Point-of-Care End-Tidal Carbon Monoxide Measurement to Screen for Sickle Cell Disease

床旁潮气末一氧化碳测量可筛查镰状细胞病

• 批准号: 8839680
• 负责人: Anish Bhatnagar
• 金额: $ 21.99万
• 依托单位: SOLENO THERAPEUTICS, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-03 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8839680
• 关键词: Accounting; Adult; Affect; Africa; Algorithms; Anemia; Antibiotics; Birth; Blood Tests; Blood specimen; Cannulas; Carbon Monoxide; Caring; Catabolism; Child; Country; Detection; Developing Countries; Devices; Diagnosis; Diagnostic tests; Disease; Early Diagnosis; Enrollment; Environment; Erythrocytes; Exhalation; Financial compensation; Gases; General Practices; Health education; Healthcare; Heme; Hemolysis; Hemolytic Anemia; High Prevalence; High temperature of physical object; Home environment; Hospitals; Human Resources; Humidity; Hydrogen; India; Infant; Inherited; Laboratories; Life; Live Birth; Measurement; Measures; Medical; Modeling; Modification; Monitor; Neonatal Screening; Newborn Infant; Nose; Output; Oxygen; Pediatric Hospitals; Performance; Phase; Populations at Risk; Porphyrins; Power Sources; Primary Health Care; Process; Public Health; Research; Research Infrastructure; Resources; Sampling; Sickle Cell Anemia; Signal Transduction; Small Business Innovation Research Grant; Solutions; Staging; System; Techniques; Technology; Temperature; Testing; Training; United States; Vaccination; Western Africa; abstracting; arm; base; commercial application; cost; design; disorder control; hemoglobin polymer; improved; infancy; innovation; mortality; point of care; point-of-care diagnostics; programs; prophylactic; public health relevance; screening; sensor; technological innovation; tool

 DESCRIPTION (provided by applicant): Sickle cell disease (SCD) is an inherited anemia in which formation of hemoglobin polymer causes destruction of the red blood cells, a process called hemolysis. SCD is recognized as a significant global public health problem. Over 90% of the 300,000 annual births with SCD occur in resource-poor countries, and most of the affected children die from preventable causes. Thus, there exists an urgent need for technologies to screen infants for SCD so that appropriate health care measures can be initiated. The aim of this proposal is to develop a robust point-of-care diagnostic system based upon measurement of breath carbon monoxide (CO) level. CO in exhaled breath is largely derived from the oxygen-dependent catabolism of heme during destruction of red blood cells, a process accelerated in SCD. Capnia has a device, CoSense", which is currently cleared by the FDA for End-Tidal Carbon Monoxide (ETCO) monitoring. The use of end-tidal breath samples allows the measurement of exhaled CO in young children who cannot provide a forced breath sample. A recent preliminary study demonstrated that ETCO levels measured by CoSense were 6-fold higher in SCD than the controls. Therefore, CoSense, as a screening tool, may be extremely helpful in identifying infants with SCD in resource-poor countries where newborn screening is not available. In Phase I of the SBIR proposal, the current device will be modified to extend its temperature operating range.

 描述（由适用提供）：镰状细胞病（SCD）是一种遗传性贫血，其中血红蛋白聚合物的形成会导致红细胞的破坏，这一过程称为溶血。 SCD被认为是重大的全球公共卫生问题。在资源贫乏的国家中，有30万次患有SCD的年龄中有90％以上，大多数受影响的儿童死于可预防的原因。这迫切需要技术筛查婴儿的SCD，以便可以启动适当的医疗保健测量。 The aim of this proposal is to develop a robust point-of-care diagnostic system based upon measurement of breath carbon monoxide (CO) level.呼出的呼吸中的CO很大程度上源自红细胞破坏时血红素的氧依赖性分解代谢，这一过程在SCD中加速了。 Capnia具有一种设备，“ COSENSE”，目前由FDA清除终止潮汐碳一氧化碳（ETCO）监测。使用末端潮气样品可以测量无法提供强制性呼吸样品的年幼儿童过期的CO。最近的初步研究表明，通过Crosesense的eTCO水平高于SCD，因此，由于SCD的范围更高。在没有新生儿筛查的资源较低的国家中，在SBIR提案的第一阶段进行筛查，将修改该设备以扩展其温度工作范围。