2014 Cardiac Regulatory Mechanisms Gordon Research Conference & Gordon Research S

2014年心脏调节机制戈登研究会议

• 批准号: 8784793
• 负责人: MARK E ANDERSON
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-05 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8784793
• 关键词: Area; Arrhythmia; Cardiac; Cardiac Myocytes; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Treatment; Data; Development; Diagnosis; Discipline; Disease; Ensure; Fostering; Functional disorder; Funding; Future; Genetic; Genetic Models; Genetically Modified Animals; Geography; Health; Heart; Human; Human Genetics; Image; Information Technology; Ion Channel; Ions; Knockout Mice; Learning; Mechanics; Medicine; Mentors; MicroRNAs; Mitochondria; Modeling; Molecular; Muscle Cells; Nature; Oral; Oxidation-Reduction; Participant; Phenotype; Physiology; Postdoctoral Fellow; Prevention; Process; Property; Publications; Published Comment; Recruitment Activity; Regulation; Research; Research Personnel; Role; Science; Scientist; Signal Pathway; Signal Transduction; Social Interaction; Source; Staging; Techniques; Time; Transgenic Mice; Translating; Translations; Work; abstracting; base; career; college; drug development; experience; field study; graduate student; induced pluripotent stem cell; innovation; interest; mouse model; new technology; next generation; novel; planetary Atmosphere; posters; public health relevance; symposium; tool

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon research Conference (GRC) and the Gordon Research Seminar (GRS) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 7-13, 2014. For over 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. The common interest is the topic of regulation of the normal and diseased heart with a focus on specific regulatory mechanisms that can be translated to novel therapies. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including application of iPS cells to model human myocardial disease, mitochondrial Ca2+ regulation, redox regulation, subcellular compartments and their real time imaging. Other sessions focus on arrhythmias, Ca2+ signaling in myocytes, and emerging techniques to advance our field of study. Discussion leaders promote lively discussions and critical questioning. A key objective of this conference is to foster an inclusive, intensive, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of resolved issues. The inclusiveness of this conference in 2012 was enhanced by the GRS, a mechanism for highlighting work by graduate students and post-doctoral trainees. The GRS was well-received and will be held immediately prior to the GRC at Colby-Sawyer College. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies, including iPS cells that allow us to explore the cellular and molecular basis of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect that the proposed presentations will be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience.

描述（由申请人提供）： 该申请为戈登研究会议（GRC）和戈登研究研讨会（GRS）寻求部分资金，旨在在2014年6月7日至13日在Colby Sawyer College（NH Colby-Sawyer，NH）举行的心脏监管机制。25年以上，该会议为新的调查师和社交者提供了群体和社会的培训，并始终如一地培养了他们的互动和社交，并培养了他们的互动型，并始终如一地培养了他们的互动和既定的，并始终如一地培养了自己的互动。 GRC的非正式性质在培养跨越学科和地理的讨论中是独一无二的，并使新的个人和科学联系能够发展。参与者是从职业生涯和各种学科的所有阶段中最有前途，最有生产力的科学家中选择的。共同的兴趣是调节正常和患病心脏的主题，重点是可以转化为新疗法的特定调节机制。在这些过程中，我们具有与正常心脏电气和机械性能，心肌细胞信号传导和异常相关的基本科学的良好结合，这些过程会导致心脏功能障碍。转基因动物的使用增加以及确定的心血管表型的发展使心血管系统可拖拉，从而引起了细胞信号传导场的广泛和扩展。今年的会议特别关注信号通路，包括一些强烈的研究兴趣的新领域，包括应用IPS细胞在人体心肌疾病，线粒体CA2+调节，氧化还原调节，亚细胞隔室及其实时成像中的应用。其他课程的重点是心律不齐，心肌细胞中的Ca2+信号传导以及新兴技术，以推进我们的研究领域。讨论领导者促进了活泼的讨论和批判性质疑。这次会议的关键目标是培养包容性， 密集，活泼和互动的氛围突出了争议，并通过对解决问题有更深入的了解来启发参与者。 GRS增强了2012年这次会议的包容性，GRS是一种强调研究生和博士后学员工作的机制。 GRS受到了良好的欢迎，将在Colby-Sawyer College的GRC之前立即举行。在心血管科学中，这是一个令人兴奋的时刻，因为使用了转基因和基因敲除小鼠模型，遗传信息和新技术，包括IPS细胞，使我们能够探索正常心脏功能的细胞和分子基础。我们开始将这些新发现转化为对疾病机制，诊断，预防和治疗的更好理解。我们预计拟议的演讲将既令人兴奋又及时，并通过从海报贡献和最新出版物中招募发言人来包括晚期的闯入科学和年轻调查人员。这是那些经常参加会议的人，新的与会者和年轻科学家认为是无价的学习和职业经验。