Developmental Research Program

发展研究计划

基本信息

批准号：
10494111
负责人：
KEVIN M. SHANNON
金额：
$ 9.39万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10494111
关键词：
Acceleration Address Advanced Malignant Neoplasm Applications Grants Area Basic Science California Cancer Center Clinical Clinical Sciences Collaborations Communities Country Data Department of Defense Development Diagnosis Discipline Disease Early treatment Evaluation Funding Funding Agency Goals Health Sciences Human Human Development Indiana Institution Malignant Neoplasms Memorial Sloan-Kettering Cancer Center Mission NF1 gene NF1 mutation National Cancer Institute Neurofibromatoses Pediatric Hospitals Pediatric Oncology Philadelphia Pilot Projects Population Sciences Predisposition Process Research Research Activity Research Personnel Research Project Grants Resources San Francisco Scientist Senior Scientist Sex Orientation Signal Transduction Syndrome Talents Techniques Texas Therapeutic Translational Research Tumor stage Underrepresented Minority Underrepresented Populations United States National Institutes of Health Universities Work anticancer research base career disability effective therapy expectation faculty support high reward high risk hyperactive Ras improved innovation minority investigator neoplasm therapy professor programs racial and ethnic recruit translational cancer research translational study tumor

项目摘要

ABSTRACT – DEVELOPMENTAL REARCH PROGRAM The DHART SPORE Developmental Research Program (DRP) will support innovative pilot projects to advance the diagnosis and treatment of early stage tumors and advanced cancers characterized by germline and somatic NF1 mutations. The DRP will accomplish this goal by supporting rigorous translational research in the areas of population science, therapeutics, and mechanisms of disease. We expect that many established investigators will utilize DRP support to launch new research endeavors and to generate preliminary data in NF1 and RASopathy-associated cancers leading to successful grant applications to the NIH, the Department of Defense NF Research Program, and other funding agencies. The ultimate goal of the DRP is to advance high level research activities related to NF1-associated tumors, which we will achieve by recruiting and supporting established investigators developing a new research theme in the field of NF1-related cancers. The translational studies supported by the DRP also have the potential to replace SPORE projects that have been completed or are not progressing satisfactorily toward achieving their objectives. This SPORE also includes a Career Enhancement Program (CEP) for young investigators, which is described in a separate section of this application. The institutions participating in the DHART SPORE renewal have committed a total of $1.65 million to support the Developmental Programs of the DHART SPORE (inclusive of the DRP and CEP). Investigators from any DHART SPORE center can apply for DRP funds. In addition, we actively solicit applications from non-SPORE investigators and institutions. The specific aims of the DRP are: (1) to fund promising projects in order to generate preliminary data for grant applications to the NIH or other federal funding agencies. The DRP emphasizes supporting the recruitment of investigators from historically disenfranchised racial, ethnic, sexual orientation and disability groups that are under-represented in health sciences, hereafter termed underrepresented minority (URM) investigators ; (2) to support the development of new techniques and resources that can be applied to advance translational research to improve the treatment of NF1-associated tumors; (3) to expand the scope of research in NF1, including funding high risk/high reward projects; and, (4) to recruit talented investigators into NF1 research as it relates to cancer, and to promote new collaborations in this field across a range of investigators and disciplines. The DRP will provide evaluation, funding, and oversight for pilot projects. Each project will receive a minimum of $50,000 with a maximum of $75,000 per year, with the potential for a single renewal. Applications for DRP support (including requests for a second year of funding) will be evaluated through a competitive process with review by a Developmental Programs Steering Committee (DPSC) comprised of senior scientists participating in this SPORE and oversight and guidance from the External and Internal Advisory Boards.

摘要——发展研究计划 DHART SPORE 发展研究计划 (DRP) 将支持创新试点项目以推进以种系和生殖细胞为特征的早期肿瘤和晚期癌症的诊断和治疗 DRP 将通过支持严格的转化研究来实现这一目标。我们期望在人口科学、治疗学和疾病机制等领域取得许多成果。研究人员将利用 DRP 支持开展新的研究工作并生成初步数据 NF1 和 RAS 病相关癌症导致成功向 NIH、该部门申请拨款国防 NF 研究计划和其他资助机构的最终目标是推进。与 NF1 相关肿瘤相关的高水平研究活动，我们将通过招募和支持已建立的研究人员在 NF1 相关癌症领域开展新的研究主题。 DRP 支持的转化研究也有可能取代 SPORE 项目该 SPORE 还包括已完成或未取得令人满意的进展的目标。针对年轻研究者的职业提升计划（CEP），在本报告的单独部分中进行了描述参与 DHART SPORE 更新的机构已承诺总共 1.65 美元。百万支持 DHART SPORE 的发展计划（包括 DRP 和 CEP）。任何 DHART SPORE 中心的研究人员都可以申请 DRP 资金。此外，我们还积极募集资金。非 SPORE 研究人员和机构的申请 DRP 的具体目标是： (1) 资助。项目，以便为向 NIH 或其他联邦机构申请拨款生成初步有希望的数据 DRP 强调支持从历史上招募调查人员。被剥夺权利的种族、族裔、性取向和残疾群体在健康领域代表性不足科学，以下称为代表性不足的少数群体（URM）研究人员；（2）支持发展可用于推进转化研究以改善治疗的新技术和资源 NF1相关肿瘤的研究；（3）扩大NF1的研究范围，包括资助高风险/高回报项目；(4) 招募有才华的研究人员参与与癌症相关的 NF1 研究，并促进新的研究 DRP 将提供评估、跨学科领域的合作。每个项目将获得最少 50,000 美元、最多 50,000 美元的资金和监督。每年 75,000 美元，可以申请一次 DRP 支持（包括请求）。资助的第二年）将通过竞争性流程进行评估，并由发展部门进行审查计划指导委员会 (DPSC) 由参与此 SPORE 的资深科学家组成外部和内部顾问委员会的监督和指导。