MRI & CT studies of the developing vocal tract

核磁共振成像

• 批准号: 9097675
• 负责人: HOURI Kaloustian VORPERIAN
• 金额: $ 61.15万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9097675
• 关键词: Accounting; Achievement; Acoustics; Address; Adult; Advocate; Age; Algorithms; Anatomy; Asses; Behavior; Birth; Cartilage; Child; Clinical; Consent; Data; Databases; Deglutition; Development; Discipline; Down Syndrome; Foundations; Genetic; Goals; Growth; Head and neck structure; Health; Histocompatibility Testing; Hyoid bone structure; Image; Impairment; Individual; Intervention; Investigation; Joints; Larynx; Length; Longevity; Magnetic Resonance Imaging; Mandible; Measurement; Measures; Medical Imaging; Methods; Mission; Modeling; Morphology; Nature; Oral; Oropharyngeal; Output; Participant; Pattern; Pharyngeal structure; Physiology; Process; Production; Property; Research; Respiration; Sampling; Secure; Shapes; Source; Specific qualifier value; Speech; Speech Acoustics; Speech Development; Speech Disorders; Speech Sound; Statistical Methods; Structure; System; Testing; Tissues; Width; Work; X-Ray Computed Tomography; acoustic imaging; base; clinical application; control theory; craniofacial; craniofacial development; design; early childhood; feeding; improved; laboratory development; medical specialties; novel; postnatal; prenatal; sex; sexual dimorphism; soft tissue; sound; theories; three-dimensional modeling; trend; two-dimensional

DESCRIPTION (provided by applicant): The growth of the oral and pharyngeal structures and their respective cavities - that define the vocal tract (VT) - follow a prenatal to postnatal developmental continuum. Current theory asserts that postnatal growth of the VT is guided by the functions it serves, especially for the period from birth to early childhood where growth entails changes in size, shape, and relative proportions. Acoustic theory posits an evolving relationship between the VT anatomy and the properties of speech sounds during development. The available anatomic information is inadequate to explain the full nature of this relationship. Since 2000, our VT Development Lab has made steady progress towards its mission to quantitatively characterize sex-specific anatomic changes of the supralaryngeal speech system during development using a two-pronged anatomic-acoustic approach that entails: A. Anatomy: 1) Establishing a unique imaging database, consisting of 1679 imaging studies across the lifespan, that is representative of typically developing individuals of both sexes. 2) Compiling a large set of two dimensional landmark based measurements that capture the concurrent growth of the VT structures throughout the lifespan; and advancing novel analysis methods using select 3D models to quantify multidimensional growth (Chung et al. 2013, submitted) 3) Characterizing systematically the individual and relational growth of VT structures (Vorperian et al. 1999, 2005, 2007, 2009 & 2011). B. Acoustic: 1) Synthesizing findings on the development of vowel acoustic space i.e. the acoustic output of the developing VT (Vorperian & Kent, 2007). 2) Synthesizing findings on speech impairment in DS to help guide future research efforts (Kent & Vorperian, 2013). 3) Beginning to establish an acoustics database consisting of recordings from 250 participants including 90 individuals with Down Syndrome (DS) between the ages four to adulthood; and 4) Compiling developmental acoustics data including measures of the first four formants and their bandwidths. This proposed project combines imaging, acoustics, and VT modeling to study the development of the supra-laryngeal speech apparatus throughout the lifespan within the theoretical construct on function driven craniofacial growth. Research goals are to: 1) Capitalize on the imaging database to quantify the 3D growth of individual, relative and relational growth of VT structures while taking into account the structures' tissue type (bony, soft, cartilage and cavity), embryologic origin, plane of growth, and/or functional use. Also, extend our acoustics database while addressing fundamental issues in acoustic analysis. 2) Assess hypotheses that are acoustically driven and/or guided by structure/function interplay using typically and atypically developing individuals; and 3) Use age and sex-specific VT models to test hypotheses on anatomic-acoustic relationships. Project findings will provide a coherent and much needed picture on the development of VT structures throughout the lifespan. Such information is foundational for both theoretical constructs and clinical application in multiple disciplines that deal with craniofacial structures and functions.

描述（由申请人提供）：口服和咽结构的生长及其各自的空腔 - 定义声带（VT） - 遵循产后到产后发育连续性的产前。当前的理论断言，VT的产后生长受到其所提供的功能的指导，尤其是在从出生到幼儿期间，增长需要变化的大小，形状和相对比例的变化。声学理论提出了VT解剖学与发育过程中语音的特性之间不断发展的关系。可用的解剖信息不足以解释这种关系的全部性质。自2000年以来，我们的VT开发实验实验室已稳步进步，朝着定量表征性别特异性解剖学变化在开发过程中使用两管齐下的解剖声学方法进行定量特异性解剖变化，该方法需要：A。解剖学：1）建立独特的独特成像数据库，由整个生命周期的1679个成像研究组成，代表了通常发展两个性别的个体。 2）编译一组基于二维地标的测量值，这些测量值捕获整个寿命的VT结构的同时生​​长；并使用精选的3D模型来量化多维生长（Chung等人，2013年，提交）3）系统地表征VT结构的个体和关系增长（Vorperian等，1999，2005，2007，2009＆2011）。 B.声学：1）关于元音声学空间发展的合成发现，即发育中的VT的声学输出（Vorperian＆Kent，2007年）。 2）综合DS中语音障碍的发现，以帮助指导未来的研究工作（Kent＆Vorperian，2013年）。 3）开始建立一个由250名参与者的录音组成的声学数据库，其中包括90名唐氏综合症（DS）在四岁至成年之间； 4）编译发展声学数据，包括前四个实力及其带宽的度量。该提出的项目结合了成像，声学和VT建模，以在整个寿命中研究型颅面生长的理论结构中的整个生命周期中的超脑词性。研究目标是：1）利用成像数据库，以量化VT结构的个体，相对和关系增长的3D增长，同时考虑到结构的组织类型（Bony，Bony， 软，软骨和空腔），胚胎学起源，生长平面和/或功能用途。另外，在解决声学分析中解决基本问题的同时，扩展了我们的声学数据库。 2）评估通过典型和非典型发展个体的结构/功能相互作用来驱动和/或引导声学驱动和/或指导的假设； 3）使用年龄和性别特定的VT模型来测试有关解剖声学关系的假设。 项目发现将为整个生命周期的VT结构的开发提供一致且急需的图片。此类信息是理论构造和临床应用的基础，这些学科涉及颅面结构和功能的多个学科。