Behavioral Interventions and Long Term Outcomes in Juvenile Fibromyalgia Syndrome

青少年纤维肌痛综合征的行为干预和长期结果

• 批准号: 8629178
• 负责人: Susmita Kashikar-Zuck
• 金额: $ 16.71万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8629178
• 关键词: 19 year old; 21 year old; 3-Dimensional; Achievement; Adherence; Adolescence; Adolescent; Adult; Aftercare; Age; Anxiety; Anxiety Disorders; Award; Behavior Therapy; Body measure procedure; Build-it; Child; Childhood; Clinical Investigator; Clinical Research; Clinical Trials; Cognitive Therapy; Collaborations; Coping Skills; DSM-IV; Data; Data Collection; Development; Diagnosis; Educational Status; Exercise; Faculty; Fatigue; Fibromyalgia; Flare; Fright; Funding; Future; Goals; Grant; Human; Impairment; Individual; Institution; Interdisciplinary Study; Intervention; Longitudinal Studies; Maintenance; Manuscripts; Measures; Medicine; Mental Depression; Mentors; Mentorship; Methods; Migraine; Modeling; Mood Disorders; Moods; Motion; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Neurology; Outcome; Pain; Pain Research; Pain intensity; Pain interference; Pain management; Pain quality; Paper; Patients; Pharmaceutical Preparations; Physical activity; Postdoctoral Fellow; Prevention; Process; Public Health; Publishing; Recording of previous events; Reporting; Research; Research Methodology; Research Personnel; Research Project Grants; Rheumatology; Science; Scientist; Self Management; Severities; Site; Social Functioning; Social support; Sports Medicine; Symptoms; Teenagers; Testing; Time; Training; Training Programs; United States National Institutes of Health; Work; Writing; base; body mechanics; career; chronic pain; cohort; control trial; coping; depressive symptoms; disability; effective intervention; follow-up; functional disability; improved; injury prevention; innovation; interest; meetings; neuromuscular; next generation; novel; patient oriented research; pilot trial; primary outcome; programs; prospective; psychologic; psychosocial; public health relevance; randomized trial; secondary outcome; skills training; success; tool; young adult

DESCRIPTION (provided by applicant): The Specific Aims of this Midcareer Investigator Award renewal application are to 1) successfully implement an ongoing prospective longitudinal study to determine long term outcomes of pediatric patients with juvenile- onset fibromyalgia (JFM), 2) to refine and test a novel intervention, i.e., combined cognitive-behavioral therapy (CBT) and physical exercise to reduce pain and impairment, and increase coping and physical activity in adolescents with JFM, and 3) continue to use the candidate's ongoing and planned clinical studies in pediatric pain to train postdoctoral fellows and junior faculty. The Candidate s a nationally recognized pediatric pain researcher with a history of >10 years of independently funded patient-oriented research focused on clinical trials of behavioral treatment for JFM and other pain conditions, longitudinal studies, and mentorship of early career researchers. In the first 3.5 years of her current K24 funding, she completed the first rigorously controlled trial demonstrating that CBT is a safe and effective intervention for reduction of disability and depression in JFM and she published 22 papers (along with her mentees) based on her JFM and pediatric pain research. The proposed Research Plan for this renewal application includes two projects: 1) an ongoing NIAMS (R01) funded longitudinal study of long-term outcomes of adolescents with JFM, and 2) an ongoing pilot trial of a novel combined CBT and exercise - FIT Teens (Fibromyalgia Integrative Training for Teens) intervention. The innovation of this new program is that it builds on the candidate's established CBT program and seamlessly integrates an exercise component modified from sports-medicine/injury prevention to improve body mechanics and increase physical activity without fear of pain-flares and activity avoidance which is central to inactivity in JFM patients. Results will inform the next multi-site RCT in JFM. The Mentoring Plan is to train future clinical investigators in the field of clinical trials and outcoms research in pediatric chronic pain. The candidate's plan consists of 1) individualized mentoring of postdoctoral fellows/junior faculty supported by currently funded studies (longitudinal study in JFM (R01), PROMIS in pediatric pain and rheumatology (U01), a 40-site clinical trial of prevention medication for pediatric migraine (U01), and other ongoing studies, 2) mentoring of fellows/faculty to develop their own independent research and 3) participation of fellows in established didactic programs on manuscript/grant writing, research methodology and responsible conduct of human research. Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research and team-science, presence of an award winning chronic pain program, strong interdisciplinary research collaborations with pediatric rheumatology, pain medicine, sports medicine and neurology researchers interested in pediatric pain, a divisional data core and a commitment of the institution to "change the outcomes" for pediatric patients.

DESCRIPTION (provided by applicant): The Specific Aims of this Midcareer Investigator Award renewal application are to 1) successfully implement an ongoing prospective longitudinal study to determine long term outcomes of pediatric patients with juvenile- onset fibromyalgia (JFM), 2) to refine and test a novel intervention, i.e., combined cognitive-behavioral therapy (CBT) and physical exercise to reduce pain and损害，增加JFM青少年的应对和体育锻炼，以及3）继续使用候选人在小儿疼痛中正在进行的和计划的临床研究来训练博士后研究员和初级教职员工。候选人是一名全国认可的儿科疼痛研究人员，其历史悠久，有10年的独立资助的以患者为导向的研究，重点是针对JFM和其他疼痛状况，纵向研究以及早期职业研究人员的临床治疗临床试验。在目前的K24资金的前3。5年中，她完成了第一次严格控制的试验，表明CBT是减少JFM残疾和抑郁症的安全有效干预措施，并根据JFM和PETIATRIC PAIR研究发表了22篇论文（以及受训者）。该更新应用的拟议研究计划包括两个项目：1）持续的NIAMS（R01）资助了JFM青少年长期结局的纵向研究，以及2）一项正在进行的新型CBT和运动的试验试验 - 适合青少年 - 青少年（纤维肌痛训练）（青少年的纤维级综合训练）。该新计划的创新是，它建立在候选人已建立的CBT计划的基础上，并无缝地整合了从运动中/受伤预防的运动组成部分，以改善身体力学和增加体育锻炼，而不必担心JFM患者无效的止痛和避免活动的避免活动。结果将告知JFM中的下一个多站点RCT。指导计划是在小儿慢性疼痛方面的临床试验和结果研究领域培训未来的临床研究者。候选人的计划包括1）当前资助的研究支持的博士后研究员/初级教师的个性化指导（纵向研究 JFM（R01），小儿疼痛和风湿病学的促进症（U01），一项40个地点的预防药物临床试验，针对小儿偏头痛（U01）（U01）以及其他正在进行的研究，2）指导研究员/教职员工，以制定自己的独立研究和授予人类授权的研究学方法，以培养人的独立研究和授予的方法，并撰写授权的方法，并撰写了授权的方法，并撰写了授权的方法，并撰写了授权的方法，并撰写。 Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research and team-science, presence of an award winning chronic pain program, strong interdisciplinary research collaborations with pediatric rheumatology, pain medicine, sports medicine and neurology researchers interested in pediatric pain, a divisional data core and a commitment of the institution to "change the outcomes" for pediatric patients.