Drugs, Drug Targets and You: Exploring the Molecular Mechanisms of Drug Abuse wit

药物、药物靶点和你：探索药物滥用的分子机制

基本信息

批准号：
8849879
负责人：
Tim M. Herman
金额：
$ 18.31万
依托单位：
MILWAUKEE SCHOOL OF ENGINEERING
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8849879
关键词：
3D Print Action Potentials Active Sites Amino Acid Sequence Behavior Binding Biological Sciences Cells Chemistry Complement Complex Computers Control Groups Country Development Drug Targeting Drug abuse Drug effect disorder Drug usage Economics Educational process of instructing Environment Evaluation Event Faculty Workshop Goals High School Faculty High School Student Imagery Investigation Knowledge Learning Measures Modeling Molecular Motivation Nervous system structure Neurons Neurosciences Pharmaceutical Preparations Physics Play Process Proteins Recruitment Activity Research Design Role Science Shapes Signal Transduction Staging Students Synapses Tactile Teacher Professional Development Technology Thinking Training Visual Wit addiction base cohort design drug abuse education experience high school innovation neurotransmission physical model research study small molecule teacher tool training project

项目摘要

DESCRIPTION (provided by applicant): Drugs, Drug Targets and You is a multi-faceted project aimed at engaging high school students in an active exploration of the molecular basis of drug use and its consequences on their bodies. Through the use of a variety of innovative, student-centered instructional tools, the project will engage students in an active investigation o how drugs - small molecules with defined 3D shapes - bind to specific active sites on target proteins to modify their normal function in the neurotransmission of signals that control our every thought and action. To insure the usefulness of these instructional tools in high school classrooms, we use a backwards design process in which (i) carefully articulated learning goals drive the development of each instructional tool, and (ii) each learning goal is explicitly tied toa fundamental, foundational concept in the life sciences. As a result, students using these materials become actively engaged in constructing their own knowledge of the molecular consequences of drug use, as they layer this understanding onto foundational concepts of chemistry and physics. This project will complement and enhance currently existing instructional materials by drawing students into an active exploration of the topic using student-centered instructional tools, including: (i) physical models of drugs and the proteins to which they bind (created by 3D printing technologies), (ii) hands-on construction kits in which students create a model of a synapse or the action potential generated in a neuron and (iii) unique cellular landscapes that present these drug target proteins in their cellular context, and transition students' thinking from the macroscopic - to the cellular - to the molecular level. The use of these unique visual and tactile instructional tools then leads to the use of interactive computer-based visualization tools that build upon the initial concepts established with the hands-on tools, and allow for the exploration of more sophisticated concepts in the computer environment. We will study the impact of this molecular approach to drug abuse education using a quasi-experimental study design in which two matched cohorts of high school teachers are trained to use the materials in their classrooms. Finally, in the later stages of this project, we will engage 9,000 high school students in 48 states in a consideration of the molecular consequences of drug use as they participate in a Protein Modeling event as part of the national Science Olympiad competition.

描述（由申请人提供）：药物，药物靶标，您是一个多方面的项目，旨在使高中生积极探索药物使用的分子基础及其对身体的后果。通过使用各种以学生为中心的创新教学工具，该项目将吸引学生进行积极的研究o o如何与定义的3D形状的小分子如何结合目标蛋白上的特定活性位点，以在信号的神经传递中修改其正常功能，以控制我们的每一个思想和动作。为了确保这些教学工具在高中教室中的有用性，我们使用一个向后的设计过程，在该过程中，（i）仔细表达的学习目标推动了每个教学工具的开发，并且（ii）每个学习目标都明确绑定了TOA TOA基本的基础，生命科学的基础概念。结果，使用这些材料的学生积极参与建立自己对药物使用的分子后果的了解，因为他们将这种理解分解到化学和物理学的基本概念上。该项目将通过以学生为中心的教学工具吸引学生进行积极探索该主题的现有教学材料，包括：（i）药物的物理模型和与其束缚的蛋白质（由3D打印技术创建），（ii）动手施工套件，在该工具中产生的comptions或在其中创建的complins in a nortul in a Printins和III III的动作（III II II III）（III II II III）（III II III）（III II III）（III II III）（III II II III）（上下文以及过渡学生从宏观到细胞到分子水平的思维。然后，这些独特的视觉和触觉教学工具的使用会导致使用基于交互式计算机的可视化工具，这些工具建立在用动手工具建立的初始概念上，并允许在计算机环境中探索更复杂的概念。我们将使用准实验研究设计来研究这种分子方法对药物滥用教育的影响，其中对两名匹配的高中教师进行了培训，可以在其教室中使用这些材料。最后，在该项目的后期，我们将参与考虑到美国国家科学奥林匹克竞赛的一部分，在48个州的9,000名高中学生在参与蛋白质建模事件时的分子后果。