Ossicle vibration measurements in conductive hearing loss

传导性听力损失中的小骨振动测量

• 批准号: 8833269
• 负责人: STEVEN L. JACQUES
• 金额: $ 41.45万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8833269
• 关键词: Address; Affect; Air; Algorithms; American; Audiometry; Blood flow; Clinical; Clinical Research; Clinical assessments; Computer Simulation; Computer software; Conductive hearing loss; Data; Devices; Diagnosis; Diagnostic; Disease; Ear; Etiology; Excision; Experimental Models; Gender; Goals; Hand; Health; Hearing; Human; Image; Incus; Interferometry; Left; Life; Location; Malleus; Measurement; Measures; Methods; Modeling; Morphology; Movement; Noise; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Ossicular Replacement Prosthesis; Otologic Surgical Procedures; Otoscopes; Patients; Pilot Projects; Procedures; Process; Property; Recruitment Activity; Research; Residual state; Science; Series; Signal Transduction; Site; Specimen; Speed; Stapes; Structure; Surgical Disarticulation; Surgical Management; System; Techniques; Technology; Temporal bone structure; Testing; Tissues; Translating; Tympanic membrane; age effect; base; bone; clinical application; design; effective therapy; experience; hearing impairment; human subject; imaging modality; improved; innovation; innovative technologies; instrument; interdisciplinary collaboration; light scattering; middle ear; nanometer; novel; performance tests; pressure; prototype; reconstruction; research study; response; sample fixation; sound; tissue phantom; tool; vibration

DESCRIPTION (provided by applicant): The proposal develops a hand-held otoscope that uses optical coherence tomography (OCT) to image the tympanic membrane and ossicles behind an intact tympanic membrane. The system is based on spectral Fourier-domain OCT and can measure vibrations of the ossicles (malleus, incus, stapes) of the middle ear on the scale of nm to ¿m amplitude. In Aim 1 we construct and develop a protype of the otoscope testing the performance of the hardware and middle ear analysis software using phantom objects with known vibration. In Aim 2 we use the prototype otoscope to study human temporal bone specimens to investigate ossicular chain 'disorders' by experimental ossicle fixations and disarticulations. Aim 3 is a pilot clinical use in recruited human subjects with normal or pathological middle ear function as assessed by conventional methods. This new otoscope will greatly improve the non-invasive diagnosis of conductive hearing loss. Current practice relies on either indirect assessment of ossicle movement by measuring compliance of the tympanic membrane to sound or pressure, or direct examination after surgically cutting the tympanic membrane to gain access to the ossicles. The OCT otoscope can directly image and measure vibrations noninvasively, without cutting the tympanic membrane. The project will yield an innovative, non-invasive diagnostic instrument capable of localizing the site of conductive hearing loss behind an intact tympanic membrane. The OCT otoscope will facilitate a better understanding of sound conduction in normal, diseased and reconstructed middle ears, allowing clinicians to make more precise pre-surgical diagnosis, to analyze more informatively post-surgical results, and ultimately to develop more effective treatments for patients with conductive hearing loss.

描述（由申请人提供）：该提案开发了一种手持式耳镜，使用光学相干断层扫描 (OCT) 对完整鼓膜后面的鼓膜和小骨进行成像。该系统基于光谱傅里叶域 OCT，可以测量振动。中耳小骨（锤骨、砧骨、镫骨）的尺寸，从 nm 到 ¿在目标 1 中，我们构建并开发了一个耳镜原型，使用具有已知振动的模型对象来测试硬件和中耳分析软件的性能。在目标 2 中，我们使用原型耳镜来研究人类颞骨样本以研究听小骨。目的 3 是一项针对通过传统方法评估的正常或病理性中耳功能的人类受试者的临床试验。耳镜将极大地改善传导性听力损失的无创诊断，目前的做法是通过测量鼓膜对声音或压力的顺应性来间接评估听小骨的运动，或者在手术切割鼓膜以进入耳道后进行直接检查。 OCT 耳镜可以无创地直接成像和测量振动，而无需切割鼓膜，该项目将产生一种能够定位小骨部位的创新型无创诊断仪器。 OCT 耳镜将有助于更好地了解正常、患病和重建中耳的声音传导，从而做出更精确的术前诊断，并最终分析更多信息。为传导性听力损失患者开发更有效的治疗方法。