Radiation induced cancer risk reduction as a function of dose protraction: interspecies comparison

辐射诱发的癌症风险降低作为剂量延长的函数：种间比较

基本信息

批准号：
9980304
负责人：
GAYLE E. WOLOSCHAK
金额：
$ 33.58万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-16 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9980304
关键词：
Acute Age Animal Model Animals Archives Biological Biology Canis familiaris Chemicals Communities Data Data Set Databases Development Diagnostic Procedure Dose Dose-Rate Effectiveness Environmental Exposure European Evaluation Evaluation Studies Exposure to External Beam Radiation Therapy Factor Analysis Future Gender Government Guidelines Health Human Incidence International International Agencies Ionizing radiation Knowledge Laboratories Letters Life Light Literature Malignant Neoplasms Medical Meta-Analysis Modeling Mus Occupational Organ Organism Policies Population Publications Publishing Radiation Radiation Dose Unit Radiation Protection Radiation exposure Radiation-Induced Cancer Radioisotopes Radiology Specialty Rat-1 Rattus Recommendation Regulation Reporting Research Risk Risk Reduction Roentgen Rays Route Sampling Science Source Statistical Data Interpretation Support Groups Time United Nations United States National Academy of Sciences United States National Institutes of Health Update Value of Life Whole Organism Work X-Ray Computed Tomography age related animal data base cancer risk carcinogenesis computerized tools falls human data improved insight interest novel tumorigenic web site

项目摘要

Ionizing radiation (IR) causes damage to living organisms. The health effects of IR for different total doses and dose rates at which IR was delivered have to be defined by statistical analyses based on whole organism endpoints such as an increase in the risk for development of cancer or an increased risk of life shortening. The factor by which a total dose could be increased, if protracted, for the same final biological effect, is known as dose and dose-rate effectiveness factor (DDREF). The cumulative protracted radiation received by the entire population of USA is very large and falls under regulatory policies that are government defined. These policies rely on the work of national and international agencies evaluating potential dangers of IR using the DDREF value as one of the key input factors for consideration of protracted IR exposures. Ultimately, government regulated limits for occupational and public IR exposures (mostly protracted) and recommendations for X-ray based medical diagnostic procedures (mostly low total doses) all depend on currently accepted DDREF value. Using computational tools and animal data on acute and protracted exposures we found that the DDREF estimate used at this time is inappropriate (Haley et al. 2015) but that dose-rate effectiveness factor (DREF) can be evaluated using extensive animal data. In this project we propose to use interspecies comparisons to refine (1) external beam DREF values and (2) radionuclide dose/quality/route of administration dose rate effectiveness factors (DREF) for specific types of radiation induced cancers (and life shortening from internal emitters). This is especially important in light of the fact that several international bodies are looking to change values for DDREF– a letter from ICRP sent specifically to our group supporting the importance of this work is attached to the application.

电离辐射（IR）会损害生物体。 IR对不同总剂量和运送IR的剂量率必须通过基于整个生物体的统计分析来定义终点，例如增加癌症的风险或增加寿命缩短风险等终点。这如果保护相同的最终生物学效应，则可以通过保护总剂量的因素被称为剂量和剂量率有效性因子（DDREF）。全部收到的累积保护辐射美国的人口非常大，属于政府定义的监管政策。这些政策依靠使用DDREF评估IR的潜在危险的国家和国际机构的工作价值是考虑受保护的IR暴露的关键输入因素之一。最终，政府对职业和公共红外暴露的规范限制（主要是旷日持久）和X射线的建议基于医学诊断程序（主要是总剂量）都取决于当前接受的DDREF值。使用有关急性和保护暴露的计算工具和动物数据，我们发现DDREF 目前使用的估计值是不合适的（Haley等，2015），但该剂量率有效性因子（DREF）可以使用广泛的动物数据进行评估。在这个项目中，我们建议使用种间比较精炼（1）外梁DREF值和（2）放射性剂量/质量/给药量速率有效性因素（DREF）用于特定类型的辐射引起的癌症（以及内部寿命缩短发射器）。鉴于几个国际机构正在寻求改变这一事实，这一点尤其重要 DDREF的值 - ICRP的一封信，专门发送给我们的小组，支持这项工作的重要性是附在应用程序上。