Administrative Core

行政核心

• 批准号: 9114280
• 负责人: Marcelo Fernandez-Vina
• 金额: $ 32.67万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9114280
• 关键词: Administrative Coordination; Alleles; Budgets; Collaborations; Communication; Complex; Coordination and Collaboration; Disease; Europe; Feedback; Genes; Genetic Polymorphism; Goals; Grant; Histocompatibility; Immunogenetics; Investments; Japan; Laboratories; Leadership; Multiple Sclerosis; Myasthenia Gravis; National Institute of Neurological Disorders and Stroke; Neurology; Neuromyelitis Optica; Office of Administrative Management; Outcome; Parkinson Disease; Performance; Preparation; Principal Investigator; Progress Reports; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Risk; Schedule; Schizophrenia; Signal Transduction; Site; Students; Supervision; Time; Variant; authority; data management; disorder risk; genotyping technology; innovation; meetings; multidisciplinary; nervous system disorder; programs; promoter; repository; screening; success; symposium; working group

This project, submitted as a multi-center U19 application on behalf of the INDIGO (Immunogenetics of Neurological DIseases working GrOup) consortium, will identify and characterize the repertoire of HLA and KIR genes and alleles that predispose to neurological diseases (multiple sclerosis, neuromyelitis optica, myasthenia gravis, Parkinson's disease, and schizophrenia). This Project includes 2 independent, yet interactive components supported by a common administrative, data management, and bio-repository infrastructure. Project 1 proposes a comprehensive sequence variation screening in nine HLA loci and association analysis with disease risk. Project 2 will assess the distribution of KIR-associated variants, KIR copy number, and KIR promoter polymorphisms in the same diseases. This is a large and complex grant that spans multiple laboratories at different sites in the US, Europe, and Japan and requires a significant investment of coordination and administrative time by the Principal Investigators, with clear lines of communication, responsibilities, and authority. The Administrative Core will be co-located at the UCSF Department of Neurology and Stanford Histocompatibility, Immunogenetics and Disease Profiling Laboratory. In addition to centralized administration and budgetary oversight, the main goal of the Core is to promote the productive and collegial interaction of all participating investigators, fellows, students, and staff. The Administrative Core will be responsible for all aspects of the project including coordination of experimental and support activities, oversight of budgeting, supervision of cores and projects, scheduling of conference calls, meetings and other interactions, and communications with NINDS, including preparation of progress reports. The geographic proximity between Stanford and UCSF, together with the complementary expertise of the PIs and track record of collaborations warrant an effective, non-redundant partnership in the co-management of the Administrative Core and program. By coordinating and collaborating on data management, common genotyping technologies, and statistical analysis, this group will at once attain cohesive, innovative, and costeffective research.

该项目代表 INDIGO（免疫遗传学）提交的多中心 U19 申请 神经疾病工作组）联盟将鉴定和描述 HLA 和 易患神经系统疾病（多发性硬化症、视神经脊髓炎、 重症肌无力、帕金森病和精神分裂症）。该项目包括 2 个独立的，但 由公共管理、数据管理和生物存储库支持的交互式组件 基础设施。项目 1 提出对 9 个 HLA 位点进行全面的序列变异筛选， 与疾病风险的关联分析。项目2将评估KIR相关变异的分布，KIR 相同疾病中的拷贝数和 KIR 启动子多态性。这是一笔数额巨大且复杂的赠款 跨越美国、欧洲和日本不同地点的多个实验室，需要大量 首席研究员投入的协调和管理时间，有明确的界限 沟通、责任和权力。 行政核心将设在加州大学旧金山分校神经病学系和斯坦福大学 组织相容性、免疫遗传学和疾病分析实验室。除了集中管理之外 和预算监督，核心的主要目标是促进所有人的富有成效和合作的互动 参与的研究人员、研究员、学生和工作人员。行政核心将负责所有 该项目的各个方面，包括协调实验和支持活动、监督预算、 监督核心和项目，安排电话会议、会议和其他互动，以及 与 NINDS 的沟通，包括准备进度报告。 斯坦福大学和加州大学旧金山分校之间的地理邻近性以及 PI 的互补专业知识 和跟踪记录保证了在共同管理中建立有效的、非冗余的伙伴关系 行政核心和计划。通过在数据管理方面的协调和协作，共同 基因分型技术和统计分析，该团队将立即实现凝聚力、创新性和成本效益 研究。