Advanced Development of TIES-Enhancing Access to Tissue for Cancer Research

TIES 的先进发展——增强癌症研究组织的获取

基本信息

批准号：
8606937
负责人：
Rebecca S Jacobson
金额：
$ 68.7万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-25 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8606937
关键词：
Advanced Development Agreement Archives Authorization documentation Automobile Driving Biological Assay Biological Markers Biological Models Cancer Center Cancer Patient Cancer Research Network Collaborations Computer software Consent Data Development Disease Feedback Formalin Grant Health Sciences Human Image Imagery Individual Informatics Institution Institutional Review Boards Interview Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of ovary Malignant neoplasm of urinary bladder Management Audit Measures Medicine Methods Modeling Molecular Molecular Analysis Natural Language Processing Paraffin Paraffin Embedding Patient Care Patients Pennsylvania Phenotype Pilot Projects Policies Principal Investigator Privacy Process Production Productivity Recruitment Activity Registries Research Research Personnel Resources Reverse Transcriptase Polymerase Chain Reaction Roswell Park Cancer Institute Security Services Site Slide Specimen Speed Structure Surveys System Time Tissue Microarray Tissues Translational Research Trust Universities Validation Work anticancer research computerized data processing design electronic data exome genome sequencing human tissue improved malignant breast neoplasm melanoma member public health relevance repository software systems tumor usability virtual

项目摘要

DESCRIPTION (provided by applicant): Archived human tissues are an essential resource for translational research. Formalin-fixed, paraffin-embedded (FFPE) tissues from cancer patients are used in a wide range of assays, including RT-PCR, SNP profiling, multiplex biomarkers, imaging biomarkers, targeted exome, whole exome, and whole genome sequencing. Remainder FFPE tissues generated during patient care are 'retrospective'; use of these tissues under specific conditions does not require consent. For personalized medicine researchers, these specimens are vital resources enabling biomarker validation, detailed molecular analysis, and systems modeling before application is made to individual patients. But access to these human tissues is often a rate limiting factor in cancer research. We propose advanced development of the TIES software to (1) increase institutional capacity for using FFPE to support molecular characterization of human tumors, (2) increase access to tissues within cancer centers, and (3) improve the ability to share tissues and associated phenotype data among cancer centers.

描述（由申请人提供）：存档的人体组织是转化研究的重要资源。来自癌症患者的福尔马林固定石蜡包埋 (FFPE) 组织可用于多种检测，包括 RT-PCR、SNP 分析、多重生物标志物、成像生物标志物、靶向外显子组、全外显子组和全基因组测序。在患者护理过程中产生的剩余 FFPE 组织具有“回顾性”；在特定条件下使用这些组织不需要征得同意。对于个性化医学研究人员来说，这些标本是重要的资源，可以在应用于个体患者之前进行生物标志物验证、详细的分子分析和系统建模。但获取这些人体组织往往是癌症研究的一个限制因素。我们建议进一步开发 TIES 软件，以 (1) 提高使用 FFPE 支持人类肿瘤分子表征的机构能力，(2) 增加癌症中心内组织的获取，以及 (3) 提高共享组织和相关表型的能力癌症中心之间的数据。