Progenitor Cell Biology Consortium Administrative Coordinating Center

祖细胞生物学联盟行政协调中心

• 批准号: 8842683
• 负责人: MICHAEL L TERRIN
• 金额: $ 351.74万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8842683
• 关键词: Acute myocardial infarction; Address; Ancillary Study; Award; Biology; Bone Marrow; Bone Marrow Transplantation; Cardiac; Cardiovascular Diseases; Cell Differentiation process; Cell Lineage; Cells; Cellular biology; Communication; Data; Data Analyses; Development; Faculty; Fetal Hemoglobin; Funding; Goals; Hematological Disease; Human; Learning; Left Ventricular Remodeling; Lung; Lung diseases; Medical; Medicine; National Heart, Lung, and Blood Institute; Natural regeneration; Performance; Pilot Projects; Process; Reagent; Reporting; Research; Research Personnel; Sickle Cell Anemia; Stem cells; Technology; Tissues; Translating; Transplantation; United States; Writing; data management; experience; meetings; regenerative; skills; stem; success; symposium; web site

DESCRIPTION (provided by applicant): The regeneration of human bone marrow from transplantation is now a common medical practice in the United States. Although stem cells resident in cardiac tissues and pulmonary tissues have been identified in humans, much remains to be learned about stem cell and progenitor cell biology in these tissues and in the bone marrow. A Consortium (the NHLBI Progenitor Cell Biology Consortium) could take advantage of recent developments (discoveries, technologies and reagents) to Identify and characterize progenitor cell lineages, to direct the differentiation of stem and progenitor cells and to address the challenges of transplanting those cells to translate into treatments in the regenerative biology and medicine armamentarium. An Administrative Coordinating Center (ACC) is necessary for this Consortium to achieve its goals of applying advances in stem and progenitor cell biology to advance the identity of cardiovascular, lung and blood diseases. The proposed ACC has the knowledgeable and experienced faculty and staff and a plan to provide outstanding administrative and technical support to the NHLBI Progenitor Cell Biology Consortium. The proposed ACC has a strong track record in and will organize meeting and conference calls, maintain written documents and a website, award subcontracts, oversee review and award of pilot and ancillary study funds, and process those studies, renewals and reports. The communications and professorial (instructional) strengths of the proposed ACC will enhance coordination of skills development activities. By bringing together collaborating groups of progenitor cell biology investigators and their data, organizing communications and information, and disseminating findings, the ACC will make an important contribution to the success of the NHLBI Progenitor Cell Biology Consortium.

描述（由申请人提供）： 通过移植再生人类骨髓现在在美国是一种常见的医疗实践。尽管已经在人体中鉴定出存在于心脏组织和肺组织中的干细胞，但关于这些组织和骨髓中的干细胞和祖细胞生物学仍有很多知识需要了解。联盟（NHLBI 祖细胞生物学联盟）可以利用最新的发展（发现、技术和试剂）来识别和表征祖细胞谱系，指导干细胞和祖细胞的分化，并解决将这些细胞移植到体内的挑战。转化为再生生物学和医学装备中的治疗方法。该联盟需要一个行政协调中心 (ACC)，以实现其应用干细胞和祖细胞生物学进展来推进心血管、肺和血液疾病识别的目标。拟议的 ACC 拥有知识渊博、经验丰富的教职员工，并计划为 NHLBI 祖细胞生物学联盟提供出色的行政和技术支持。拟议的 ACC 在组织会议和电话会议、维护书面文件和网站、授予分包合同、监督试点和辅助研究资金的审查和授予以及处理这些研究、更新和报告方面拥有良好的记录。拟议的 ACC 的沟通和教授（教学）优势将加强技能发展活动的协调。通过汇集祖细胞生物学研究人员的合作小组及其数据、组织通信和信息以及传播研究结果，ACC 将为 NHLBI 祖细胞生物学联盟的成功做出重要贡献。

项目成果

Contact hypersensitivity to oxazolone provokes vulvar mechanical hyperalgesia in mice.

对恶唑酮的接触性过敏会引起小鼠外阴机械性痛觉过敏。

• DOI: 10.1371/journal.pone.0078673
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Martinov,Tijana;Glenn-Finer,Rose;Burley,Sarah;Tonc,Elena;Balsells,Evelyn;Ashbaugh,Alyssa;Swanson,Linnea;Daughters,RandyS;Chatterjea,Devavani
• 通讯作者: Chatterjea,Devavani

Modulating the vascular response to limb ischemia: angiogenic and cell therapies.

• DOI: 10.1161/circresaha.115.303565
• 发表时间: 2015-04-24
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Cooke JP;Losordo DW
• 通讯作者: Losordo DW

Collagen-based engineered heart muscle.

• DOI: 10.1007/978-1-4939-1047-2_15
• 发表时间: 2014-01-01
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Tiburcy, Malte;Meyer, Tim;Zimmermann, Wolfram-Hubertus
• 通讯作者: Zimmermann, Wolfram-Hubertus

Coupling isotachophoresis with affinity chromatography for rapid and selective purification with high column utilization, part 1: theory.

将等速电泳与亲和层析结合，实现高柱利用率的快速选择性纯化，第 1 部分：理论。

• DOI: 10.1021/ac5011052
• 发表时间: 2014
• 期刊: Analytical chemistry
• 影响因子: 7.4
• 作者: Shkolnikov,Viktor;Santiago,JuanG
• 通讯作者: Santiago,JuanG

Biomechanical regulation of in vitro cardiogenesis for tissue-engineered heart repair.

• DOI: 10.1186/scrt348
• 发表时间: 2013
• 期刊: Stem cell research & therapy
• 影响因子: 7.5
• 作者: Zimmermann WH