular risk factor; volunteer; web services

PROJECT SUMMARY - OVERALL The overall goal of the renewal of the Wisconsin Alzheimer's Disease Research Center (ADRC) is to support cutting-edge, innovative research on the pathobiology, early diagnosis and treatment of Alzheimer's disease (AD) and related illnesses. This goal will be accomplished by establishing a stimulating, interdisciplinary environment for collaborative research and providing invaluable clinical data, ante-mortem biospecimens, and autopsy brain tissue. Funded by NIA in 2009, the Wisconsin ADRC will support eight well-integrated Cores, including a new Care Research Core and Research Education Component (REC) that will support timely, innovative research, which will: 1) characterize preclinical biomarkers of AD and their role in predicting transition from preclinical to clinical stages of the disease; 2) investigate the neurobiology of AD; 3) identify novel vascular and genetic risk factors, linking them to the disease pathology and clinical phenotype; 4) incorporate contemporary biochemical and molecular techniques into clinical-pathologic cohort studies, including omics and next generation genetic sequencing; and 5) participate and facilitate the missions of other federal, state and local agency-supported aging and dementia research programs. The overall goals of the Center will be accomplished through coordinated activities of its eight Cores and the REC. The Administrative Core will provide scientific leadership to the ADRC as a whole. The Clinical Core will perform standardized evaluations and collect UDS and additional data on all research participants. It will work closely with the Outreach, Recruitment and Engagement (ORE) Core and the Inclusion of Underrepresented Groups (URG) Core to enhance enrollment of underrepresented minorities. The Data Management and Statistical (DMS) Core will continue to meet all data management, informatics, and statistical needs and support all the PC- and web-based services and processes. The Neuropathology Core will continue to provide neuropathologic diagnoses and process, store, and distribute antemortem biospecimens and postmortem brain tissue to support novel research in AD. The ORE Core will provide a broad-range of educational and outreach programs about AD and the Wisconsin ADRC missions to recruit research volunteers, especially those from URGs into the Clinical Core and other NIA-funded initiatives, such as ADCS, ADNI, NCRAD and GWAS studies. The URG Core will work closely with the ORE and Clinical Cores to enhance recruitment and retention of URG participants into the ADRC. The new Biomarker Core will support and provide access to resources in preclinical neuroimaging and cerebrospinal fluid (CSF) biomarkers of AD. The REC will coordinate closely with the Clinical, ORE, URG, Neuropathology and DMS Cores to provide state-of-the-art, competency-based training to postdoctoral fellows and early-stage faculty in all aspects of aging & dementia research. The new Care Research Core will provide novel expertise and resources to conduct innovative studies that will enhance patient care and change clinical practice.

项目摘要 - 总体 威斯康星州阿尔茨海默氏病研究中心（ADRC）更新的总体目标是支持 关于病理生物学，早期诊断和治疗阿尔茨海默氏病的尖端，创新研究 （AD）和相关疾病。这个目标将通过建立一个刺激的跨学科来实现 合作研究的环境，提供宝贵的临床数据，原态性生物测量和 尸检脑组织。威斯康星州ADRC于2009年由NIA资助，将支持八个整合良好的核心， 包括新的护理研究核心和研究教育部分（REC），该组件将及时支持 创新研究将：1）表征AD的临床前生物标志物及其在预测过渡中的作用 从临床前到疾病的临床阶段； 2）研究AD的神经生物学； 3）识别新型血管 和遗传危险因素，将其与疾病病理和临床表型联系起来； 4）合并 当代生化技术和分子技术用于临床病理队列研究，包括OMICS和 下一代遗传测序； 5）参与并促进其他联邦，州和地方的任务 代理支持的衰老和痴呆症研究计划。该中心的总体目标将实现 通过其八个核心和Rec的协调活动。行政核心将提供科学 整个ADRC的领导。临床核心将进行标准化评估并收集UDS 以及所有研究参与者的其他数据。它将与外展，招聘和 参与（矿石）核心以及代表性不足的群体（urg）核心的核心核心以增强注册 代表性不足的少数民族。数据管理和统计（DMS）核心将继续满足所有 数据管理，信息学以及统计需求并支持所有基于PC和Web的服务以及 过程。神经病理学核心将继续提供神经病理学的诊断和过程， 商店，并分布生物质质生物测量和验尸后脑组织，以支持AD中的新研究。 矿石核心将提供有关广告和广告的广泛教育和外展计划 威斯康星州ADRC的任务招募研究志愿者，尤其是从URGS到临床核心的志愿者和 NIA资助的其他计划，例如ADC，ADNI，NCRAD和GWAS研究。 URG核心将密切工作 借助矿石和临床核心，可以增强URG参与者招募和保留ADRC。这 新的生物标志物核心将支持并提供临床前神经影像学和脑脊髓中资源的访问 AD的流体（CSF）生物标志物。 REC将与临床，矿石，URG，神经病理学和 DMS核心为博士后研究员和早期教师提供最先进的基于能力的培训 在衰老和痴呆研究的各个方面。新的护理研究核心将提供新颖的专业知识和 进行创新研究的资源，以增强患者护理并改变临床实践。

项目成果

Dementia in People with a Turkish Migration Background: Experiences and Utilization of Healthcare Services.

• DOI: 10.3233/jad-200184
• 发表时间: 2020
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Monsees J;Schmachtenberg T;Hoffmann W;Kind A;Gilmore-Bykovskyi A;Kim AJ;Thyrian JR
• 通讯作者: Thyrian JR

Feasibility of a human factors work-system designed recruitment method for hospitalized persons with dementia.

• DOI: 10.1111/jgs.17039
• 发表时间: 2021-04
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Loosen JA;Schmitz EJ;Hermann CL;Troller PJ;Kind AJH
• 通讯作者: Kind AJH

A Quality Improvement Curriculum for Psychiatry Residents.

• DOI: 10.15766/mep_2374-8265.10870
• 发表时间: 2020-01-24
• 期刊: MedEdPORTAL : the journal of teaching and learning resources
• 作者: Reardon, Claudia L;Hafer, Roderick;Walaszek, Art
• 通讯作者: Walaszek, Art

Validity Evidence for the Research Category, "Cognitively Unimpaired - Declining," as a Risk Marker for Mild Cognitive Impairment and Alzheimer's Disease.

• DOI: 10.3389/fnagi.2021.688478
• 发表时间: 2021
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Langhough Koscik R;Hermann BP;Allison S;Clark LR;Jonaitis EM;Mueller KD;Betthauser TJ;Christian BT;Du L;Okonkwo O;Birdsill A;Chin N;Gleason C;Johnson SC
• 通讯作者: Johnson SC

Dysphagia Profiles Among Inpatients with Dementia Referred for Swallow Evaluation.

• DOI: 10.3233/jad-220402
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Wang, Steven;Gustafson, Sara;Deckelman, Celia;Sampene, Emmanuel;Daggett, Sarah;Loosen, Julia;Robison, Raele;Pulia, Michael S.;Knigge, Molly;Thibeault, Susan;Gilmore-Bykovskyi, Andrea;Kind, Amy;Rogus-Pulia, Nicole
• 通讯作者: Rogus-Pulia, Nicole