Computational and Technical Support for Clinical Trials and Physics Research for

临床试验和物理研究的计算和​​技术支持

• 批准号: 8940369
• 负责人: Hanne M Kooy
• 金额: $ 10.12万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8940369
• 关键词: Adverse effects; Cancer Patient; Caring; Charge; Clinical; Clinical Trials; Clinical effectiveness; Clinical trial protocol document; Data Base Management; Dependency; Development; Dose; Enrollment; Funding; Grant; Instruction; Intensity modulated proton therapy; Intensity-Modulated Radiotherapy; Licensing; Malignant Neoplasms; Mission; Modeling; Normal tissue morphology; Participant; Patients; Performance; Photons; Physics; Protocols documentation; Protons; Public Domains; Public Health; Radiation; Radiation therapy; Research; Resources; Safety; Services; System; Technology; Time; Treatment Protocols; Uncertainty; United States; Validation; Work; advanced system; base; cloud based; computing resources; design; dosimetry; improved; infrastructure development; particle; programs; proton beam; quality assurance; simulation; treatment planning; tumor; verification and validation

This core C provides services, developments and infrastructure to support: (1) treatment planning and delivery activities for MGH for patients enrolled on clinical trial protocols, including protocol treatments using IMRT, 3D CRT and SOBP and PBS treatment fields; (2) quality, dosimetry and technical validation of protocol design and delivery, including quantifying workflow efficiencies and analysis of workflow safety modes; (3) advancement of optimization technologies in support of PBS treatment planning in the presence of time-dependencies and physical uncertainties; (5) a framework for development and deployment of treatment planning and verification resources in support of the above aims; and (5) Cloud-based access for other POI participating centers to deployed resources. This core supports the mission of the NCI to improve the treatment and continuing care of cancer patients.

该核心C提供服务，开发和基础设施以支持：（1）治疗计划和 为参加临床试验方案的患者的MGH提供活动，包括使用方案治疗 IMRT，3D CRT和SOBP和PBS治疗领域； （2）质量，剂量和技术验证 协议设计和交付，包括量化工作流程效率和工作流安全性分析 模式； （3）优化技术的发展，以支持PBS治疗计划。 时间依赖性和身体不确定性； （5）开发和部署的框架 治疗计划和验证资源以支持上述目的； （5）基于云的访问 其他POI参与中心部署资源。该核心支持NCI的使命改进 癌症患者的治疗和持续护理。