Career Development Program

职业发展计划

基本信息

批准号：
8932167
负责人：
KEVIN M. SHANNON
金额：
$ 10.45万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8932167
关键词：
Address Area Basic Science Budgets California Cancer Biology Childhood Cities Clinical Clinical Sciences Data Development Development Plans Disadvantaged Discipline Extramural Activities Faculty Funding Goals Human Indiana Individual Institution Knowledge Lesbian Gay Bisexual Link Malignant Neoplasms Medical center Mentors Mission Mutation NF1 gene National Cancer Institute Nature North Carolina Pediatric Hospitals Pennsylvania Philadelphia Population Process Recruitment Activity Reproduction spores Research Research Personnel Research Project Grants Resources San Francisco Schedule Scientist Signal Transduction Structure Texas Textiles Therapeutic Training Translational Research Underrepresented Minority Universities Woman Work abstracting anticancer research cancer therapy career career development ethnic minority population innovation meetings member professor programs skills success transgender tumor

项目摘要

ABSTRACT – CAREER DEVELOPMENT PROGRAM The Developmental Hyperactive Ras Tumor (DHART) SPORE Career Development Program (CDP) will support faculty at the Assistant Professor level to engage in translational research focused on NF1 and cancer. The specific purpose or the CDP is to advance the careers of junior investigators who are developing innovative research projects related to the goal of implementing more effective and less toxic therapies for cancers characterized by NF1 mutations. The DHART SPORE also includes a Developmental Research Program (DRP), which has the complementary mission of funding established investigators who seek to develop new research related to NF1-related cancers and is presented in a separate section of this application. The multi-institutional nature of this SPORE leverages a large and talented pool of junior faculty from multiple disciplines. Each institution views the CDP as a vehicle for recruiting, training, and advancing young scientists working in the area of translational cancer research related to NF1, and they have committed $1.3 million to support the Developmental Programs component of the DHART SPORE (DRP and CDP). The Specific Aims of the CDP are: (1) to support new investigators as they develop innovative research programs with the goal of contributing new knowledge to the field of NF1-related cancer research while generating preliminary data that will allow them to successfully apply for independent extramural funding; (2) to provide young researchers with didactic training that will equip them with essential skills and knowledge for success as an independent investigator in the field of NF1-related cancer research; (3) to mentor young translational researchers through regularly scheduled one-on-one meetings with a designated senior faculty member and a structured Individual Career Development Plan (IDP) who will fully integrate the CDP-supported investigator into the fabric of the DHART SPORE where they have access to advice, resources, and potential collaborators; and, (4) to encourage the recruitment of ethnic minorities, those from disadvantaged backgrounds, women and lesbian/gay/bisexual/transgender (LGBT) populations into research focused on NF1-associated cancers. The DHART SPORE will link vertically and horizontally to diversity programs at all of the consortium institutions. Investigators from any of these centers can apply for CDP funds, and we will also consider proposals from researchers at other institutions. The CDP will fund a minimum of two projects per year at an annual budget of $50,000 - $75,000. Applications for CDP support (including requests for a second year of funding) will be evaluated through a competitive process with review by a Developmental Programs Steering Committee comprised on senor scientists participating in this SPORE and oversight and guidance from the External and Internal Advisory Boards.

摘要 – 职业发展计划发育性过度活跃 Ras 肿瘤 (DHART) SPORE 职业发展计划 (CDP) 将助理教授级别的教职人员支持从事 NF1 和癌症的转化研究。 CDP 的具体目的是促进正在开发的初级研究人员的职业生涯与实施更有效、毒性更低的治疗方法相关的创新研究项目以 NF1 突变为特征的癌症 DHART SPORE 还包括一项发展研究。计划（DRP），其补充使命是资助已建立的研究人员，他们寻求开发与 NF1 相关癌症相关的新研究，并在本申请的单独部分中介绍。该 SPORE 的多机构性质利用了来自多个国家的大量才华横溢的初级教师队伍每个机构都将 CDP 视为招募、培训和提升年轻科学家的工具。致力于与 NF1 相关的转化癌症研究领域，他们已投入 130 万美元支持 DHART SPORE 的发展计划部分（DRP 和 CDP）。 CDP 的目标是： (1) 支持新研究者开发创新研究项目，其目标是为 NF1 相关癌症研究领域贡献新知识，同时生成初步数据将使他们能够成功申请独立的校外资助；（2）为年轻研究人员提供教学培训将使他们具备作为独立人士取得成功所需的基本技能和知识 NF1相关癌症研究领域的研究者；(3) 通过以下方式指导年轻的转化研究人员：定期安排与指定的高级教员和结构化个人的一对一会议职业发展计划 (IDP) 将 CDP 支持的调查员完全融入到组织结构中 DHART SPORE 他们可以获得建议、资源和潜在合作者；(4) 鼓励招募少数民族、弱势群体、妇女和女同性恋/男同性恋/双性恋/跨性别者 (LGBT) 群体开始关注 NF1 相关癌症的研究。 DHART SPORE 将与所有联盟机构的多元化项目纵向和横向联系。这些中心的研究人员都可以申请 CDP 资金，我们还将考虑来自以下机构的提案： CDP 每年将资助至少两个项目，年度预算为 CDP 支持申请（包括第二年的资助请求）将是 50,000 美元 - 75,000 美元。通过竞争性流程进行评估，并由发展计划指导委员会审查由参与该 SPORE 的资深科学家组成，并受到外部和外部的监督和指导内部顾问委员会。