US-UK Collab: RCN: Vector Behavior in Transmission Ecology (VectorBiTE)

美英合作：RCN：传播生态学中的媒介行为 (VectorBiTE)

• 批准号: 9036605
• 负责人: Leah Renee Johnson
• 金额: $ 11.28万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-20 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9036605
• 关键词: Agriculture; Animals; Behavior; Behavioral; Code; Collaborations; Complex; Data; Data Collection; Data Set; Databases; Development; Disease; Ecology; Educational workshop; Evolution; Heterogeneity; Human; Infection; Information Dissemination; Insect Vectors; Institution; Investigation; Link; Longevity; Medical; Methods; Modeling; Plants; Research; Research Personnel; Resistance; Role; Statistical Methods; System; Testing; Theoretical model; Training; Validation; Variant; Vector-transmitted infectious disease; Work; climate change; disease transmission; improved; life history; meetings; novel strategies; public health relevance; response; role model; symposium; tool; trait; transmission process; vector

 DESCRIPTION (provided by applicant): The Vector Behavior in Transmission Ecology Research Coordination Network (VectorBiTE RCN) will facilitate investigation into the role of vector behavior and life history in disease transmission dynamics. The proposed work aims to accomplish this by promoting (1) the development of theoretical models that include more details of vector behavior and heterogeneity; (2) improved data collection and statistical methods to enable such models to be confronted with data; (3) development of comprehensive and freely available validation datasets to allow testing of methods and comparison between proposed models in a transparent fashion; and (4) training of young researchers in these new tools and methods as they are developed. These objectives will be accomplished through: (A) annual meetings and workshops to bring together empirical and theoretical biologists across diverse systems and institutions; (B) the development of an online platform with repositories for data on vector behavior and code for modeling the role of behavior on transmission dynamics; and (C) providing opportunities to educate fellow researchers and the public about network advances via online and conference presentations. Intellectual Merit: Complex vector behaviors and life history traits are often expressed as fixed values in models and do not vary over vector lifespan, with vector infection status or condition, or in response to environmental variation. There is mounting empirical evidence that vector behavioral ecology does vary across all of these scales. However, tools to incorporate this variability to understand transmission dynamics are lacking. This gap presents key questions such as: Do altered behaviors in infected vectors alter disease dynamics? What conditions promote transmission and how will globalization and climate change alter the distribution and intensity of vector borne diseases? Which control strategies might minimize the evolution of transmission/resistance? Understanding the dynamics of these diseases across medical, wildlife, veterinary, and agricultural settings, requires determining whether this variation is important for explaining dynamics. This RCN will facilitate collaborations to develop new approaches linking vector ecology with transmission.

 描述（由应用程序提供）：传播生态研究协调网络中的矢量行为（VectorBite RCN）将促进对向量行为和生活历史在疾病传播动态中的作用的研究。拟议的工作旨在通过促进（1）开发理论模型的发展来实现这一目标，这些模型包括更多有关向量行为和异质性的细节； （2）改进了数据收集和统计方法，使这些模型能够面对数据； （3）开发全面且免费的可用验证数据集，以允许以透明的方式对方法进行测试和比较； （4）在开发这些新工具和方法中对年轻研究人员进行培训。这些目标将通过以下方式实现：（a）年度会议和研讨会，以将潜水员系统和机构的经验和理论生物学家汇集在一起​​； （b）开发具有有关向量行为和代码的数据存储库的在线平台，以建模行为在传输动力学中的作用； （c）通过在线和会议演示文稿提供机会，向研究人员和公众提供有关网络进步的机会。智力优点：复杂的矢量行为和生活历史特征通常以固定值表示，并且在矢量寿命，矢量感染状态或状态或响应环境变化时不会变化。有越来越多的经验证据表明，载体行为生态学在所有这些量表中确实有所不同。但是，缺乏结合这种可变性以了解传输动态的工具。此差距提出了关键问题，例如：感染媒介的行为改变会改变疾病动态吗？什么条件促进传播？全球化和气候变化将如何改变向量传播疾病的分布和强度？哪种控制策略可能最大程度地减少了传输/阻力的演变？了解这些疾病在医疗，野生动植物，兽医和农业环境中的动态，需要确定这种变化对于解释动态是否重要。该RCN将促进合作，以开发将媒介生态与传输联系起来的新方法。