Effects of perfluoroalkyl chemicals on stroke incidence, mortality and morbidity

全氟烷基化学品对中风发病率、死亡率和发病率的影响

• 批准号: 8663444
• 负责人: Stephanie J Frisbee
• 金额: $ 29.8万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8663444
• 关键词: Accounting; Acids; Address; Affect; Ancillary Study; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cerebrospinal Fluid; Cerebrovascular Disorders; Chemical Exposure; Chemicals; Chronic Disease; Cohort Studies; Complex; Conflict (Psychology); Detection; Development; Economic Burden; Enrollment; Environment; Evaluation; Exposure to; Faculty; Food Container; Funding; Goals; Health; Heavy Metals; Homocysteine; Homocystine; Human; Hypertension; Incidence; Knowledge; Life; Mediating; Mentors; Morbidity - disease rate; National Institute of Environmental Health Sciences; Outcome; Patient Self-Report; Population; Prevention strategy; Public Health; Recommendation; Reporting; Research; Risk; Risk Factors; Rodent Model; Role; Severities; Staining method; Stains; Stroke; Surface; Survivors; Textiles; Thyroid Function Tests; United States National Institutes of Health; Water; West Virginia; Work; Xenobiotics; base; brain tissue; cerebrovascular; cohort; disability; environmental chemical; evidence base; health economics; hypercholesterolemia; immune function; innovation; insight; man; member; modifiable risk; mortality; neurotoxicity; novel; novel strategies; perfluorooctane sulfonate; pollutant; prevent; programs

Chronic diseases are an enormous public health and economic burden, and new and growing lines of scientific evidence support a causal role for xenobiotic environmental chemicals (XECs) in the development and progression of chronic diseases, including cardio- and cerebrovascular disease (stroke). Several classes of XECs, including persistent organic pollutants and heavy metals, have been identified as increasing stroke risk, and there is emerging evidence that another class of XECs, perfluoralkyi chemicals (PFCs), may also influence stroke risk. However, there remains a knowledge gap in understanding how different PFCs may affect stroke risk and stroke outcome or how these health effects may be mediated through other conditions that causally affect stroke risk and severity. The three aims of this project are to: 1) Determine the association between PFCs and the incidence of stroke; 2) Determine the association between PFCs and stroke mortality and morbidity; and 3) Describe the natural Indirect effect of PFCs on stroke incidence and mortality and morbidity, as mediated through hypercholesterolemia and hypertension, and thyroid and immune function. This project will be conducted as an ancillary study within the REGARDS Study, an NIHfunded cohort study with an established enrollment of >30,000 people. The contribution of the work proposed here will be a systematic evaluation of the effect of multiple PFC compounds on stroke risk and stroke outcome in a diverse cohort, with a wide range of PFC exposure. The research proposed here is innovative because: 1) multiple PFC compounds will be evaluated; 2) a range PFC-related health effects and outcomes beyond mortality will be determined; 3) natural, indirect PFC-related health effects and outcomes will be determined; and 4) the present study will build upon a well-established study and so will efficiently address the study aims. It is anticipated that the results from the research proposed here will substantially advance the understanding of how PFCs affect cerebrovascular health and so will be an important progression in a continuum of research that is expected to meaningfully inform the development of public health strategies and recommendations regarding safe levels of exposure to PFCs.

慢性疾病是一种巨大的公共卫生和经济负担，新的和不断增长 科学证据支持异种生物环境化学物质（XEC）在开发中的因果作用 慢性疾病的进展，包括心脏和脑血管疾病（中风）。几个课程 XEC的XEC，包括持续的有机污染物和重金属，已被确定为增加中风 风险，并且有新兴的证据表明，另一类XEC，Pertluoralkyi化学物质（PFC）也可能 影响中风风险。但是，了解不同的PFC如何可能如何 影响中风风险和中风结果或如何通过其他条件介导这些健康效应 这会影响中风的风险和严重程度。该项目的三个目标是：1）确定 PFCS与中风发生率之间的关联； 2）确定PFC和 中风死亡率和发病率； 3）描述PFC对中风发生率和 通过高胆固醇血症和高血压介导的死亡率和发病率，甲状腺和 免疫功能。该项目将作为一项辅助研究中的辅助研究进行。 队列研究既有30,000人。提出的工作的贡献 这将是对多种PFC化合物对中风风险和中风的影响的系统评估 在各种队列中的结果，PFC暴露范围很广。这里提出的研究是创新的 因为：1）将评估多种PFC化合物； 2）范围与PFC相关的健康效应和结果 将确定死亡之外； 3）自然，间接与PFC相关的健康效应和结果将是 决定; 4）本研究将基于一项良好的研究，因此将有效地解决 该研究的目的。预计此处提出的研究的结果将大大提高 对PFC如何影响脑血管健康的理解，因此将是一个重要的进展 有意义地为制定公共卫生战略的制定的研究连续研究 以及有关安全接触PFC的建议。