Refinement and Expansion of the Palliative Care Research Cooperative Group (PCRC)

姑息治疗研究合作小组 (PCRC) 的完善和扩大

基本信息

批准号：
8926710
负责人：
JEAN S KUTNER
金额：
$ 183.94万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-28 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8926710
关键词：
Address Applications Grants Area Behavior Therapy Behavioral Research Caregivers Caring Clinical Clinical Research Clinical Trials Communities Data Development Disease Environment Epidemiology Evolution Funding Future Goals Gold Grant Health Health Services Information Systems Institute of Medicine (U.S.)Intention International Investments Knowledge Letters Life Measures Methodology Methods Outcome Palliative Care Patients Phase Population Principal Investigator Procedures Reporting Research Research Design Research Infrastructure Research Personnel Research Priority Research Support Research Training Resources Risk Role Sampling Science Site Staging Structure System Training Work advanced disease behavioral outcome biobehavior design effectiveness research end of life evidence base improved innovation interest patient oriented research study

项目摘要

DESCRIPTION (provided by applicant): In 2010, the Palliative Care Research Cooperative Group (PCRC) was developed as a national collaborative research network to become the scalable, supportive structure so critically needed for the conduct of high quality clinical trials Work proposed under the current grant will build on the accomplishments achieved during the initial NINR funding for the PCRC (UC4NR012584). The overarching objective of this U24 grant application is to amplify the role of the PCRC as a national resource for efficient conduct of high quality, collaborative, multisite, palliative care and end-of-life (PCEOL) research by leveraging and building upon the prior NINR investment and accomplishments of the PCRC to date. The steps planned for further PCRC development will enable it to: (1) support research and develop expertise in understudied PCEOL areas such as caregiver and bio-behavioral research; (2) facilitate efficient and expeditious conduct of important, cutting-edge studies that require large samples and multiple sites; (3) prepare future researchers to utilize and sustain the enterprise, while continuing to build the PCEOL evidence base, and; (4) describe, quantify, and understand the risks, issues, and impact of life-limiting disease on multiple relevant outcomes including health outcomes for patients and caregivers and bio-behavioral interventions and outcomes. Specifically, we propose to rapidly increase the capacity of the PCRC to develop and conduct a diversified portfolio of high quality research studies that are responsive to key gaps in the scientific knowledge. We will achieve these goals through the following specific aims: (1) develop a national research capacity for collaborative, multisite, PCEOL research in a way that maximizes the quality and efficiency of research and the effectiveness of cooperative groups; and (2) provide integrated support for PCEOL research, specifically, for the conduct, analysis, and dissemination of clinically meaningful, high-quality, efficient, patient-centered, multisite studies. The combined result of achieving these aims will be a highly efficient, adaptive, and standardized system to advance prioritized, innovative, rigorously designed and performed, studies in PCEOL research, with a particular emphasis on clinical trials requiring multiple recruitment sites. RELEVANCE: The Palliative Care Research Cooperative Group (PCRC) addresses national research priorities in palliative care and end-of-life (PCEOL) through enhancing efficient conduct and dissemination of high-quality, collaborative, multisite, PCEOL research. The result of achieving the PCRC aims will be a highly efficient, adaptive, and standardized system to advance prioritized, innovative, rigorously designed and performed PCEOL studies that will ultimately enhance and improve care for people with serious and life limiting illnesses.

描述（由申请人提供）：2010 年，姑息治疗研究合作小组 (PCRC) 发展成为一个国家合作研究网络，成为开展高质量临床试验所急需的可扩展的支持性结构。赠款将建立在 PCRC 最初 NINR 资助 (UC4NR012584) 期间取得的成就的基础上。这项 U24 赠款申请的总体目标是扩大 PCRC 作为国家资源的作用，以有效开展高通过利用和建立 PCRC 迄今为止的 NINR 投资和成就，开展高质量、协作性、多地点、姑息治疗和临终关怀 (PCEOL) 研究。 PCRC 进一步发展的计划步骤将使其能够：(1) 支持研究并开发未充分研究的 PCEOL 领域的专业知识，例如护理人员和生物行为研究； (2) 促进高效、迅速地开展需要大样本、多地点的重要前沿研究； (3) 为未来的研究人员利用和维持该企业做好准备，同时继续建立 PCEOL 证据基础； (4) 描述、量化和理解生命限制疾病对多种相关结果的风险、问题和影响，包括患者和护理人员的健康结果以及生物行为干预和结果。具体来说，我们建议迅速提高 PCRC 开发和开展多样化高质量研究的能力，以应对科学知识的关键差距。我们将通过以下具体目标来实现这些目标：（1）以最大限度提高研究质量和效率以及合作小组有效性的方式，发展国家合作、多地点、PCEOL 研究能力； (2) 为 PCEOL 研究提供综合支持，特别是进行、分析和传播有临床意义的、高质量、高效、以患者为中心的多中心研究。实现这些目标的综合结果将是一个高效、适应性和标准化的系统，以推进 PCEOL 研究中优先考虑的、创新的、严格设计和执行的研究，特别强调需要多个招募地点的临床试验。相关性：姑息治疗研究合作小组 (PCRC) 通过加强高质量、协作性、多地点 PCEOL 研究的有效开展和传播，解决姑息治疗和临终关怀 (PCEOL) 方面的国家研究重点。实现 PCRC 目标的结果将是建立一个高效、适应性和标准化的系统，以推进优先、创新、严格设计和执行的 PCEOL 研究，最终将加强和改善对患有严重和生命限制疾病的患者的护理。