Compressed Sensing 5D Spectroscopic Imaging of Perinatally HIV-Infected Youth

围产期 HIV 感染青少年的压缩感知 5D 光谱成像

基本信息

批准号：
8551779
负责人：
MICHAEL Albert THOMAS
金额：
$ 20.42万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-30 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8551779
关键词：
Acquired Immunodeficiency Syndrome Adult Age Age-Years Algorithms Anisotropy Anti-Retroviral Agents Applications Grants Aspartate Brain Brain Injuries Brain imaging Brain region CD4 Lymphocyte Count Cerebrum Child Childhood Choline Chronic Chronic Brain Injury Clinical Code Cognitive Corpus Callosum Creatine Data Deterioration Development Diffusion Diffusion Magnetic Resonance Imaging Dimensions Evaluation Exposure to Four-dimensional Future Glutamates Glutathione Goals HIV Health Hippocampus (Brain)Home environment Imaging Techniques Individual Infection Inositol Intervention Knowledge Lead Location Long-Term Effects Longitudinal Studies Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measurement Measures Medical Imaging Motor N-acetylaspartate Nervous System Physiology Neuraxis Neurodegenerative Disorders Neuronal Injury Neuropathogenesis One-Step dentin bonding system Outcome Pathogenesis Patients Pharmaceutical Preparations Play Population Process Protocols documentation Psychomotor Performance Quality of life Radial Reporting Resolution Role Sampling Scheme Signal Transduction Slice Spectrum Analysis Speed Survivors Techniques Testing Thick Time Treatment Effectiveness Viral Load result Virus Diseases Work Youth base caudate nucleus clinical application cohort data acquisition efficacy evaluation executive function gray matter improved innovation lateral ventricle motor impairment neurochemistry neurocognitive test neuroimaging neuroinflammation neuropsychological new technology novel prevent reconstruction scyllo-inositol sex spectroscopic imaging tool two-dimensional white matter

项目摘要

DESCRIPTION (provided by applicant): Brain abnormalities occur in HIV-infected individuals (adults and children) despite highly active antiretroviral treatment. Hence, noninvasive neuroimaging tools could assess the effectiveness of these treatments in preserving brain health and possibly lead to improvements in therapy. One-dimensional (1D) MR Spectroscopy (MRS) usually enables study of only six cerebral metabolites due to limited spectral dispersion even with 3 Tesla MRI scanners. Recently, more than fifteen cerebral metabolites have been quantified non-invasively in the prefrontal dorsolateral white matter region of perinatally HIV-infected youth and healthy children including novel metabolites such as glutathione (GSH), aspartate (Asp) and scyllo-inositol using the home-developed two-dimensional (2D) localized correlated spectroscopy (L-COSY) sequence combined with the prior-knowledge fitting (ProFit) algorithm. However, the requirement of a bigger voxel (27ml) and longer acquisition times were major limitations. Hence, two novel four-dimensional (4D) multi-voxel based 2D MRS sequences, namely echo-planar J-resolved spectroscopic imaging (EP-JRESI) and echo-planar correlated spectroscopic imaging (EP-COSI) were recently implemented by our group where two spectroscopic dimensions were combined with two spatial dimensions. Previously, due to the required number of encoding steps for one of the spatial and the spectral dimensions, a total duration of approximately 30 minutes was necessary. The feasibility of enhancing the speed of MRI/MRSI and diffusion tensor imaging (DTI) using non uniform sampling (NUS) or sparse sampling along selected spatial and spectral dimensions using compressed sensing (CS) based reconstruction has recently been demonstrated. Hence, the proposed study will test the following hypotheses: 1) The NUS-based five-dimensional (5D) EP-JRESI data acquisition and CS-based reconstruction will shorten the total acquisition duration by at least 8 fold, improving clinical applicability, ad will offer similar spectral and spatial resolution. 2) DTI will show higher radial and axial diffuson (reflecting neuroinflammation) and lower fractional anisotropy (reflecting neuronal injury) in multiple brain regions as markers of microstructural abnormalities in the brains of perinatally HIV-infected youths (a population not yet studied using DTI). Three specific goals are proposed: 1) to optimize the 5D EP-JRESI sequence on a 3T MRI scanner in which NUS will be incorporated into 2 spatial and 1 spectral dimensions, and to further optimize the CS-based reconstruction of the 5D MRSI data using home developed MATLAB code; 2) to acquire multi-voxel 2D J-resolved spectra and 3D spectroscopic images of cerebral metabolites in HIV-infected and age/sex matched healthy youths; 3) to record DTI of the brain and to correlate DTI measures with metabolite ratios and other HIV disease variables. The ongoing brain injury will be assessed in perinatally HIV- infected youth compared to healthy youths. This novel technology may also be extended to adult HIV and will also permit improved brain assessments for other degenerative neurologic diseases.

描述（由申请人提供）：尽管高度活跃的抗逆转录病毒治疗，但艾滋病毒感染的个体（成人和儿童）仍会发生脑异常。因此，无创神经影像学工具可以评估这些治疗方法在保存脑健康方面的有效性，并可能导致治疗的改善。一维（1D）MR光谱法（MRS）通常可以研究由于光谱散布有限，即使使用3台Tesla MRI扫描仪，因此仅研究6个脑代谢物。最近，超过15个脑代谢产物已在围另一个前外侧白质区域中进行了非侵入性量化，包括谷胱甘肽（GSH），Aspartate（asp）（ASP）和Scyllo-Insitolate（使用本地式的两二维型）（2d-dimensientionallatientionallatientionallatientionallatiention）序列结合了先前的知识拟合（利润）算法。但是，更大的体素（27毫升）和更长的获取时间的要求是主要局限性。因此，两个新型的四维（4D）基于多素的2D MRS序列，即回声平面J分解的光谱成像（EP-JRESI）（EP-JRESI）和回波相关光谱成像（EP-COSI）最近由我们组实现了两种光谱差异。以前，由于空间和光谱尺寸之一所需的编码步骤数，因此总持续时间约为30分钟。最近已证明，使用基于压缩感测（CS）重建的非均匀采样（NUS）（NUS）（NUS）或稀疏采样，提高MRI/MRSI和扩散张量成像（DTI）的速度的可行性。因此，拟议的研究将检验以下假设：1）基于NUS的五维（5D）EP-JRESI数据采集和基于CS的重建将使总获取持续时间缩短至少8倍，从而提高了临床适用性，AD将提供相似的光谱和空间分辨率。 2）DTI将显示出较高的径向和轴向扩散（反映神经炎症）和较低的分数各向异性（反映了神经元损伤）在多个大脑区域中，这是围绕perinatial perinatial HIV感染的年轻人（尚未使用DTI尚未研究的人群）的微观结构异常的标记。提出了三个特定目标：1）在3T MRI扫描仪上优化5D EP-JRESI序列，其中NUS将在其中将NUS纳入2个空间和1个频谱维度，并进一步优化基于CS的5D MRSI数据的基于CS基于HOME DATA的重建。 2）在HIV感染和年龄/性别相匹配的健康青年中获得多伏氧化2D J分辨光谱和3D光谱图像； 3）记录大脑的DTI并将DTI测量与代谢物比和其他HIV疾病变量相关联。与健康的年轻人相比，将在围产期艾滋病毒感染的青年中评估持续的脑损伤。这项新型技术也可以扩展到成人艾滋病毒，还将允许改善其他退化性神经系统疾病的大脑评估。