Syphilis social epidemiology in the People's Republic of China

中华人民共和国梅毒社会流行病学

• 批准号: 8531366
• 负责人: Joseph David Tucker
• 金额: $ 13.18万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531366
• 关键词: Anthropology; Area; Attitude; Behavior; Behavioral; Biosocial; Caring; Characteristics; China; Chinese People; Cities; Clinic; Communicable Diseases; Communities; Complex; Congenital Syphilis; Disclosure; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Epidemic; Epidemiology; Faculty; Far East; Foundations; Fright; General Hospitals; Goals; HIV; HIV Infections; Health Priorities; Health behavior; Hour; Human immunodeficiency virus test; Income; Individual; Infection; Knowledge; Link; Low income; Massachusetts; Mentors; Methods; Modeling; Myron; Patients; Physicians; Plague; Positioning Attribute; Prevention; Principal Investigator; Probability; Public Health; Qualitative Methods; Qualitative Research; Research; Research Methodology; Research Personnel; Research Training; Risk; Services; Sexual Health; Sexually Transmitted Diseases; Shapes; Site; Social Sciences; Sociology; Syphilis; Syphilis Serodiagnosis; System; Taiwan; Testing; Textiles; Training; Tuberculosis; Twin Multiple Birth; United States National Institutes of Health; Work; care systems; clinical epidemiology; effective intervention; experience; global health; high risk; improved; international center; novel; programs; public health relevance; response; scale up; screening; skills; social; social stigma; transmission process; uptake

DESCRIPTION (provided by applicant): Sexually transmitted infection (STI) patients co-infected with syphilis and HIV have some of the highest HIV transmission probabilities, yet many STI patients often never receive screening for either of these frequently asymptomatic STIs. This KOI application details a four year plan focused on implementing integrated syphilis/HIV services in South China, a region characterized by hyper endemic syphilis transmission and increasing sexual HIV transmission. Linking clinical epidemiology and social science methods, the research and training plan will be mentored by Dr. Myron S. Cohen (Infectious Diseases), Dr. Xiang-Sheng Chen (Epidemiology), and Dr. Martin K. Whyte (Sociology). The training component will include advanced coursework on clinical epidemiology, anthropology, and Mandarin Chinese to complete a Masters in Regional Studies East Asia (MRSEA) at Harvard. As an Infectious Disease Fellow at the Massachusetts General Hospital, I completed a preliminary study that found HIV to be independently associated with syphilis infection at STI clinics in South China. Syphilis test acceptance at STI clinics was greater than 90%, but HIV testing acceptance was poor. Responding to South China's expanding syphilis epidemic, the WHO has launched a pilot program in two cities providing free rapid syphilis testing at select STI clinics, introducing a special opportunity for parallel HIV operational research. Transitioning to the Massachusetts General Hospital faculty with my mentor's support, I will focus on the following three specific aims: 1) To analyze STI patient characteristics that correlate to accepting HIV testing at STI clinics; 2) To describe the social and cultural context of HIV testing STI patients using qualitative methods; 3) To assess STI physician characteristics that correlate to offering HIV testing. The proposed training and research program will provide a foundation to understand the complex biosocial fabric of rapidly evolving sexual health behaviors in China, uniquely positioning me as a junior investigator to implement novel behavioral responses to the twin epidemics of syphilis and HIV in China.

描述（由申请人提供）：与梅毒和HIV共同感染的性传播感染（STI）患者具有最高的HIV传播概率，但是许多STI患者通常从未接受过这些经常无症状的性传播感染的筛查。该锦鲤应用程序详细介绍了一项四年计划，重点是在中国南部实施梅毒/艾滋病毒综合服务，该地区以高流行的梅毒传播和增加性HIV传播为特征。将临床流行病学和社会科学方法联系起来，研究和培训计划将由Myron S. Cohen博士（传染病），Xiang-Sheng Chen博士（流行病学）和Martin K. Whyte博士（社会学）指导。该培训组成部分将包括有关临床流行病学，人类学和普通话的高级课程，以完成哈佛大学区域研究的硕士学位。作为马萨诸塞州综合医院的传染病研究员，我完成了一项初步研究，发现HIV与中国南部STI诊所的梅毒感染独立相关。 STI诊所的梅毒测试接受度大于90％，但HIV检测接受率很差。为了回应中国南部不断扩大的梅毒流行病，该世卫组织在两个城市启动了一项试点计划，该计划在精选的STI诊所提供了免费的快速梅毒测试，为平行的HIV运营研究提供了特殊的机会。通过导师的支持过渡到马萨诸塞州综合医院教职员工，我将重点介绍以下三个特定目标：1）分析与在STI诊所接受HIV测试相关的STI患者特征； 2）使用定性方法来描述HIV测试患者的艾滋病毒测试患者的社会和文化背景； 3）评估与提供HIV测试相关的STI医师特征。拟议的培训和研究计划将为了解中国快速发展的性健康行为的复杂生物社会结构提供基础，使我成为初级研究者，以实施对中国梅毒和艾滋病毒双重流行病的新型行为反应。

项目成果

Mainstreaming HIV services for men who have sex with men: the role of general practitioners.

将针对男男性行为者的艾滋病毒服务纳入主流：全科医生的作用。

• DOI: 10.1136/sextrans-2012-050626
• 发表时间: 2012
• 期刊: Sexually transmitted infections
• 影响因子: 3.6
• 作者: Wong,WilliamCW;Kidd,MichaelRichard;Tucker,JosephD
• 通讯作者: Tucker,JosephD

Falling down and following up.

• DOI: 10.1016/s0140-6736(12)60645-x
• 发表时间: 2012-09-08
• 期刊: LANCET
• 影响因子: 168.9
• 作者: Wang, Charles;Cai, Wei-Ping;Tucker, Joseph D.;Li, Ling-Hua;Hu, Feng-Yu
• 通讯作者: Hu, Feng-Yu

Methadone maintenance treatment participant retention and behavioural effectiveness in China: a systematic review and meta-analysis.

中国美沙酮维持治疗参与者的保留率和行为有效性：系统回顾和荟萃分析

• DOI: 10.1371/journal.pone.0068906
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Zhang L;Chow EP;Zhuang X;Liang Y;Wang Y;Tang C;Ling L;Tucker JD;Wilson DP
• 通讯作者: Wilson DP

Unsafe Sex and STI Prevalence Among HIV-Infected Adults in Guangzhou, China: Opportunities to Deamplify Sexual HIV Transmission.

• DOI: 10.1007/s10461-012-0322-y
• 发表时间: 2013-03
• 期刊: AIDS AND BEHAVIOR
• 影响因子: 4.4
• 作者: Wang, Xiao B.;Tucker, Joseph D.;Yang, Ligang;Zheng, Heping;Zhang, Fujie;Cohen, Myron S.;Yang, Bin;Cai, Weiping
• 通讯作者: Cai, Weiping

Health Care Experiences and Perceived Barriers to Health Care Access: A Qualitative Study Among African Migrants in Guangzhou, Guangdong Province, China.

• DOI: 10.1007/s10903-014-0114-8
• 发表时间: 2015-10
• 期刊: JOURNAL OF IMMIGRANT AND MINORITY HEALTH
• 影响因子: 1.9
• 作者: Lin, Lavinia;Brown, Katherine B.;Yu, Fan;Yang, Jingqi;Wang, Jason;Schrock, Joshua M.;Bodomo, Adams B.;Yang, Ligang;Yang, Bin;Nehl, Eric J.;Tucker, Joseph D.;Wong, Frank Y.
• 通讯作者: Wong, Frank Y.