Cancer Nanotechnology in Imaging and Radiotherapy

癌症纳米技术在成像和放射治疗中的应用

基本信息

批准号：
8544400
负责人：
GAYLE E. WOLOSCHAK
金额：
$ 40.98万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-25 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8544400
关键词：
Academia Address Administrator Advisory Committees Angiogenesis Inhibitors Animal Model Animals Applications Grants Area Basic Science Binding Biochemical Biological Products Biology Blood capillaries Brain Neoplasms CCNE1 gene Cancer Center Cancer Detection Carbon Nanotubes Cell model Cells Characteristics Chemicals Chemistry Chicago Clinical Clinical Oncology Clinical Research Clinical Trials Collaborations Complex Conceptions Conduct Clinical Trials Contrast Media Coupled Dendrimers Detection Development Devices Discipline Education Engineering Enrollment Environment Evaluation Exhibits Exposure to Eye Faculty Familiarity Feedback Foundations Fruit Funding Future Gadolinium Generations Gold Heating Human Human body Hydrogels Image Imaging Device Institution Integrins Ions Knowledge Laboratories Language Lesion Light Link Location Magnetic Resonance Imaging Magnetism Malignant Neoplasms Malignant neoplasm of brain Malignant neoplasm of prostate Manuscripts Master of Science Medical Metastatic Lesion Metastatic Neoplasm to the Bone Methodology Methods Michigan Mission Missouri Molecular Monitor Nanotechnology Nature Normal tissue morphology Outpatients Pathway interactions Patients Performance Pharmaceutical Preparations Pharmacology Phase Photochemotherapy Physics Physiological Play Positioning Attribute Preclinical Testing Private Sector Process Property Prostatic Neoplasms Publications Publishing Quantum Dots Radiation Oncologist Radiation Oncology Radiation therapy Radiation-Sensitizing Agents Radiology Specialty Research Research Personnel Research Project Grants Research Training Residencies Robert H Lurie Comprehensive Cancer Center of Northwestern University Roentgen Rays Role Roswell Park Cancer Institute Safety Scientist Signal Transduction Site Specificity Spottings Staging Technology Temperature Testing Therapeutic Therapeutic Agents Training Training Program for Cancer Prevention and Control Scientists (R25)Training Programs Translating Translations Tumor Biology Ultrasonography Universities Virginia Washington Writing abstracting angiogenesis base bench to bedside cancer cell cancer diagnosis cancer imaging cancer therapy capillary career development cellular oncology chemoradiation chemotherapy clinical application clinical practice design direct application doctoral student experience gadolinium oxide grasp image guided therapy imaging modality in vivo iron oxide magnetic field medical specialties meetings melting member molecular imaging multidisciplinary nano nanodevice nanomaterials nanoparticle nanoparticulate nanoscale nanosized nanovector neoplastic cell neovascular novel oncology service optical imaging particle physical property pre-clinical preclinical study programs radiologist response skills success therapeutic target tool tumor

项目摘要

DESCRIPTION (provided by applicant): This is the second revision of a proposal to establish an R25T cancer education and career development program, Cancer Nanotechnology in Imaging and Radiotherapy. Radiology and radiation oncology are clinical specialties that are heavily used for cancer diagnosis and treatment and that are likely to be revolutionized by advances in nanotechnology. For the fruits of nanotechnology research to benefit patients who are receiving radiology or radiation oncology services, there must be close collaboration between physical scientists, tumor biologists, and clinicians. The most important role of the clinician is to design and conduct clinical trials that assess the safety and efficacy of a newly developed nanomaterial. Fulfillment of this role requires not only clinical trials expertise, but also familiarity with the physical and chemical characteristics of the nanomaterial being tested and with the results of preclinical studies. Clinician input can also be critical in the conception of a nanotechnology study, in obtaining funding for such a study, in preclinical studies, especially those that involve animal imaging, and in dealing with regulatory agencies. To participate fully in the entire bench ? bedside process, radiologists and radiation oncologists must have a basic understanding of nanotechnology concepts and methodologies, a familiarity with nanotechology safety and regulatory issues, and an excellent grasp of the principles and practices of tumor biology. Furthermore, they need to be well-versed in the design and conduct of clinical trials, be familiar with small animal imaging, and be able to write research grants, IND applications, and manuscripts. There are presently no formal mechanisms by which clinicians in these specialties can acquire these skills and knowledge. To address these needs, Northwestern University, in conjunction with the University of Chicago, is proposing this education and career development program. The program will consist of formal coursework, supplementary educational experiences, participation in a laboratory-based cancer nanotechnology project, and participation in a cancer-related radiology or radiation oncology clinical study. Trainees will have the option of completing the requirements for a Master of Science in Clinical Investigation (MSCI). Program management will consist of the program director, Dr. Gayle Woloschak, four additional faculty members who will oversee various trainee activities, an advisory committee, and a program administrator. While the program is targeted to MDs who have just completed a residency in radiology or radiation oncology, it will also be open to practicing clinicians in these specialties. The program will operate under the auspices of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, with strong support from the Depts. of Radiology and of Radiation Oncology at Northwestern University and from the Depts. of Radiology and of Radiation & Cellular Oncology at the University of Chicago. The program will have strong links to Northwestern's Center for Cancer Nanotechnology Excellence.

