Tribocorrosion in Modular Hip Joint Junctions-A Parametric Mechanistic Study

模块化髋关节连接处的摩擦腐蚀——参数化机制研究

• 批准号: 8446887
• 负责人: Mathew Thoppil Mathew
• 金额: $ 7.65万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-07 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8446887
• 关键词: Acceleration; Address; Adult; Adverse effects; Adverse event; Affect; Alloys; Appearance; Area; Arthritis; Behavior; Characteristics; Chemicals; Corrosion; Corrosives; Coupled; Couples; Coupling; Data; Drug Formulations; Environment; Equipment Malfunction; Equipment and supply inventories; Evolution; Failure; Female; Goals; Head; Head and neck structure; Health; Hip Joint; Hip Prosthesis; Hip region structure; Implant; Influentials; Injury; Investigation; Ions; Joints; Kinetics; Lead; Left; Life; Link; Longevity; Maps; Measurement; Mechanics; Medical; Metals; Mission; Modeling; Modernization; Motion; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Operative Surgical Procedures; Outcome; Pain; Pathway interactions; Patients; Principal Investigator; Process; Public Health; Reaction; Reporting; Research; Retrieval; Role; Series; Simulate; Solutions; Staging; Surface; Surgeon; Techniques; Testing; Tissues; Total Hip Replacement; Traumatic Arthropathy; United States; Variant; aged; base; cost; cost effective; design; disability; environmental change; expectation; flexibility; male; particle; prevent; programs; stem; successful intervention; synergism

DESCRIPTION (provided by applicant): Arthritis affects 50 million U.S. adults (most of whom are aged <65 years) with costs of $128 billion annually, and continues to be the most common cause of disability in the United States. By 2030, an estimated 67 million adults (one in four) are expected to be affected by arthritis. In severe cases, total hip replacements (THR) are accepted as a cost-effective and clinically successful intervention. A well functioning THR should be one that is durable (lasting for the duration of the patient's life) and enables the suffering patient o continue a normal life with minimum side effects on the host body. Currently, the average life span of a THR is estimated at 15 years most likely followed by multiple revision surgeries, particularly in the case of younger patients. One of the major concerns for metal-based hip implants is the loosening and subsequent failure of the femoral stem at the modular junction. The modular junction has been of serious concerns because of the coupled action of mechanical micro-motions (fretting) and the contact of two metals while in a corrosive environment that causes variations in the corrosion kinetics mainly due to galvanic coupling. Numerous surface analysis reports of retrieved metal implants have demonstrated evidence of fretting-corrosion at modular junctions. Previous studies on the fretting-corrosion of modular junctions reported the detrimental role of mechanically assisted corrosion (MAC) which is an unpredictable acceleration in the corrosion rates in association with mechanical wear. Hence, the synergistic approach of tribocorrosion that links tribology and corrosion is necessary to identify the pathways of failure at modular junctions. In this investigation the fundamental mechanisms influencing the tribocorrosion behavior of Ti and CoCrMo alloy in a simulated joint environment will be conducted. This technique will address the interaction between mechanical action, electrochemical degradation, metal ions and wear debris present at the modular junction interface. The objective in this application is to clearly define the potential mechanisms enabling the early failure of hip prostheses at the modular junction. We propose the following specific aims. Aim 1: Identify potential fretting regimes and the influence of pH level and load on the corrosion tendency. Aim 2: Study the electrochemical characteristics of the metal interface and the variability of the corrosion kinetics as a function of pH and load Aim 3: Develop a tribocorrosion synergistic model for Ti and CoCrMo alloys and identify the mechanistic transitions as a function of pH and fretting regime. It is expected that after the completion of ths project the failure mechanisms related to tribocorrosion will be determined and design improvements can be proposed to provide a safer modular junction that will assist the NIAMS mission of long-term solutions for the patients at a critical stage of arthritis. PHS 398/2590 (Rev 06/09) Page Continuation Format Page

描述（由申请人提供）：关节炎影响 5000 万美国成年人（其中大多数年龄 <65 岁），每年造成 1280 亿美元的损失，并且仍然是美国最常见的残疾原因。到 2030 年，估计有 6700 万成年人（四分之一） 预计会受到关节炎的影响。在严重的情况下，全髋关节置换术（THR）被认为是一种具有成本效益且临床成功的干预措施。功能良好的 THR 应该是耐用的（在患者的一生中持续），并使受苦的患者能够继续正常的生活，同时对宿主身体的副作用最小。目前，THR 的平均寿命估计为 15 年，之后很可能需要进行多次翻修手术，特别是对于年轻患者。金属髋关节植入物的主要问题之一是模块化连接处股骨柄的松动和随后的失效。模块化接头一直受到严重关注，因为在腐蚀环境中机械微运动（微动）和两种金属接触的耦合作用主要由于电耦合而导致腐蚀动力学的变化。回收的金属植入物的大量表面分析报告已经证明了模块化连接处存在微动腐蚀的证据。先前对模块化接头微动腐蚀的研究报告了机械辅助腐蚀（MAC）的有害作用，这是与机械磨损相关的腐蚀速率不可预测的加速。因此，将摩擦学和腐蚀联系起来的摩擦腐蚀协同方法对于识别模块化连接处的失效途径是必要的。在这项研究中，我们将研究在模拟接头环境中影响 Ti 和 CoCrMo 合金摩擦腐蚀行为的基本机制。该技术将解决模块化连接界面处存在的机械作用、电化学降解、金属离子和磨损碎片之间的相互作用。本申请的目的是明确定义潜在的机制，使 髋关节假体在模块化连接处的早期失效。我们提出以下具体目标。目标 1：确定潜在的微动磨损状态以及 pH 值和负载对腐蚀倾向的影响。目标 2：研究金属界面的电化学特性以及腐蚀动力学随 pH 值和负载变化的变化 目标 3：开发 Ti 和 CoCrMo 合金的摩擦腐蚀协同模型，并确定随 pH 值和微动变化的机械转变政权。预计该项目完成后，将确定与摩擦腐蚀相关的失效机制，并提出设计改进建议，以提供更安全的模块化连接，这将有助于 NIAMS 为处于关键阶段的患者提供长期解决方案的使命。关节炎。 PHS 398/2590 (Rev 06/09) 页面延续格式页面