Developing Research At The Interface Of HIV And Aging

开展艾滋病毒与衰老相互作用的研究

• 批准号: 9003203
• 负责人: KEVIN P. HIGH
• 金额: $ 8.4万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9003203
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Address; Adult; Age; Aging; American; Area; Behavioral Research; Biological Markers; Biology of Aging; Body Composition; Capsicum; Cardiovascular Diseases; Cardiovascular system; Caregivers; Cessation of life; Chronic; Chronic Disease; Clinical; Communities; Comorbidity; Data; Data Collection; Databases; Development; Diabetes Mellitus; Disease; Elderly; Faculty; Family; Fracture; General Population; Geriatrics; Gerontology; Goals; HIV; HIV Infections; Health; Healthcare; Hepatitis C; Hospitalization; Hypertension; Immune; Impaired cognition; Inflammation; Institutes; Intervention; Investigation; Investments; Kidney; Kidney Failure; Link; Long-Term Effects; Malignant Neoplasms; Measures; Mentors; Methodology; Methods; Morbidity - disease rate; Musculoskeletal; National Institute of Allergy and Infectious Disease; Outcome; Outcome Assessment; Patients; Persons; Pharmaceutical Preparations; Phenotype; Pilot Projects; Population; Prevention; Process; Protocols documentation; Recording of previous events; Reporting; Research; Research Infrastructure; Resources; Risk Factors; Sexually Transmitted Diseases; Smoking; Study Subject; Syndrome; Time; Training and Education; United States National Institutes of Health; Viral; aged; aging population; antiretroviral therapy; body system; clinical phenotype; data acquisition; data sharing; disability; early onset; experience; falls; frailty; functional decline; functional disability; functional outcomes; high risk; indexing; instrument; premature; research and development; response; senescence; social; success; symposium; working group

DESCRIPTION (provided by applicant): Effective antiretroviral therapy (ART) has resulted in many people with chronic HIV surviving into middle and old age. However, even those with controlled HIV viral replication, are more likely than uninfected subjects to experience premature chronic illness, multi-morbidity and functional decline. For example, 58% of HIV- infected subjects age >= 50 years have one or more of the following: renal failure, diabetes mellitus, bone fracture, hypertension or overt cardiovascular disease vs. only 35% of HIV-uninfected controls. Further, geriatric syndromes such as frailty and falls are becoming more prevalent in HIV-infected adults. While the need for research in HIV and aging is widely recognized, challenges in methodology, data acquisition and sharing, and research workforce education/training have hampered this goal. Multi-morbidity, functional decline and disability are typically research domains of geriatrics and gerontology. The Claude D. Pepper Older Americans Independence Centers (OAlCs; aka "Pepper Centers") were established to advance research into the causes, mechanisms, prevention and treatment of functional decline with age, but lack expertise in HIV. In contrast, the Centers for AIDS Research (CFARs) have unparalleled expertise in HIV- related basic, clinical and social/behavioral research, but lack resources or expertise in aging biology, clinical phenotypes, or functional measures. This proposal leverages CFAR/OAIC expertise to create a shared research platform, enhancing and accelerating investigation at the interface of HIV and aging by: 1) Harmonizing processes for data collection across OAlCs and CFARs and providing a coordinated platform for data collection; 2) Validating key instruments/measures of function and geriatric phenotypes in HIV- infected subjects age > 50 years; 3) Supporting pilot projects at the interface of HIV and aging; 4) Identifying and mentoring junior faculty with a research focus in HIV and aging; and 5) Disseminating information and data sharing opportunities to the larger scientific community. Accomplishing these aims will efficiently amplify NIAID investment in the CFARs, NIA investment in the OAlCs, and, more importantly, address critical healthcare needs in a rapidly growing population aging with HIV.

描述（由申请人提供）：有效的抗逆转录病毒疗法（ART）已使许多慢性艾滋病毒感染者存活到中老年。然而，即使是那些艾滋病毒病毒复制受到控制的人，也比未感染者更有可能过早患慢性病、多种疾病和功能衰退。例如，58% 年龄≥ 50 岁的 HIV 感染者患有以下一种或多种疾病：肾功能衰竭、糖尿病、骨折、高血压或明显的心血管疾病，而未感染 HIV 的对照组中这一比例仅为 35%。此外，虚弱和跌倒等老年综合症在感染艾滋病毒的成年人中变得越来越普遍。虽然人们广泛认识到艾滋病毒和老龄化研究的必要性，但方法、数据获取和共享以及研究人员教育/培训方面的挑战阻碍了这一目标的实现。多重发病、功能衰退和残疾是老年病学和老年学的典型研究领域。克劳德·D·佩珀美国老年人独立中心（OAlC；又名“胡椒中心”）的成立是为了推进对随年龄增长而功能衰退的原因、机制、预防和治疗的研究，但缺乏艾滋病毒方面的专业知识。相比之下，艾滋病研究中心（CFAR）在艾滋病毒相关基础、临床和社会/行为研究方面拥有无与伦比的专业知识，但缺乏衰老生物学、临床表型或功能测量方面的资源或专业知识。该提案利用 CFAR/OAIC 的专业知识创建一个共享研究平台，通过以下方式加强和加速艾滋病毒与老龄化交叉点的调查： 1) 协调 OAlC 和 CFAR 之间的数据收集流程，并提供协调的数据收集平台； 2) 验证年龄 > 50 岁的 HIV 感染者的功能和老年表型的关键仪器/测量方法； 3) 支持艾滋病毒与老龄化交叉点的试点项目； 4) 识别和指导专注于艾滋病毒和老龄化研究的初级教师； 5) 向更广泛的科学界传播信息和数据共享机会。实现这些目标将有效地扩大 NIAID 对 CFAR 的投资、NIA 对 OAlC 的投资，更重要的是，满足快速增长的艾滋病毒老龄化人口的关键医疗保健需求。