Behavioral Interventions and Long Term Outcomes in Juvenile Fibromyalgia Syndrome

青少年纤维肌痛综合征的行为干预和长期结果

• 批准号: 8126238
• 负责人: Susmita Kashikar-Zuck
• 金额: $ 11.15万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8126238
• 关键词: Adolescence; Adolescent; Award; Behavior Therapy; Child; Childhood; Chronic; Clinical; Clinical Investigator; Clinical Research; Clinical Treatment; Clinical Trials; Cognitive Therapy; Data; Evidence based treatment; Faculty; Fibromyalgia; Funding; Future; Goals; Grant; Headache; Human; Institution; Instruction; Intervention; Longitudinal Studies; Manuscripts; Mentors; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Outcome; Outcomes Research; Pain; Pain Research; Patients; Persistent pain; Postdoctoral Fellow; Primary Fibromyalgias; Public Health; Randomized Clinical Trials; Research; Research Methodology; Research Personnel; Research Proposals; Scientist; Site; Sleep; Training; Translational Research; Writing; chronic pain; data management; effective therapy; efficacy testing; meetings; next generation; outcome forecast; patient oriented research; post-doctoral training; programs; prospective; psychosocial; research study

DESCRIPTION (provided by applicant): The Specific Aims of this Midcareer Investigator Award application are to 1) successfully implement an ongoing randomized clinical trial in juvenile fibromyalgia 2) perform a prospective longitudinal study to determine long term prognosis of pediatric patients with juvenile fibromyalgia, and 3) use the candidate's ongoing and planned studies in the Pediatric Pain Research Program to train post-doctoral fellows and junior faculty in pediatric pain research. The Candidate's programmatic line of research focuses on physical and psychosocial functioning of children and adolescents with chronic pain, with an emphasis on juvenile fibromyalgia syndrome - a very poorly understood chronic pain condition for which there is no evidence- based treatment. The Research Plan includes two projects: a NIAMS funded multi-site randomized clinical trial (ROl) to test the efficacy of cognitive behavioral treatment for children and adolescents with juvenile fibromyalgia, and a longitudinal study of outcomes in juvenile fibromyalgia. The candidate's future plans are to use findings from current projects to develop the most effective treatments for juvenile fibromyalgia and other pediatric pain conditions. The Mentoring Plan is to train future clinical investigators in the field of clinical interventions and outcomes research in pediatric chronic pain. The candidate's plan consists of 1) individualized mentoring of postdoctoral fellows supported by two currently funded clinical trials (Treatment of Juvenile Fibromyalgia, and Chronic Pediatric Headaches), the proposed longitudinal study in juvenile fibromyalgia, and other ongoing clinical and translational research studies in pediatric pain 2) mentoring of fellows to develop their own independent research proposals and 3) participation of fellows in established didactic programs on manuscript and grant writing, clinical research methodology and responsible conduct of human research. Cincinnati Children's provides an ideal setting for this award because of the strong institutional support for patient-oriented research, presence of an award winning chronic pain program, support from the Divisional Data Core for methodological and data management issues, and a commitment of the institution to "change the outcomes" for pediatric patients. RELEVANCE (See Instructions): This study meets the public health goal of better understanding and treating a poorly understood chronic pain condition of childhood (juvenile fibromyalgia) along with the goal of training the next generation of clinician-scientists in clinical and translational research in pediatric pain.

描述（由申请人提供）：该中期研究员奖的申请的具体目的是1）成功实施少年纤维肌痛中正在进行的随机临床试验2）进行一项前瞻性纵向研究，以确定儿科患者的长期预后的长期预后，并使用少年纤维型和3）在候选人的研究中进行培训和3）培训术语的研究，以培训候选人的培训术语，以培训培训的研究，以培训训练的研究，以培训培训的研究，小儿疼痛研究的教师。候选人的计划研究重点是慢性疼痛的儿童和青少年的身体和社会心理功能，重点是青少年纤维肌痛综合征 - 一种非常了解的慢性疼痛状况，没有循证治疗。该研究计划包括两个项目：NIAM资助的多站点随机临床试验（ROL），以测试认知行为治疗对儿童和青少年的少年纤维肌痛的疗效，以及对少年纤维纤维肌痛的结果的纵向研究。候选人的未来计划是利用当前项目的发现来开发针对青少年纤维肌痛和其他儿科疼痛状况的最有效治疗方法。指导计划是在小儿慢性疼痛的临床干预和结果研究领域培训未来的临床研究者。候选人的计划由1）个性化指导博士后研究员组成在既定的关于手稿和赠款写作，临床研究方法论和负责人人类研究的教学课程中。辛辛那提儿童的儿童为该奖项提供了理想的环境，因为对以患者为导向的研究的机构提供了强有力的支持，屡获殊荣的慢性疼痛计划的存在，方法论和数据管理问题的部门数据核心的支持以及该机构“改变儿科患者的成果”的承诺。相关性（请参阅说明）：这项研究符合公共卫生的目标，即更好地理解和治疗儿童期的慢性疼痛状况（少年纤维肌痛），以及培训下一代临床医生在儿科疼痛方面的临床和翻译研究的目标。