MRI & CT studies of the developing vocal tract

核磁共振成像

• 批准号: 8865589
• 负责人: HOURI Kaloustian VORPERIAN
• 金额: $ 61.81万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8865589
• 关键词: Accounting; Achievement; Acoustics; Address; Adult; Advocate; Age; Algorithms; Anatomy; Asses; Behavior; Birth; Cartilage; Child; Clinical; Consent; Data; Databases; Deglutition; Development; Discipline; Down Syndrome; Foundations; Genetic; Goals; Growth; Head and neck structure; Health; Histocompatibility Testing; Hyoid bone structure; Image; Impairment; Individual; Intervention; Investigation; Joints; Larynx; Length; Longevity; Magnetic Resonance Imaging; Mandible; Measurement; Measures; Medical Imaging; Methods; Mission; Modeling; Morphology; Nature; Oral; Oropharyngeal; Output; Participant; Pattern; Pharyngeal structure; Physiology; Process; Production; Property; Relative (related person); Research; Respiration; Sampling; Secure; Shapes; Source; Specific qualifier value; Speech; Speech Acoustics; Speech Development; Speech Disorders; Speech Sound; Statistical Methods; Structure; System; Testing; Tissues; Width; Work; X-Ray Computed Tomography; acoustic imaging; base; clinical application; craniofacial; craniofacial development; design; early childhood; feeding; improved; medical specialties; novel; postnatal; prenatal; sex; sexual dimorphism; soft tissue; sound; theories; three-dimensional modeling; trend; two-dimensional

DESCRIPTION (provided by applicant): The growth of the oral and pharyngeal structures and their respective cavities - that define the vocal tract (VT) - follow a prenatal to postnatal developmental continuum. Current theory asserts that postnatal growth of the VT is guided by the functions it serves, especially for the period from birth to early childhood where growth entails changes in size, shape, and relative proportions. Acoustic theory posits an evolving relationship between the VT anatomy and the properties of speech sounds during development. The available anatomic information is inadequate to explain the full nature of this relationship. Since 2000, our VT Development Lab has made steady progress towards its mission to quantitatively characterize sex-specific anatomic changes of the supralaryngeal speech system during development using a two-pronged anatomic-acoustic approach that entails: A. Anatomy: 1) Establishing a unique imaging database, consisting of 1679 imaging studies across the lifespan, that is representative of typically developing individuals of both sexes. 2) Compiling a large set of two dimensional landmark based measurements that capture the concurrent growth of the VT structures throughout the lifespan; and advancing novel analysis methods using select 3D models to quantify multidimensional growth (Chung et al. 2013, submitted) 3) Characterizing systematically the individual and relational growth of VT structures (Vorperian et al. 1999, 2005, 2007, 2009 & 2011). B. Acoustic: 1) Synthesizing findings on the development of vowel acoustic space i.e. the acoustic output of the developing VT (Vorperian & Kent, 2007). 2) Synthesizing findings on speech impairment in DS to help guide future research efforts (Kent & Vorperian, 2013). 3) Beginning to establish an acoustics database consisting of recordings from 250 participants including 90 individuals with Down Syndrome (DS) between the ages four to adulthood; and 4) Compiling developmental acoustics data including measures of the first four formants and their bandwidths. This proposed project combines imaging, acoustics, and VT modeling to study the development of the supra-laryngeal speech apparatus throughout the lifespan within the theoretical construct on function driven craniofacial growth. Research goals are to: 1) Capitalize on the imaging database to quantify the 3D growth of individual, relative and relational growth of VT structures while taking into account the structures' tissue type (bony, soft, cartilage and cavity), embryologic origin, plane of growth, and/or functional use. Also, extend our acoustics database while addressing fundamental issues in acoustic analysis. 2) Assess hypotheses that are acoustically driven and/or guided by structure/function interplay using typically and atypically developing individuals; and 3) Use age and sex-specific VT models to test hypotheses on anatomic-acoustic relationships. Project findings will provide a coherent and much needed picture on the development of VT structures throughout the lifespan. Such information is foundational for both theoretical constructs and clinical application in multiple disciplines that deal with craniofacial structures and functions.

描述（由申请人提供）：口腔和咽部结构及其各自的腔体（定义声道（VT））的生长遵循产前到产后的发育连续体。目前的理论认为，VT 的出生后生长是由其所发挥的功能引导的，特别是从出生到幼儿期，此时生长需要尺寸、形状和相对比例的变化。声学理论假定 VT 解剖结构与发育过程中语音特性之间存在不断变化的关系。现有的解剖学信息不足以解释这种关系的全部性质。自 2000 年以来，我们的 VT 开发实验室在实现其使命方面取得了稳步进展，即使用双管齐下的解剖声学方法定量描述开发过程中喉上语音系统的性别特异性解剖变化，该方法需要： A. 解剖学： 1) 建立独特的成像数据库，由 1679 个整个生命周期的成像研究组成，代表了典型发育的两性个体。 2) 编制大量基于二维地标的测量数据，捕获 VT 结构在整个生命周期中的并发增长；并使用选定的 3D 模型推进新颖的分析方法来量化多维增长（Chung 等人，2013 年，已提交）3）系统地表征 VT 结构的个体和相关增长（Vorperian 等人，1999、2005、2007、2009 和 2011）。 B. 声学：1) 综合元音声学空间发展的发现，即发展中的 VT 的声学输出（Vorperian & Kent，2007）。 2) 综合 DS 言语障碍的研究结果，以帮助指导未来的研究工作（Kent & Vorperian，2013）。 3) 开始建立一个声学数据库，包含 250 名参与者的录音，其中包括 90 名 4 岁至成年唐氏综合症 (DS) 患者； 4) 编译发育声学数据，包括前四个共振峰及其带宽的测量。该项目结合了成像、声学和 VT 建模，在功能驱动颅面生长的理论框架内研究喉上言语器官在整个生命周期中的发展。研究目标是： 1) 利用成像数据库量化 VT 结构的个体、相对和关系生长的 3D 生长，同时考虑结构的组织类型（骨、 软、软骨和空腔）、胚胎起源、生长平面和/或功能用途。此外，扩展我们的声学数据库，同时解决声学分析中的基本问题。 2) 使用典型和非典型发育个体评估由结构/功能相互作用在声学上驱动和/或指导的假设； 3) 使用年龄和性别特定的 VT 模型来检验解剖学-声学关系的假设。 项目研究结果将为 VT 结构在整个生命周期的发展提供一个连贯且急需的图景。这些信息是处理颅面结构和功能的多个学科的理论构建和临床应用的基础。