FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South Florida

FIU-ABCD：南佛罗里达州拉丁裔青年成瘾的途径和机制

• 批准号: 9054512
• 负责人: Raul Gonzalez
• 金额: $ 106.31万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9054512
• 关键词: 10 year old; Academic achievement; Accounting; Acculturation; Adolescence; Adolescent; Affect; Age; Alcohol or Other Drugs use; Area; Attention deficit hyperactivity disorder; Behavior; Brain; Cereals; Childhood; Cities; Cognition; Communities; Conduct Disorder; Country; Data; Data Coordinating Center; Development; Diagnosis; Disruptive Behavior Disorder; Enrollment; Environmental Risk Factor; Exhibits; Family; Florida; Genetic; Goals; Health; Hispanic-serving Institution; Hispanics; Immigrant; Individual; International; Knowledge; Latin America; Latino; Longitudinal Studies; Measurement; Measures; Mental Health; Minority Groups; Mission; Motivation; Neurobiology; Neurocognition; Neurocognitive; Oppositional Defiant Disorder; Participant; Pathway interactions; Pattern; Pharmaceutical Preparations; Policies; Population; Positioning Attribute; Prevention; Psychological Factors; Psychopathology; Psychosocial Factor; Recruitment Activity; Risk; Risk Factors; Role; Sampling; Sampling Studies; Science; Severities; Site; Specific qualifier value; Structure; Substance Addiction; Substance Use Disorder; Symptoms; Time; United States; Universities; Youth; addiction; cognitive development; critical period; emotion regulation; ethnic minority population; executive function; experience; improved; neurobiological mechanism; neurodevelopment; neuroimaging; neuropsychological; offspring; physical conditioning; prospective; psychosocial; psychosocial development; public health relevance; racial and ethnic; resilience; reward processing; young adult

 DESCRIPTION (provided by applicant): Despite significant recent breakthroughs in our understanding of the neurobiological mechanisms involved in substance use (SU) and addiction, progress remains modest toward integrative knowledge on how psychosocial, neurocognitive, and neurobiological risk factors jointly influence SU initiation, escalation, and addiction, and how they are affected in return. The complexity of SU behaviors, their emergence during critical periods of neurodevelopment, and their strong linkages with physical and mental health, demands a comprehensive large- scale, prospective longitudinal study that begins with youth prior to initiation of SU and that incorporates genetic, psychosocial, cultural, neuropsychological, and neuroimaging measures. The aims of this study align with those of the Adolescent Brain Cognitive Development (ABCD) Study Consortium as set forth in RFA-DA-15-015. These are to: (1) Establish how diverse patterns of SU use impact the structure and function of the developing brain; (2) Identify the impact of SU use on health, psychosocial development, neurocognition, academic achievement, motivation, and emotional regulation; (3) Understand how SU and addiction affect the onset, course, and severity of psychopathology, and vice versa; (4) Identify factors that influence trajectories of SU and its consequences; and (5) Establish how use of one substance contributes to use of other substances. As the largest ethnic minority group in the US, Latinos merit a significant position in the enrollment plan for th ABCD study. The Florida International University (FIU) ABCD site will uniquely contribute to achieving these aims and enhance their impact and significance through enrollment of 900 multi-ethnic Latino youth from South Florida who will be 9 to 10 years old at baseline and substance naïve. The vast majority of our sample will be normally developing, but 30% will have a diagnosis of a disruptive behavior disorder (DBD; i.e., ADHD, Conduct Disorder, or Oppositional Defiant Disorder) to increase likelihood of observing initiation and escalation of SU in the sample and to better understand mechanisms accounting for the strong linkages between DBDs and SU trajectories. Furthermore, multidimensional assessment of cultural factors at the individual, intra-familial, and community level in this unique sample, will allow for characterization of how dynamic relationships between cultural factors (e.g., acculturation and biculturalism) influence SU initiation, escalation, and addiction, as well as underlying mechanisms. Participants will complete six assessment waves during the first 5 years of the study, which includes detailed assessments of SU and various psychosocial, cultural, neuropsychological, and neuroimaging measures. In conjunction with the ABCD Coordinating Center, Data Center, and selected sites, this study will reveal how psychosocial (including cultural), neurocognitive, and neurobiological factors dynamically interact to influence SU trajectories during development from childhood through adolescence and into young adulthood. The findings of the ABCD Study will further NIDA's mission to apply cutting-edge science to issues of SU and addiction in order to inform policy and improve prevention and treatment.

 描述（由适用提供）：尽管我们对涉及的物质使用（SU）和成瘾的神经生物学机制的了解最近取得了重大突破，但进步仍然是关于对心理社会，神经认知和神经生物学风险因素如何共同影响SU SU Initiative，升级，升级，成瘾以及如何影响的综合知识的综合知识。 SU行为的复杂性，它们在神经发育的关键时期的出现以及它们与身体和心理健康的紧密联系需要一项全面的大规模，前瞻性的纵向研究，该研究始于SU的青年，并结合了遗传学，心理社会，文化，文化，神经心理学和神经形象。这项研究的目的与RFA-DA-15-015中规定的青少年脑认知发展（ABCD）研究联盟相吻合。这些是：（1）建立SU使用的潜水模式如何影响发育中的大脑的结构和功能； （2）确定使用SU对健康，社会心理发展，神经认知，学术成就，动机和情绪调节的影响； （3）了解SU和成瘾如何影响心理病理学的发作，过程和严重性，反之亦然； （4）确定影响SU轨迹及其后果的因素； （5）确定一种物质的使用如何有助于使用其他物质。作为美国最大的少数民族群体，拉丁裔在ABCD研究的入学计划中值得一个重要的立场。佛罗里达国际大学（FIU）ABCD网站将通过入学，从而在基线和幼稚的物质时招收9到9至10岁的900名来自南佛罗里达州的多民族拉丁裔青年，从而为实现这些目标做出独特的贡献，并增强其影响力和意义。我们的绝大多数样本通常都会正常开发，但是30％的样本将诊断出颠覆性行为障碍（DBD；即ADHD，行为障碍或可选的反抗障碍），以增加样品中SU的可能性和SU升级的可能性，并更好地了解DBD和Supuredies of DBD和Supurediores的强烈联系的机制。此外，在这个独特的样本中对个人，家庭内和社区水平的文化因素的多维评估将允许表征文化因素之间的动态关系（例如，适应性和双文化主义）如何影响SU的主动性，升级和加法，以及加法以及基本机制。参与者将在研究的前5年完成六个评估波，其中包括对SU和各种社会心理，文化，神经心理学和神经成像措施的详细评估。本研究与ABCD协调中心，数据中心和选定地点结合使用，将揭示心理心理（包括文化），神经认知和神经生物学因素如何动态相互作用，从而影响从儿童到青少年到青少年到年轻成年的发展过程中的SU轨迹。 ABCD研究的结果将进一步将NIDA的使命应用于SU和成瘾问题，以便为政策和改进的预防和治疗提供信息。