2012 Cardiac Regulatory Mechanisms Gordon Research Conference and Gordon Research

2012年心脏调节机制戈登研究会议和戈登研究

• 批准号: 8316613
• 负责人: MARK E ANDERSON
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8316613
• 关键词: Area; Arrhythmia; Biological Models; Cardiac; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular system; Charge; Clinical; Clinical Treatment; Consensus; Data; Development; Diagnosis; Discipline; Disease; Ensure; Fostering; Functional disorder; Funding; Genetic; Genetically Modified Animals; Geography; Health; Heart; Heart Diseases; Image; Information Technology; Ion Channel; Ions; Knockout Mice; Lead; Learning; Mechanics; Mentors; Mitochondria; Molecular; Muscle Cells; Nature; Oral; Oxidation-Reduction; Participant; Phenotype; Phosphorylation; Phosphotransferases; Physiology; Prevention; Process; Property; Publications; Recruitment Activity; Regulation; Research; Research Personnel; Resolution; Role; Science; Scientist; Signal Pathway; Signal Transduction; Social Interaction; Source; Staging; Time; Transgenic Mice; Translating; Translations; base; career; college; experience; innovation; interest; mouse model; new technology; next generation; novel; novel therapeutics; planetary Atmosphere; posters; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) and the Gordon Research Seminar (GRS) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 9-15, 2012. For more than 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The special informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Accordingly, an extraordinarily high number of scientists return to this conference year after year. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. Their bond is a common interest in the topic of regulation of the normal and diseased heart with a focus on Ca2+ regulatory mechanisms. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including mitochondrial Ca2+ regulation, redox regulation, new model systems, subcellular compartments and their real time imaging. Other sessions focus on arrhythmias, Ca2+ signaling in myocytes, and novel signaling pathways. Discussion leaders are charged with and are historically successful at promoting lively discussions and critical questioning. Indeed a key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of unresolved issues. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies that allow us to explore the cellular and molecular basis of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect that the proposed presentations will be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience.

描述（由申请人提供）：本申请为戈登研究会议（GRC）和戈登研究研讨会（GRS）寻求部分资金社交互动。 GRC的特殊非正式性质在促进跨越学科和地理的讨论中是独一无二的，并使新的个人和科学联系得以发展。因此，一年一度的科学家数量非常高。参与者是从职业生涯和各种学科的所有阶段中最有前途，最有生产力的科学家中选择的。他们的纽带是 对正常和患病心脏的调节主题的共同兴趣，重点是CA2+调节机制。在这些过程中，我们具有与正常心脏电气和机械性能，心肌细胞信号传导和异常相关的基本科学的良好结合，这些过程会导致心脏功能障碍。转基因动物的使用增加以及确定的心血管表型的发展使心血管系统可拖拉，从而引起了细胞信号传导场的广泛和扩展。今年的会议特别关注信号通路，包括一些新的强烈研究兴趣领域，包括线粒体CA2+调节，氧化还原调节，新模型系统，亚细胞隔室及其实时成像。其他课程集中于心律不齐，心肌细胞中的Ca2+信号传导以及新颖的信号通路。讨论负责人被指控，并在历史上成功地促进了活泼的讨论和批判性质疑。确实，这次会议的关键目标是培养一种包容性，强烈，生动和互动性的氛围，该氛围突出了争议，并通过对未解决的问题有更深入的了解来启发参与者。在心血管科学中，这是一个令人兴奋的时刻，因为使用了转基因和基因敲除小鼠模型，遗传信息和新技术，使我们能够探索正常心脏功能的细胞和分子基础。我们开始将这些新发现转化为对疾病机制，诊断，预防和治疗的更好理解。我们预计拟议的演讲将既令人兴奋又及时，并通过从海报贡献和最新出版物中招募发言人来包括晚期的闯入科学和年轻调查人员。这是那些经常参加会议的人，新的与会者和年轻科学家认为是无价的学习和职业经验。