BIOMEDICAL OPTICS FOR MEDICAL RESEARCH AND CLINICAL CARE

用于医学研究和临床护理的生物医学光学

基本信息

批准号：
6751910
负责人：
STEVEN L. JACQUES
金额：
$ 38.42万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-06-06 至 2005-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6751910
关键词：
bioengineering /biomedical engineering bioimaging /biomedical imaging biomaterial development /preparation biomedical equipment development biomedical facility clinical research diagnosis design /evaluation human subject implant laboratory mouse laboratory rat medical implant science neoplasm /cancer diagnosis optics tissue engineering

项目摘要

Biomedical Optics is a field using light to interrogate tissues for diagnostic purposes and to treat disease and assist surgery, with applications in both biomedical research and clinical care. Oregon has a network of bioengineering laboratories specializing in biomedical optics and two medical centers with clinical activities using biomedical optics and medical lasers. This proposal would establish a Biomedical Optics Laboratory on the campus of the Oregon Health Sciences University (OHSU) as a core research facility to support the interface of new optical technologies from the bioengineering network with projects in the medical research and clinical activities at OHSU. The bioengineering network includes the Oregon Medical Laser Center at Providence St. Vincent Medical Center (OMLC), the Oregon Graduate Institute of Science and Technology (OGI), the Department of Biomaterials and Biomechanics (OHSU) and the University of Oregon Center for Optics (UO). The proposal would provide funding for the bioengineering network to initiate new projects for translation into the medical center. The design- directed projects of the bioengineering network are organized around hypothesis-driven projects of biomedical investigators and clinicians at the medical centers. The initial projects fall under two broad themes: (1) tissue engineering and biomaterials development with initial emphasis on bone regeneration and biomaterial implants, and (2) cancer detection and treatment with initial emphasis on optical imaging of dysplasia and superficial cancer, optical fiber devices for dosimetry and treatment evaluation during light-activated chemotherapy (photodynamic therapy or PDT), and PDT as a tool in basic medical research. Management and outreach activities of the program include an annual review by an external advisory board, a symposium at the annual Oregon Academy of Sciences meeting, and a website with extensive database and educational materials. The research program complements a Biomedical Optics curriculum.

生物医学光学是一个利用光来询问组织以进行诊断、治疗疾病和辅助手术的领域，可应用于生物医学研究和临床护理。俄勒冈州拥有专门从事生物医学光学的生物工程实验室网络和两个利用生物医学光学和医用激光开展临床活动的医疗中心。该提案将在俄勒冈健康科学大学 (OHSU) 校园内建立一个生物医学光学实验室，作为核心研究设施，以支持生物工程网络中的新光学技术与 OHSU 医学研究和临床活动项目的接口。生物工程网络包括俄勒冈州普罗维登斯圣文森特医疗中心 (OMLC) 医疗激光中心、俄勒冈州科学技术研究生院 (OGI)、生物材料和生物力学系 (OHSU) 以及俄勒冈大学光学中心 ( UO）。该提案将为生物工程网络提供资金，以启动新项目并转化为医疗中心。生物工程网络的设计导向项目是围绕医疗中心生物医学研究人员和临床医生的假设驱动项目组织的。最初的项目分为两大主题：(1) 组织工程和生物材料开发，最初侧重于骨再生和生物材料植入；(2) 癌症检测和治疗，最初侧重于不典型增生和浅表性癌症的光学成像、光纤设备用于光激活化疗（光动力疗法或 PDT）期间的剂量测定和治疗评估，以及 PDT 作为基础医学研究的工具。该计划的管理和外展活动包括外部顾问委员会的年度审查、俄勒冈科学院年度会议的研讨会以及包含广泛数据库和教育材料的网站。该研究项目是对生物医学光学课程的补充。