Exposure pathways and mental health impact of PFAS-contaminated biosolids
PFAS 污染的生物固体的暴露途径和心理健康影响
基本信息
- 批准号:10747241
- 负责人:
- 金额:$ 43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-10 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAffectAgricultureAnimalsAnxietyAreaAttenuatedBackBehaviorBody CompositionChemicalsCommunitiesConsumptionDataDeerDiagnosisEatingEnvironmental EpidemiologyEnvironmental ProtectionExploratory/Developmental GrantExposure toFertilizersFinancial HardshipFishesFoodGoalsHealthHouseholdIndividualIntakeInterventionKnowledgeLearningMaineMeasurementMeasuresMental HealthMilkNational Health and Nutrition Examination SurveyPaperParticipantPatient CarePerceptionPilot ProjectsPlantsPoly-fluoroalkyl substancesPopulationPrivatizationQuestionnairesReportingResearch PriorityResistanceRiskRuralRural CommunitySentinelSerumSiteSocial PsychologySoilSourceStainsStatutes and LawsStigmatizationSumTestingTimeWaterWater consumptionWorkagricultural communitycardiovascular disorder riskclinical carecohortcontaminated watercopingdrinking watereggexposure pathwayfarmermeetingspromote resiliencerecruitsocial stigmauptakewell water
项目摘要
PROJECT ABSTRACT
Per- and polyfluoroalkyl substances (PFAS) are persistent “forever chemicals” that make paper and other
products stain resistant, but also contaminate water and food and are detectable in almost every individual in
the US. An understudied exposure source is farmland throughout the rural US where PFAS-contaminated
biosolids are applied as fertilizer. Incomplete information about non-water exposure pathways leaves affected
communities, many of whom are dependent on local agriculture and game for work and food, uncertain how to
minimize exposure. PFAS-contaminated biosolids threaten the livelihoods and food sources of these agrarian
communities, as plant and wildlife exposure to PFAS from biosolids makes selling and consuming local
produce, animal products, or wild fish and game no longer safe. Maine has the unique capability to investigate
these issues because of 2021 state legislation that mandated PFAS testing on land with prior or ongoing
application of biosolids. One sentinel site, the town of Fairfield, was found to have PFAS up to the 1000’s
mg/kg in soil and 30,000’s ng/L in drinking water from private wells—far above local and national health
advisories (EPA’s drinking water advisory is 0.004 ng/L for PFOA). As of now, there are enough impacted
individuals across central Maine [319 wells with PFAS above the Maine health advisory (sum of 6 legacy PFAS
≥ 20 ng/L)] to establish a cohort to guide other communities affected by biosolids across the US. In this study,
our objective is to recruit 300 adults at risk of exposure to PFAS from biosolids to (1) quantify PFAS
concentrations in serum, (2) evaluate water and non-water exposure pathways, and (3) characterize
associations of PFAS with anxiety and perceptions of health risk and stigmatization. The time-sensitive R21
mechanism will allow us to obtain an immediate assessment of serum PFAS levels, which is critical because
some affected individuals learned of the contamination and had a water filter installed up to 2 years ago. PFAS
have long half-lives (3-8 years depending on the compound), and serum measures up to 2 years post-clean
water will be consistent with other community contamination cohorts. To minimize recall bias, it is also
imperative before more time elapses to assess water intake, other potential exposure pathways, and anxiety
and perceptions of health risk/stigmatization before and after knowledge of the contamination. Our
interdisciplinary team has expertise in environmental epidemiology, clinical care of patients with PFAS
exposure, and social psychology. We will partner with the community through a community advisory board,
context-rich report back of individual results, and presentation of aggregated study results at town hall
meetings. We will be the first to our knowledge to establish a cohort with PFAS exposure from biosolids, and
our results will help to generate exposure mitigation advice and interventions to build resilience among
individuals living in communities impacted by PFAS-contaminated biosolids.
项目摘要
全氟烷基物质和多氟烷基物质 (PFAS) 是持久性的“永久化学品”,可用于制造纸张和其他材料。
产品耐污,但也会污染水和食品,并且在几乎每个人身上都可以检测到
美国未被充分研究的暴露源是美国农村地区受 PFAS 污染的农田。
生物固体用作肥料,有关非水暴露途径的信息不完整,导致受影响。
社区,其中许多人依赖当地农业和狩猎来获得工作和食物,但不确定如何
最大限度地减少受 PFAS 污染的生物固体对这些农民的生计和食物来源的威胁。
社区,因为植物和野生动物接触生物固体中的 PFAS 导致在当地销售和消费
缅因州拥有调查不再安全的农产品、动物产品或野生鱼类和野味的独特能力。
这些问题是由于 2021 年州立法强制要求在先前或正在进行的土地上进行 PFAS 测试
费尔菲尔德镇这一哨点被发现含有高达 1000 的 PFAS。
土壤中的毫克/千克和私人水井饮用水中的 30,000 纳克/升——远高于当地和国家的健康水平
公告(EPA 的饮用水公告中 PFOA 含量为 0.004 ng/L)。到目前为止,受影响的地区已经足够多了。
缅因州中部地区的个人 [319 口井的 PFAS 高于缅因州健康建议(6 种遗留 PFAS 的总和)
≥ 20 ng/L)] 建立一个队列来指导美国各地受生物固体影响的其他社区。
我们的目标是招募 300 名有接触生物固体中 PFAS 风险的成年人,以 (1) 量化 PFAS
血清中的浓度,(2) 评估水和非水暴露途径,以及 (3) 表征
PFAS 与焦虑、健康风险认知和污名化的关联 时间敏感的 R21。
机制将使我们能够立即评估血清 PFAS 水平,这一点至关重要,因为
一些受影响的人在两年前就知道了这种污染,并安装了 PFAS 水过滤器。
半衰期长(3-8 年,具体取决于化合物),血清在清洁后可测量长达 2 年
水将与其他社区污染群体保持一致,以尽量减少回忆偏差。
在花更多时间之前必须评估饮水量、其他潜在暴露途径和焦虑
以及了解污染前后对健康风险/污名化的看法。
跨学科团队拥有环境流行病学、PFAS 患者临床护理方面的专业知识
我们将通过社区咨询委员会与社区合作,
背景丰富的个人结果报告,并在市政厅展示汇总研究结果
据我们所知,我们将是第一个建立生物固体中 PFAS 暴露队列的会议。
我们的结果将有助于提出缓解暴露的建议和干预措施,以增强人们的抵御能力
生活在受 PFAS 污染的生物固体影响的社区中的个人。
项目成果
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