Clinical and Computational Support

临床和计算支持

• 批准号: 8142779
• 负责人: Hanne M Kooy
• 金额: $ 24.27万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8142779
• 关键词: Cancer Center; Clinical; Clinical Trials; Dose; Enrollment; Equipment; Evaluation; General Hospitals; Image; Immobilization; Maintenance; Massachusetts; Measurement; Methods; Nature; Non-Small-Cell Lung Carcinoma; Patients; Play; Process; Protons; Research; Research Infrastructure; Role; Services; Site; Speed; System; Techniques; Text; University of Texas M D Anderson Cancer Center; design; dosimetry; image processing; in vivo; parallel processing; quality assurance; respiratory; treatment planning; treatment site; verification and validation

The role of Core B is to provide the following services: (1) support for treatment planning, (2) quality assurance and delivery of treatments for patients enrolled in the clinical trials of Projects 1 and 2, (3) Monte Carlo computations and management of high-speed parallel processing system for all four projects, and (4) measurements in phantom for experimental verification and validation of computed dose distributions for all four projects. This core will also play a significant role in the implementation of new methods resulting from research in Projects 1 through 4. Examples include image-guided setup, respiratory-gating, new plan evaluation techniques, in vivo dosimetry, reduced margins, adaptive replanning and intensity modulated proton therapy. For Project 1 (non-small cell lung cancers) and Project 2 (other challenging sites) treatment site-specific support will be provided for 1) immobilization, imaging (including repeat imaging and 4D imaging) and treatment set up; (2) planning of PSPT and IMPT, incorporation of results of research into treatment plan design and evaluation strategies and maintenance of proton treatment planning infrastructure; (3) quality assurance of new planning and treatment techniques prior to their clinical implementation; (4) patient specific dosimetric quality assurance; (5) image-guided setup and respiratory-gating; and (6) in-vivo dosimetry. The high-speed parallel CPU cluster system will be used for Monte Carlo calculations, optimization and image processing for all four projects. Because of the differences in equipment, systems and processes between MGH and MDACC, Core B has been divided into two parts. Core B1 will support MGH activities whereas Core B2 will support the MDACC activities

核心B的作用是提供以下服务：（1）支持治疗计划，（2）质量 在项目1和2，（3）蒙特的临床试验中招收的患者的保证和提供治疗 所有四个项目的高速平行处理系统的CARLO计算和管理，以及（4） 用于实验验证和验证计算剂量分布的幻影的测量 四个项目。 该核心还将在实施因研究而导致的新方法中发挥重要作用 项目1至4。示例包括图像引导的设置，呼吸门，新计划评估 技术，体内剂量法，边缘减小，自适应重新植入和强度调节质子治疗。 对于项目1（非小细胞肺癌）和项目2（其他具有挑战性的地点）治疗特定地点 将为1）固定成像（包括重复成像和4D成像）提供支持 治疗设置； （2）PSPT和IMPT的计划，将研究结果纳入治疗计划 设计和评估策略以及质子治疗计划基础设施的维护； （3）质量 在临床实施之前确保新计划和治疗技术； （4）特定于患者 剂量保证； （5）图像引导的设置和呼吸门控； （6）体内剂量测定法。 高速并行CPU群集系统将用于蒙特卡洛计算，优化和 所有四个项目的图像处理。 由于MGH和MDACC之间的设备，系统和流程有所不同，核心B具有 被分为两个部分。核心B1将支持MGH活动，而核心B2将支持MDACC 活动