Stress and Unintended Pregnancy in Adolescence and Young Adulthood

青春期和青年期的压力和意外怀孕

基本信息

批准号：
8873324
负责人：
Kelli Stidham Hall
金额：
$ 12.79万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-26 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8873324
关键词：
Accounting Address Adolescence Adolescent Adolescent and Young Adult Affect Area Award Behavioral Biological Biological Markers Biological Process Biology Biosocial Chronic stress Complex Contraceptive methods Data Data Set Development Disadvantaged Discipline of obstetrics Distal Doctor of Philosophy Economics Ethnic Origin Event Family Planning Fertility Fertility Determinant Fertility Study Goals Growth Gynecology Health Immune Inequality Inflammatory Institutes Interdisciplinary Study Knowledge Lead Learning Left Life Life Cycle Stages Link Longitudinal Studies Measures Mediation Mentored Research Scientist Development Award Mentors Methods Michigan Minority Minority Groups Modeling Morbidity - disease rate Neurosecretory Systems North Carolina Outcome Pathway interactions Pilot Projects Policies Population Pregnancy Outcome Pregnancy in Adolescence Premature Birth Procedures Process Psychological Stress Public Health Public Health Schools Race Reproductive Health Reproductive Health Services Research Research Infrastructure Research Methodology Research Personnel Research Project Grants Research Training Risk Role Scholarship Shapes Social Environment Societies Socioeconomic Status Sociology Spontaneous abortion Statistical Methods Stress Surveys Techniques Testing Training Translating Universities Ursidae Family Violence Weather Woman Work adverse outcome career development design early childbearing experience hazard health disparity improved innovation insight interdisciplinary approach mortality multidisciplinary multilevel analysis offspring programs prospective psychologic public health relevance racial discrimination reproductive reproductive hormone sex social social disparities social implication social stress socioeconomics stillbirth stressor theories unintended pregnancy young adult young woman

项目摘要

DESCRIPTION (provided by applicant): Adolescent and young adult women in the U.S., especially racial/ethnic minority and poor young women, have high rates of early and unintended pregnancy, which are associated with a host of adverse outcomes. While proximal and distal determinants of fertility have been widely studied, little research has focused on the role of stress in unintended pregnancy. Stress is a leading contributor to morbidity and mortality and a key mechanism that links social context and health disparities. The biological and psychological processes of stress may affect the pathways to unintended pregnancy, but this has not been addressed in reproductive health research. Moreover, how social determinants of stress shape young women's risk of unintended pregnancy is unknown. To improve our knowledge of the complex, interrelated determinants of unintended pregnancy and to advance reproductive health scholarship at the intersection of biological and social processes (i.e. biosocial), this K01 Mentored Research Scientist Development Award focuses on the important but understudied role of stress in unintended pregnancy during adolescence and young adulthood. So that I may conduct cutting-edge research in this area, I propose career development training to: 1) learn sociological theories, concepts, and methods for studying unintended pregnancy and stress; 2) build competency in bio demographic research methods and their application to fertility research; 3) attain a more nuanced understanding of the theory and research on the biology of stress and fecund ability; and 4) become proficient in advanced multilevel, longitudinal, and mediational statistical methods required for modeling the life course of and pathways between stress and unintended pregnancy. The corresponding K01 research project will: 1) estimate how trajectories of stress relate to unintended pregnancy; 2) investigate relationships between social determinants of stress (social stressors), stress trajectories, and unintended pregnancy; and 3) explore the biological processes (e.g., neuroendocrine, inflammatory, and immune) through which stress influences unintended pregnancy, during adolescence and young adulthood. To assist with the K01 training and research plans, I have assembled a strong multidisciplinary advisory board comprised of esteemed scholars, including mentor Jennifer Barber PhD, co-mentor Kathleen Mullan Harris PhD, scientific advisors Ana Diez Roux MD PhD, Timothy Johnson MD, and Julia Seng PhD MSN, and statistical consultant Yu Xie PhD. The University of Michigan Department of Obstetrics and Gynecology and Institute for Social Research and The University of North Carolina at Chapel Hill School of Public Health and Carolina Population Center will provide the infrastructures to support these activities. This K01 will establish me as an independent investigator poised to conduct new biosocial studies of fertility and ultimately lead innovative, interdisciplinary research efforts to improve outcomes an reduce disparities in young women's reproductive health.

描述（由申请人提供）：美国的青春期和年轻成年女性，尤其是少数族裔和贫困年轻女性，早孕和意外怀孕的比例很高，这与一系列不良后果相关。生育力的影响已被广泛研究，但很少有研究关注压力在意外怀孕中的作用。压力是发病率和死亡率的主要原因。压力的生物和心理过程可能会影响意外怀孕的途径，但生殖健康研究尚未解决压力的社会决定因素如何影响年轻女性的风险。为了提高我们对意外怀孕复杂且相互关联的决定因素的认识，并促进生物和社会过程（即生物社会）交叉领域的生殖健康研究，设立了 K01 指导研究科学家发展奖。重点关注压力在青春期和青年期意外怀孕中的重要但尚未得到充分研究的作用，以便我可以在这一领域进行前沿研究，我建议职业发展培训：1）学习社会学理论、概念和研究方法。意外怀孕和压力；2）培养生物人口研究方法及其在生育研究中的应用能力；3）对压力和生育能力的生物学理论和研究有更细致的了解；生命历程建模所需的先进多层次、纵向和中介统计方法相应的 K01 研究项目将：1) 估计压力轨迹与意外怀孕的关系；2) 调查压力与意外怀孕之间的关系。压力的社会决定因素（社会压力源）、压力轨迹和意外怀孕之间的关系；3）探索压力在青春期和成年早期影响意外怀孕的生物过程（例如神经内分泌、炎症和免疫）。通过 K01 培训和研究计划，我组建了一个强大的多学科顾问委员会，由受人尊敬的学者组成，包括导师 Jennifer Barber 博士、共同导师 Kathleen Mullan Harris 博士、科学顾问Ana Diez Roux 医学博士、Timothy Johnson 医学博士和 Julia Seng 博士 MSN，以及密歇根大学妇产科和社会研究所以及北卡罗来纳大学教堂山公共卫生学院统计顾问 Yu Xie 博士。卡罗莱纳州人口中心将提供基础设施来支持这些活动，K01 将使我成为一名独立调查员，准备开展新的生育力生物社会研究，并最终领导创新的跨学科研究工作，以改善结果并减少年轻人的差异。妇女的生殖健康。