The Neurobiology of Sour Taste

酸味的神经生物学

基本信息

批准号：
8685756
负责人：
Thomas E Finger
金额：
$ 32.94万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8685756
关键词：
Acids Apical Area Axon Behavioral Brain Stem Cell Nucleus Cells Chemicals Code Complex Descriptor Detection Development Dictionary Discrimination Disease Elements Esthesia FOS gene Face Fiber Fingers GTP-Binding Proteins Genetic Glossopharyngeal nerve structure Intake Juice Knock-out Label Lead Mediating Medicine Modality Mus Nature Nerve Nerve Fibers Nervous system structure Neurobiology Neurons Nociceptors Oral Oral cavity Oropharyngeal P2X-receptor Perception Pharmaceutical Preparations Pharmacologic Substance Physiological Poison Population Protons Purinoceptor Reflex action Reflux Residual state Rodent Model Role Salivary Salts Sensory Sodium Solutions Specificity Stomach Structure of superior laryngeal nerve Structure of trigeminal nerve spinal tract nucleus Synapses System Taste Buds Taste Perception Testing Toxin Transgenic Mice Trigeminal System Trigeminal nerve structure Type I Epithelial Receptor Cell Type II Epithelial Receptor Cell Type III Epithelial Receptor Cell Work cellular transduction chorda tympani compliance behavior design ganglion cell glossopharyngeal hedonic public health relevance receptor relating to nervous system research study respiratory response sensor tool transmission process

项目摘要

DESCRIPTION (provided by applicant): The presence of acidic substances in the mouth evokes a sensation of sour taste. But oropharyngeal acidification is not only attributable to ingested substances, but may be produced by gastric reflux which evokes strong respiratory and salivary reflexes as well as a sensation of disgust. Acidic substances in the oral cavity not only trigger the taste system but also activate pH-sensitive general mucosal nerve fibers. Previous studies have identified the subset of taste cells necessary for sour transduction, but how these cells transmit the information to the gustatory nerves and thence the brainstem gustatory relay nuclei remains unclear. Acid-responsive mucosal nerve fibers also transmit information about intraoral pH and end within the brainstem in a partially overlapping fashion with the sour taste fibers. Experiments in this proposal utilize behavioral, pharmacological, anatomical and physiological means to examine to what degree the sour taste and non- taste systems contribute to the detection and avoidance of acids. The experiments rely on unique knockout rodent models to dissociate the functions and roles of the two intraoral acid-responsive systems. We will use both pharmacological and genetic tools to study what areas of the brainstem are activated by stimulation of one system in the absence of the other.

描述（由申请人提供）：口中存在酸性物质会引起酸味的感觉。但是口咽酸化不仅归因于摄入的物质，而且可能是由胃反流产生的，胃反流引起了强烈的呼吸和唾液反射以及厌恶的感觉。口腔中的酸性物质不仅触发味觉系统，还激活pH敏感的一般粘膜神经纤维。先前的研究已经确定了酸转导所必需的味觉细胞的子集，但是这些细胞如何将信息传输到味觉神经，然后脑干味道继电器核仍然不清楚。酸反应性粘膜神经纤维还以酸味纤维的部分重叠的方式传输有关口腔内pH的信息，并在脑干内结束。该提案中的实验利用行为，药理，解剖学和生理手段来检查酸味和非味觉系统在多大程度上有助于检测和避免酸的酸。这些实验依靠独特的敲除啮齿动物模型来解离两个口内酸反应系统的功能和作用。我们将同时使用药理学和遗传工具来研究在没有另一个系统的情况下，通过刺激一个系统激活脑干的哪个区域。