Associations between Non-8-Carbon-Chain Perfuoroalkyl Acids and Serum Lipid, Live

非 8 碳链全氟烷基酸与活血清脂质之间的关联

基本信息

批准号：
8115125
负责人：
Stephanie J Frisbee
金额：
$ 18.13万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8115125
关键词：
Abbreviations Accounting Acids Alanine Transaminase Alkaline Phosphatase Alkanesulfonates Ammonium Animals Aspartate Transaminase Bilirubin Blood Urea Nitrogen Blood specimen C10 Carbon Chemicals Child Clinical Clinical Data Cohort Studies Communities Creatinine Data Diagnostic European Union Funding Gamma-glutamyl transferase HDL-triglyceride Half-Life Health High Density Lipoprotein Cholesterol Human LDL Cholesterol Lipoproteins Lactate Dehydrogenase Learning Length Life Lipids Liver Low-Density Lipoproteins Manufacturer Name Measures Mission Names Ohio Outcome Participant Peripheral Physiology Plasticizers Process Reader Regulation Renal function Research Rivers Safety Sampling Serum United States Uric Acid Washington Water Supply Wetting Agents Work World War II base carcinogenesis cohort court drinking water human population study indexing liver function man manufacturing process perfluorodecanoic acid perfluorohexane perfluorooctane sulfonate programs public drinking public health relevance total measurement Bilirubin

项目摘要

DESCRIPTION (provided by applicant): Perfluoroalkyl acids (PFAAs) are a class of man-made compounds developed after World War II for use as plasticizers, wetting agents, and as emulsifiers during industrial manufacturing processes. Two of the most common PFAAs are the 8-carbon chain chemicals perfluorooctanoic acid (PFOA or C8) and perfluorooctane sulfonate (PFOS or C8 sulfonate [C8S]). Recent, growing concern about possible health effects of PFAAs is the result of evidence that: PFAAs have a long half-life and environmental persistence; animal studies suggesting that PFAAs have deleterious effects, including carcinogenesis, and other disruptions to normal physiology; evidence of their widespread presence in human sera; and human population studies that have provided early evidence for potential exposure- related health effects. In the United States, the EPA- led PFOA Stewardship Program aims to eliminate PFOA from all emissions and products by 2015. In the European Union, the use of PFOS and derivatives was stopped in 2000 and banned in 2008, though PFOA use remains largely unregulated. As a result of this regulation, industrial manufacturers and users of PFOA or PFOS have needed to develop alternate chemicals and processes, and non-8-carbon chain PFAAs have emerged as replacement chemicals. However, almost no publically available scientific evidence exists regarding the human or environmental safety of these chemicals. The primary objective of this proposal is to determine the associations between non-8-carbon perfluoroalkyl acids (PFAAs) and serum parameters of lipid, liver, and kidney function in children. We are requesting funding to perform secondary analysis on data collected as part of the C8 Health Project, a community cohort study with 69,030 participants including more than 12,000 children. For the convenience of readers of this application, the following table summarizes the key abbreviations used throughout this application: Perfluoroalkyl Acids (PFAA) Abbreviation Full Name Carbon Length PFHxA Perfluorohexanoic acid C6 PFHS Ammonium perfluorohexane sulfonate C6S/C6 Sulfonate PFHpA Perfluoroheptanoic acid C7 PFOA Perfluorooctanoic acid C8 PFOS Perfluorooctane sulfonate acid C8S/C8 Sulfonate PFNA Perfluorononanoic acid C9 PFDA Perfluorodecanoic acid C10 Clinical Health Parameters Abbreviation Full Name LDL Cholesterol Low-density lipoprotein cholesterol HDL Cholesterol High-density lipoprotein cholesterol AlkPhos Alkaline Phosphatase ALT Alanine aminotransferase AST Aspartate aminotransferase BiliDirect Direct Bilirubin BiliTotal Total Bilirubin GGT Gamma glutamyltransferase LDH Lactate dehydrogenase BUN Blood urea nitrogen PUBLIC HEALTH RELEVANCE: NARRATIVE The primary objective of this proposal is to determine the associations between non-8-carbon perfluoroalkyl acids (PFAAs) and serum parameters of lipid, liver, and kidney function in children. We are requesting funding to perform secondary analysis on data collected as part of the C8 Health Project, a community cohort study with 69,030 participants, including more than 12,000 children, created pursuant to the pre-trial settlement of a class action lawsuit filed after PFOA contamination of drinking water supplies along the mid-Ohio River valley.

描述（由申请人提供）：全氟烷基酸（PFAAS）是第二次世界大战后开发的一类人造化合物，可用作增塑剂，润湿剂和工业制造过程中的乳化剂。最常见的两个PFAA是8-碳链化学物质全氟辛酸（PFOA或C8）和全氟辛烷磺酸盐（PFOS或C8磺酸盐[C8S]）。最近，人们对PFAA的健康影响的日益关注是证据：PFAA具有长期生活和环境持久性的证据；动物研究表明，PFAA具有有害作用，包括致癌作用和其他对正常生理学的干扰。他们在人类血清中广泛存在的证据；和人口研究提供了早期证据证明潜在的暴露与健康相关的影响。在美国，EPA-LED PFOA管理计划旨在到2015年消除所有排放和产品中的PFOA。在欧盟中，在2000年停止使用PFO和衍生产品，并于2008年被禁止，尽管PFOA仍然在很大程度上不受监管。由于该法规，PFOA或PFO的工业制造商和用户需要开发替代化学品和过程，而非8-碳链PFAA已成为替代化学品。但是，几乎没有关于这些化学物质的人类或环境安全的公开可用的科学证据。该建议的主要目的是确定儿童脂质，肝脏和肾脏功能的非8-碳全氟烷基酸（PFAA）与血清参数之间的关联。我们要求资助作为C8 Health Project的一部分收集的数据进行二级分析，C8 Health Project是一项社区人群研究，其中69,030名参与者在内，包括12,000多名儿童。 For the convenience of readers of this application, the following table summarizes the key abbreviations used throughout this application: Perfluoroalkyl Acids (PFAA) Abbreviation Full Name Carbon Length PFHxA Perfluorohexanoic acid C6 PFHS Ammonium perfluorohexane sulfonate C6S/C6 Sulfonate PFHpA Perfluoroheptanoic acid C7 PFOA Perfluorooctanoic acid C8 PFOS PLUOROOCTANE磺酸盐酸C8S/C8磺酸盐PFNA PFNA PLUORONONANOIC ACIC C9 PFDA PFDA PLUORODECANOIC AIDIC C10临床健康参数缩减全名LDL ldl cholesterol cholesterol cholesterol plySterin胆固醇Ine氨基转移酶Ast atpartate氨基转移酶双向直接胆红素双向双向双向双向总胆红素GGT GGT GAMMA谷氨酸转移酶LDH乳酸脱氢酶BUN血液尿素氮公共卫生相关性：叙述该提案的主要目的是确定儿童中脂质，肝脏和肾功能的非8-碳全氟烷基酸（PFAA）与血清参数之间的关联。我们要求资助作为C8 Health Project收集的数据进行次要分析，该项目是一项社区队列研究，该研究根据PFOA CONCONINAINTE后提起的集体诉讼诉讼，对69,030名参与者（包括12,000名儿童），包括12,000多名儿童，包括12,000多名儿童。俄亥俄河中部河谷的饮用水供应。