Core D: Research Support (Anderson)

核心 D：研究支持（安德森）

• 批准号: 8695376
• 负责人: Kim A. Anderson
• 金额: $ 32.41万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695376
• 关键词: Adoption; Analytical Chemistry; Anus; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biological Markers; Chemicals; Chemistry; Collaborations; Collection; Communities; Complex; Data; Data Set; Development; Devices; Environment; Evaluation; Feedback; Genome; Health; Instruction; Investigation; Isomerism; Laboratories; Methods; Online Systems; Recording of previous events; Relative (related person); Research; Research Personnel; Research Support; Risk; Sampling; Signal Recognition Particle; Superfund; System; Techniques; Testing; Work; analytical method; analytical tool; base; chemical standard; method development; molecular mass; new technology; programs; remediation; repository; screening

PROJECT SUMMARY (See instructions): The research and regulatory communities acknowledge the need to develop analytical methods for PAHs and substitute PAHs (x-PAHs). The recent US EPA IRIS 2010 document Development of a Relative Potency Factory (RFP) Approach for Polycyclic Aromatic Hydrocarbon Mixtures says, "While whole mixture assessment is preferred . . . chemical analysis of the components of mixtures is limited . . . The RPF approach is limited by the small number of PAHs for which there are analytical chemistry." It is challenging to analyze PAHs and x-PAHs in environmental and biological matrices because the samples are complex, the numerous isomers of alkylated and high-molecular-mass compounds are often difficult to differentiate, and we often lack standards and suitable reference materials. We will provide rapid chemical screening and quantitative analysis of mixtures from applicable matrices. The Chemistry Core provides Superfund Center Investigators with critical specialized analytical expertise. We will develop advanced techniques and methods for PAHs and mixtures. The need for new analytical methods continues to top the list of data gaps cited by agency workgroups. We need to further develop our 1,201 analyte screening method to "know thy environment" paralling the genome "know thyself technical advances. We will continue to develop a synthesis unit to make chemical standards that are not commercially available. We enable the work of our biomedical projects by synthesizing PAH metabolites. We plan to expand our synthesis component to include PAHs and substituted PAHs that are not currently commercially available. The lack of commercial standards constitutes a critical barrier to analytical method development and subsequent biomedical testing. We will continue to develop a centralized repository for exposure-based mixture reference materials, standards, and passive sampling devices. We propose to develop new Superfund reference materials, including bioavailable Superfund based materials and pre-and post-remediation extracts. We will make these well-characterized mixtures available to SRP investigators. We will also prepare and distribute passive sampling devices to SRP investigators and US EPA project managers for pilot investigations and evaluation.

项目摘要（请参阅说明）： 研究和监管社区承认有必要开发PAH的分析方法并替代PAHS（X-PAHS）。最近的美国EPA IRIS 2010年的《多环芳族芳烃混合物》的相对效力工厂（RFP）方法的开发说：“虽然首选整个混合物评估……对混合物组件的化学分析是限制的……RPF方法受到RPF方法的限制。在环境和生物矩阵中分析PAH和X-PAH是一项挑战，因为样品很复杂，众多烷基化和高分子质量化合物的异构体通常很难区分，而且我们通常缺乏标准和合适的参考材料。我们将对适用矩阵的混合物进行快速化学筛选和定量分析。化学核心为超级基金中心研究人员提供了关键的专业分析专业知识。我们将开发用于PAH和混合物的先进技术和方法。对新的分析方法的需求继续是代理工作组引用的数据差距列表。我们需要进一步开发我们的1,201个分析物筛选方法，以“了解您的环境”类似于基因组的“知道自己的技术进步”。我们将继续开发一个合成单元，以使无法在商业上可用的化学标准单元。我们启用生物医学项目的工作。我们的生物医学项目的工作是通过合成Pah emabolite的杂物来扩展的。商业标准构成了分析方法开发的关键障碍，随后的生物医学测试将继续开发用于基于暴露的混合物参考材料，标准和被动抽样设备的集中式储存库。向SRP调查人员和美国EPA项目经理分发被动抽样设备，以进行试点调查和评估。