Biostatistics and Bioinfomatics Core

生物统计学和生物信息学核心

• 批准号: 8928564
• 负责人: Edie A Weller
• 金额: $ 19.97万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-16 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8928564
• 关键词: Applications Grants; Bioinformatics; Biometry; Characteristics; Clinical Protocols; Clinical Research; Clinical Trials; Collaborations; Computers; Consult; Consultations; Data; Data Analyses; Data Collection; Data Quality; Databases; Development; Education; Funding; Gene Expression; Genomics; Goals; Laboratories; Laboratory Animals; Manuscripts; Mentors; Methods; Multiple Myeloma; Outcome; Patients; Preparation; Procedures; Process; Quality Control; Recommendation; Reporting; Research Personnel; Specialist; career development; computer infrastructure; computerized data processing; data management; design; experience; high throughput analysis; member; quality assurance; research study; success

The purpose of the Biostatistics and Bioinformatics Core C is to provide consultation and collaboration on quantitative methods on all SPORE Projects, Developmental Projects, and Cores A and B. Successful collaboration between the project leaders and the biostatisticians and computational biologists in this SPORE, as well as members of the other Cores, is essential to achieve the goals of the projects. Members of this core will provide support for the design, analysis, and reporting of laboratory, animal, translational, genomic, and clinical studies. Depending on the project, these collaborations could range from short consultations to large collaborative projects, and will include assistance in preparation of grant applications and manuscripts related to the SPORE projects. The Core members will also provide statistical mentoring to the researchers, with a particular emphasis on Career Development Awardees and Developmental Project Investigators. Important for the success of the SPORE is the coordination of data management and quality control procedures. The biostatisticians and computational biologists are an integral part of this process at the DFCI, and will continue to provide input on the existing procedures, as well as recommendations on additional computational infrastructure, which might be necessary for this SPORE. To achieve the goals of the SPORE, we propose the following specific aims: Specific Aim 1. To provide biostatistical collaboration for SPORE Projects, Developmental Projects, and Cores. This includes all aspects of design, conduct, analysis, and reporting of laboratory and clinical protocols, including coordination of laboratory results with patient characteristics and outcomes from the clinical studies. Specific Aim 2. To provide consulting and statistical education to SPORE researchers. Specific Aim 3. To provide or recommend supporting computational infrastructure. This includes collaboration with the multiple myeloma clinical research coordinators (CRC) and the data specialist at the Quality Assurance Office for Clinical Trials (QACT) on the collection of data, forms development, data processing, and quality assurance of clinical trials data. We will also provide consultation on computer databases, moving data between data bases for laboratory, animal, and relevant clinical studies Specific Aim 4. To provide bioinformatic support for analysis of high throughput transcriptional and genomic studies.

生物统计学和生物信息学核心 C 的目的是提供咨询和合作 对所有 SPORE 项目、开发项目以及核心 A 和 B 进行定量方法。成功 项目负责人与生物统计学家和计算生物学家之间的合作 SPORE 以及其他核心成员对于实现项目目标至关重要。会员 该核心将为实验室、动物、转化、 基因组和临床研究。根据项目的不同，这些合作的范围可能很短 大型合作项目的咨询，并将包括协助准备赠款申请 以及与 SPORE 项目相关的手稿。核心成员还将提供统计指导 研究人员，特别关注职业发展获奖者和发展项目 调查人员。 SPORE 成功的重要因素是数据管理和质量的协调 控制程序。生物统计学家和计算生物学家是这一过程中不可或缺的一部分。 DFCI，并将继续就现有程序提供意见，并就以下方面提出建议： 额外的计算基础设施，这可能是这个 SPORE 所必需的。为了实现以下目标 对于 SPORE，我们提出以下具体目标： 具体目标 1. 为 SPORE 项目、发展项目和 核心。这包括实验室和临床的设计、实施、分析和报告的所有方面 协议，包括实验室结果与患者特征和结果的协调 临床研究。 具体目标 2. 为 SPORE 研究人员提供咨询和统计教育。 具体目标 3. 提供或推荐支持性计算基础设施。这包括协作 与多发性骨髓瘤临床研究协调员 (CRC) 和质量中心的数据专家一起 临床试验保证办公室 (QACT) 负责数据收集、表格开发、数据处理、 以及临床试验数据的质量保证。我们还将提供有关计算机数据库、移动 实验室、动物和相关临床研究数据库之间的数据 具体目标4.为高通量转录和基因组分析提供生物信息学支持 研究。