Developmental Research Program

发展研究计划

• 批准号: 10494111
• 负责人: KEVIN M. SHANNON
• 金额: $ 9.39万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494111
• 关键词: Acceleration; Address; Advanced Malignant Neoplasm; Applications Grants; Area; Basic Science; California; Cancer Center; Clinical; Clinical Sciences; Collaborations; Communities; Country; Data; Department of Defense; Development; Diagnosis; Discipline; Disease; Early treatment; Evaluation; Funding; Funding Agency; Goals; Health Sciences; Human; Human Development; Indiana; Institution; Malignant Neoplasms; Memorial Sloan-Kettering Cancer Center; Mission; NF1 gene; NF1 mutation; National Cancer Institute; Neurofibromatoses; Pediatric Hospitals; Pediatric Oncology; Philadelphia; Pilot Projects; Population Sciences; Predisposition; Process; Research; Research Activity; Research Personnel; Research Project Grants; Resources; San Francisco; Scientist; Senior Scientist; Sex Orientation; Signal Transduction; Syndrome; Talents; Techniques; Texas; Therapeutic; Translational Research; Tumor stage; Underrepresented Minority; Underrepresented Populations; United States National Institutes of Health; Universities; Work; anticancer research; base; career; disability; effective therapy; expectation; faculty support; high reward; high risk; hyperactive Ras; improved; innovation; minority investigator; neoplasm therapy; professor; programs; racial and ethnic; recruit; translational cancer research; translational study; tumor

ABSTRACT – DEVELOPMENTAL REARCH PROGRAM The DHART SPORE Developmental Research Program (DRP) will support innovative pilot projects to advance the diagnosis and treatment of early stage tumors and advanced cancers characterized by germline and somatic NF1 mutations. The DRP will accomplish this goal by supporting rigorous translational research in the areas of population science, therapeutics, and mechanisms of disease. We expect that many established investigators will utilize DRP support to launch new research endeavors and to generate preliminary data in NF1 and RASopathy-associated cancers leading to successful grant applications to the NIH, the Department of Defense NF Research Program, and other funding agencies. The ultimate goal of the DRP is to advance high level research activities related to NF1-associated tumors, which we will achieve by recruiting and supporting established investigators developing a new research theme in the field of NF1-related cancers. The translational studies supported by the DRP also have the potential to replace SPORE projects that have been completed or are not progressing satisfactorily toward achieving their objectives. This SPORE also includes a Career Enhancement Program (CEP) for young investigators, which is described in a separate section of this application. The institutions participating in the DHART SPORE renewal have committed a total of $1.65 million to support the Developmental Programs of the DHART SPORE (inclusive of the DRP and CEP). Investigators from any DHART SPORE center can apply for DRP funds. In addition, we actively solicit applications from non-SPORE investigators and institutions. The specific aims of the DRP are: (1) to fund promising projects in order to generate preliminary data for grant applications to the NIH or other federal funding agencies. The DRP emphasizes supporting the recruitment of investigators from historically disenfranchised racial, ethnic, sexual orientation and disability groups that are under-represented in health sciences, hereafter termed underrepresented minority (URM) investigators ; (2) to support the development of new techniques and resources that can be applied to advance translational research to improve the treatment of NF1-associated tumors; (3) to expand the scope of research in NF1, including funding high risk/high reward projects; and, (4) to recruit talented investigators into NF1 research as it relates to cancer, and to promote new collaborations in this field across a range of investigators and disciplines. The DRP will provide evaluation, funding, and oversight for pilot projects. Each project will receive a minimum of $50,000 with a maximum of $75,000 per year, with the potential for a single renewal. Applications for DRP support (including requests for a second year of funding) will be evaluated through a competitive process with review by a Developmental Programs Steering Committee (DPSC) comprised of senior scientists participating in this SPORE and oversight and guidance from the External and Internal Advisory Boards.

摘要 - 开发Rearch计划 DHART SPORE发展研究计划（DRP）将支持创新的飞行员项目以促进 以种系和特征的早期肿瘤和晚期癌症的诊断和治疗 体细胞NF1突变。 DRP将通过支持严格的翻译研究来实现这一目标 人口科学，治疗和疾病机制的领域。我们希望许多人建立 调查人员将利用DRP支持来发起新的研究努力，并在 NF1和与Rasopathy相关的癌症，导致NIH成功提供赠款，该部门 国防NF研究计划和其他资助机构的。 DRP的最终目标是进步 与NF1相关肿瘤有关的高级研究活动，我们将通过招募和 支持既定的研究人员在与NF1相关的癌症领域开发新的研究主题。这 DRP支持的翻译研究也有可能取代已经 完成或没有令人满意地实现其目标。这个孢子还包括一个 年轻调查人员的职业增强计划（CEP），在此单独描述 应用。参加DHART SPORE RENEWAL的机构总计$ 1.65 数百万以支持Dhart Spore（包括DRP和CEP）的发展计划。 任何DHART孢子中心的调查人员都可以申请DRP资金。此外，我们积极征求 非杂货调查员和机构的申请。 DRP的具体目的是：（1）资助 有希望的项目，以生成向NIH或其他联邦的授予申请的初步数据 资金机构。 DRP强调支持从历史上招募调查人员 在健康方面不足的种族，种族，性取向和残疾人群体剥夺了选举权 以下称科学的少数群体（URM）调查人员； （2）支持发展 可以应用的新技术和资源来推进转化研究以改善治疗 NF1相关的肿瘤； （3）扩大NF1研究范围，包括资金高风险/高奖励 项目； （4）要招募有才华的研究人员参与NF1研究，并促进新的 该领域的一系列研究人员和学科的合作。 DRP将提供评估， 资金和试点项目的监督。每个项目将最低$ 50,000，最高为50,000美元 每年$ 75,000，有可能进行一次续约。 DRP支持的申请（包括请求 资金的第二年）将通过竞争过程进行评估，并通过发展审查 计划指导委员会（DPSC）完成了参加此孢子的高级科学家 外部和内部咨询委员会的监督和指导。