描述（由申请人提供）：这是建立 R25T 癌症教育和职业发展计划“癌症纳米技术成像和放射治疗”提案的第二次修订。放射学和放射肿瘤学是临床专业，大量用于癌症诊断和治疗，并且可能会因纳米技术的进步而发生革命性的变化。为了使纳米技术研究的成果造福于接受放射学或放射肿瘤学服务的患者，物理科学家、肿瘤生物学家和临床医生之间必须密切合作。临床医生最重要的作用是设计和进行临床试验，评估新开发的纳米材料的安全性和有效性。履行这一职责不仅需要临床试验专业知识，还需要熟悉所测试的纳米材料的物理和化学特性以及临床前研究的结果。临床医生的投入对于纳米技术研究的构思、为此类研究获得资金、临床前研究（尤其是涉及动物成像的研究）以及与监管机构打交道也至关重要。整个替补席充分参与？在临床过程中，放射科医生和放射肿瘤学家必须对纳米技术的概念和方法有基本的了解，熟悉纳米技术的安全和监管问题，并很好地掌握肿瘤生物学的原理和实践。此外，他们需要精通临床试验的设计和进行，熟悉小动物成像，并能够撰写研究资助、IND申请和手稿。目前尚无正式机制可供这些专业的临床医生获取这些技能和知识。为了满足这些需求，西北大学与芝加哥大学联合提出了这一教育和职业发展计划。该计划将包括正式课程、补充教育经验、参与基于实验室的癌症纳米技术项目以及参与与癌症相关的放射学或放射肿瘤学临床研究。学员可以选择完成临床研究理学硕士（MSCI）的要求。项目管理人员将包括项目总监盖尔·沃洛沙克 (Gayle Woloschak) 博士、另外四名负责监督各种实习生活动的教员、一个咨询委员会和一名项目管理员。虽然该计划针对的是刚刚完成放射学或放射肿瘤学住院医师培训的医学博士，但它也将向这些专业的执业临床医生开放。该项目将在西北大学罗伯特·H·卢里综合癌症中心的赞助下运作，并得到各部门的大力支持。西北大学放射学和放射肿瘤学系以及各系。芝加哥大学放射学系和放射与细胞肿瘤学系。该计划将与西北大学癌症纳米技术卓越中心建立密切联系。

项目成果

期刊论文数量（30）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Percutaneous in utero thoracoamniotic shunt creation for fetal thoracic abnormalities leading to nonimmune hydrops.

经皮子宫内胸腔羊膜分流术治疗胎儿胸部异常导致非免疫性积水。

DOI：
10.1016/j.jvir.2014.02.009
发表时间：
2014
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
0
作者：
White,SarahB;Tutton,SeanM;Rilling,WilliamS;Kuhlmann,RandallS;Peterson,ErikaL;Wigton,ThomasR;Ames,MaryB
通讯作者：
Ames,MaryB

Volume-based pulsed-dose-rate brachytherapy boosting concurrent chemoradiation as a definitive treatment modality in cervical cancer.

基于容量的脉冲剂量率近距离放射治疗促进同步放化疗成为宫颈癌的明确治疗方式。

DOI：
10.1016/j.brachy.2013.10.010
发表时间：
2014
期刊：
Brachytherapy
影响因子：
1.9
作者：
Refaat,Tamer;Nickers,Philippe;Lartigau,Eric
通讯作者：
Lartigau,Eric

The Predictive Value of Pretreatment 18-F-FDG-PET-CT in Locally Advanced Nasopharyngeal Cancer Patients Treated Definitively with Induction Chemotherapy Followed by Concurrent Chemo-Radiotherapy.

预处理 18-F-FDG-PET-CT 对接受诱导化疗并发放化疗的局部晚期鼻咽癌患者的预测价值。

DOI：
10.4172/2155-9619.1000166
发表时间：
2014
期刊：
Journal of nuclear medicine & radiation therapy
影响因子：
0
作者：
Zaghloul,HalaA;Khedr,GehanA;Rostom,Yousri;Refaat,Tamer
通讯作者：
Refaat,Tamer

Hyperthermia and radiation therapy for locally advanced or recurrent breast cancer.

DOI：
10.1016/j.breast.2015.03.008
发表时间：
2015-08
期刊：
Breast (Edinburgh, Scotland)
影响因子：
0
作者：
Refaat T;Sachdev S;Sathiaseelan V;Helenowski I;Abdelmoneim S;Pierce MC;Woloschak G;Small W Jr;Mittal B;Kiel KD
通讯作者：
Kiel KD

Biofunctionalized Hybrid Magnetic Gold Nanoparticles as Catalysts for Photothermal Ablation of Colorectal Liver Metastases.

DOI：
10.1148/radiol.2017161497
发表时间：
2017-07
期刊：
Radiology
影响因子：
19.7
作者：
S. White;Dong‐Hyun Kim;Yang Guo;Weiguo Li;Yihe Yang;Jeane Chen;V. Gogineni;A. Larson
通讯作者：
S. White;Dong‐Hyun Kim;Yang Guo;Weiguo Li;Yihe Yang;Jeane Chen;V. Gogineni;A. Larson