Aspen Lung Conference: Rebuilding the Injured Lung

阿斯彭肺会议：重建受伤的肺

基本信息

批准号：
8711900
负责人：
David W. Riches
金额：
$ 2万
依托单位：
NATIONAL JEWISH HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2015-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): With an emphasis on the integration of basic, translational and clinical approaches, the 57th annual Thomas L. Petty Aspen Lung Conference will focus on a central question: how can we translate knowledge regarding the mechanisms underlying alveolar injury into effective approaches to rebuild the injured lung? To address this central question, we have organized the conference program into a series of thematic sessions focusing on (i) contemporary understanding of the pathogenic mechanisms underlying acute and progressive lung injury and fibrosis, (ii) conceptual issues centering around the complex interactions between pulmonary epithelial cells, mesenchymal cells, and the surrounding extracellular connective tissue matrix, (iii) current understanding of matrix scaffolds and stem cell biology as approaches to repairing and rebuilding the injured lung, while preventing the development or progression of fibrotic lung disease, and (iv) strategies to translate scientific advances into potential therapies for patients with lung injury and/or fibrosis. By addressing these topics across six thematic sessions, we seek to accomplish the following objectives: 1) To provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding fundamental concepts contributing to lung injury, fibrosis, and repair. 2) To stimulate interactions between the historically-disparate scientific fields of Acute Lung Injury/ARDS and Pulmonary Fibrosis with the goal of identifying emerging, shared interests that may lead to the performance of more efficient and productive research. 3) To enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better implement scientific advances into patient care and by addressing challenges in clinical trial design. 4) To challenge and stimulate the scientific interests of trainees, attracting a new generation of junior investigators into the fields of lung injury and repair.

描述（由申请人提供）：重点是基本，转化和临床方法的整合，第57届年度Thomas L. Petty Aspen肺肺会议将重点介绍一个中心问题：我们如何将有关肺泡损伤基本机制的知识转化为有效方法重建受伤的肺呢？ To address this central question, we have organized the conference program into a series of thematic sessions focusing on (i) contemporary understanding of the pathogenic mechanisms underlying acute and progressive lung injury and fibrosis, (ii) conceptual issues centering around the complex interactions between pulmonary epithelial cells, mesenchymal cells, and the surrounding extracellular connective tissue matrix, (iii) current understanding of matrix scaffolds and stem细胞生物学作为修复和重建受伤的肺部的方法，同时阻止纤维化肺部疾病的发展或进展，以及（iv）将科学进步转化为肺损伤和/或纤维化患者的潜在疗法的策略。通过在六个主题会议上解决这些主题，我们试图实现以下目标：1）为领导基本，转化和临床研究人员提供一个国际论坛，以交换有关导致肺损伤，纤维化，维修和维修的基本概念的想法。 2）刺激急性肺损伤/ARDS的历史悠久的科学领域与肺纤维化之间的相互作用，目的是识别可能导致更有效和生产性研究的出现，共同的兴趣。 3）通过制定新颖的策略来更好地将科学进步实施到患者护理中，并通过应对临床试验设计中的挑战，从而增强了将临床前科学进步转化为直接患者利益的成功的可能性。 4）挑战和刺激学员的科学利益，吸引了新一代的初级研究人员进入肺损伤和修复领域。