A Self-Assembling Gel with Antimicrobial and Antioxidant Properties for the Treat

具有抗菌和抗氧化特性的自组装凝胶，用于治疗

基本信息

批准号：
8597978
负责人：
DAVID J VACHON
金额：
$ 34.92万
依托单位：
NOVION TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-20 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8597978
关键词：
Accounting Acetates Animal Model Antibiotics Antioxidants Bacteria Burn injury Cessation of life Characteristics Complex Complication Cream Dermal Development Dose Drug Formulations Effectiveness Environment Erythema Evaluation Fibroblasts Free Radicals Gel Glutathione Goals Granulation Tissue Healed Histocompatibility Hydrogels Imagery In Vitro Individual Infection Inflammation Light Lipid Peroxidation Lipids Liquid substance Maintenance Measurement Methicillin Resistance Microbial Biofilms Modeling Nature Ointments Oxidative Stress Patients Performance Peroxidases Phase Preparation Process Production Property Pseudomonas aeruginosa Rattus Reactive Oxygen Species Reduced Glutathione Research Resolution Running Sepsis Silver Solubility Solutions Staphylococcus aureus Sterile coverings Sulfadiazine TNF gene Technology Testing Therapeutic Thick Tissues Topical Antibiotic Topical agent Toxic effect Toxin Treatment outcome Work Wound Healing antimicrobial antimicrobial drug base biomaterial compatibility carbene design healing improved in vivo innovation leukocyte activation microbial microbicide novel pathogen programs protein complex public health relevance resistant strain scale up wound

项目摘要

DESCRIPTION (provided by applicant): Three novel uncharged silver microbicides have been shown to be effective against a wide variety of pathogens have been shown to spontaneously form amorphous hydrogels when combined with glutathione will be formulated into two different ointment formulations and tested in an infected burn wound model in the rat. Formulation of the silver microbicides will be conducted at different concentrations for evaluation. The major specific aims of the proposed research involve the preparation & formulation/processing of the silver microbicides, determination of antimicrobial capacity, cyto-compatability, and evaluation in an infected burn wound model in the rat. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) improvement of healing, and 3. reduction in overall oxidative stress. This innovative and rational approach to a topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bioapplicable attributes of these silver microbicide complexes. The end-goal of this project is to enable the next phase of development of one or more of these novel microbicidal formulations that will be targeted for the treatment of burn wounds while developing a greater understanding of the mechanisms by which these compounds work.

描述（由申请人提供）：三种新型不带电银杀菌剂已被证明可有效对抗多种病原体，与谷胱甘肽结合时可自发形成无定形水凝胶，将被配制成两种不同的软膏配方并在受感染的烧伤中进行测试大鼠伤口模型。将在不同浓度下配制银杀菌剂以进行评估。拟议研究的主要具体目标涉及银杀菌剂的制备和配方/加工、抗菌能力的测定、细胞相容性以及评价大鼠感染烧伤伤口模型。所提议疗法的主要目标是：1) 解决感染，2) 改善愈合，以及 3. 减少总体氧化应激。这种创新且合理的局部抗菌治疗方法是建立在多项不同研究的基础上的，这些研究揭示了这些银杀菌剂复合物具有良好的生物应用特性。该项目的最终目标是能够在下一阶段开发一种或多种新型杀菌制剂，这些制剂将用于治疗烧伤创面，同时加深对这些化合物作用机制的了解。