Behavioral Regulation and Real-Time Reinforcement in Alcohol Dependence

酒精依赖的行为调节和实时强化

• 批准号: 8728697
• 负责人: Eric D Claus
• 金额: $ 19.64万
• 依托单位: THE MIND RESEARCH NETWORK
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8728697
• 关键词: Address; Affect; Alcohol dependence; Alcohols; Anterior; Behavior; Behavior Control; Behavioral; Brain; Brain region; Complex; Corpus striatum structure; Costs and Benefits; Cues; Data; Decision Making; Dorsal; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Individual; Inferior frontal gyrus; Insula of Reil; Investigation; Knowledge; Lateral; Neurocognitive; Parietal Lobe; Participant; Pattern; Prefrontal Cortex; Process; Psychological reinforcement; Regulation; Research; Research Personnel; Rewards; Risk; Risk Factors; Specific qualifier value; Staging; Testing; Time; Treatment outcome; Ventral Striatum; Water; Work; alcohol craving; alcohol cue; alcohol response; alcohol reward; alcohol use disorder; cingulate cortex; cognitive control; cue reactivity; executive function; experience; human data; neural circuit; neurobiological mechanism; neuroimaging; neuromechanism; public health relevance; reinforcer; relating to nervous system; response; social

DESCRIPTION (provided by applicant): Behavioral dysregulation is a risk factor for alcohol dependence and likely contributes to failed treatment attempts after the onset of alcohol dependence. Regulation over behavior is a complex process that relies on several functional circuits within the brain that are used to weigh costs and benefits of decisions. The degree to which neural circuits involved in behavioral regulation are affected in alcohol dependence remain largely unknown. To address this dearth of knowledge the proposed study aims to 1) integrate real-time tastant delivery with tasks known to engage regions important for alcohol dependence such as the ventral striatum, anterior cingulate cortex, and inferior frontal gyrus and 2) determine how functional connectivity patterns differ in alcohol dependent individuals compared to social drinkers, in order to determine the mechanisms that underlie automatic and controlled responses to cues that predict alcohol. Alcohol dependent and social drinkers will complete neurocognitive tasks that assess reward sensitivity while undergoing functional magnetic resonance imaging (fMRI) to determine those brain regions that are affected in alcohol dependence, and to better understand how functional connectivity patterns may differ in alcohol dependent individuals.

描述（由申请人提供）：行为失调是酒精依赖性的危险因素，并且可能导致酒精依赖发作后的治疗尝试失败。对行为的监管是一个复杂的过程，它依靠大脑中用于权衡决策成本和收益的大脑中的几个功能电路。酒精依赖性影响行为调节的神经回路的程度仍然很大未知。为了解决这一知识的缺乏，拟议的研究的目的是1）将实时味道的交付与已知与酒精依赖的任务相结合，例如腹侧纹状体，前扣带回皮层和下腹部回旋和额叶的下层和2）确定功能连通性在与酒精相关的人与社交饮酒的方式相比，以确定与酒精相比的机制和对不起的人的饮酒方式，并确定了型号的饮酒方式。依赖酒精和社交饮酒者将完成神经认知任务，以评估奖励灵敏度，同时进行功能性磁共振成像（fMRI），以确定那些在酒精依赖性影响的大脑区域，并更好地了解依赖酒精的人的功能连通性模式如何有所不同。