Frontiers of Structural Biology

结构生物学前沿

• 批准号: 8629641
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8629641
• 关键词: Address; Area; Binding; Bioinformatics; Biological; Biological Models; Biological Phenomena; Biology; Cells; Cellular biology; Collaborations; Communities; Complex; Data; Databases; Deposition; Discipline; Drug Design; Drug Targeting; Education; Electron Microscopy; Emerging Technologies; Fostering; Funding; Funding Mechanisms; Future; G-Protein-Coupled Receptors; Genes; Goals; Image; Immunology; Individual; International; Investments; Knowledge; Membrane Proteins; Methods; National Institute of General Medical Sciences; Outcome; Paint; Physiology; Protein Structure Initiative; Proteins; Records; Research; Research Personnel; Resolution; Resources; Roentgen Rays; Scientist; Seeds; Structural Biologist; Structure; Structure-Activity Relationship; Students; System; Techniques; Technology; Textbooks; Utah; Visual; base; biophysical techniques; drug discovery; frontier; innovation; insight; interest; meetings; model design; novel; outreach; programs; public health relevance; repository; restraint; structural biology; structural genomics; symposium; technology development; ward

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Frontiers of Structural Biology, organized by Andrew B. Ward and Wayne A. Hendrickson. The meeting will be held in Snowbird, Utah from March 30 - April 4, 2014. Direct observation of biological phenomena on a structural level provides a basis for understanding and manipulating molecular interactions within a cell and enabling endeavors such as structure based drug design. The field of structural biology now operates on a scale from atoms to cells and the most exciting research is being conducted at the interface of different technologies. Thus, it is important that practitioners of the various structural biology techniques come together and discuss a more holistic view of the field. Therefore, the goals of this meeting are to connect leaders in the structural biology field and to evaluate novel methods and technologies. Importantly, the meeting will highlight complex cell biological insights made by pioneering structural efforts (across multiple biophysical disciplines) and contributions made by large-scale, high throughput efforts. Additionally, because of the large amount of structural information that is becoming available (and will continue to do so) the meeting will also highlight innovations made in areas of bioinformatics and modeling/design that have begun to harness the increasing structural information. Because this meeting brings together a diverse group of structural biologists that employ a variety of experimental techniques we aim to support the dissemination of cutting edge advances and promote interaction among the vibrant international structural biology community. Opportunities for interdisciplinary interactions will also be significantly enhanced by the concurrent meeting on G Protein-Coupled Receptors: Structural Dynamics and Functional Implications, which will share opening and closing keynote addresses and a plenary session with this meeting.

描述（由申请人提供）：请求支持由Andrew B. Ward和Wayne A. Hendrickson组织的Keystone研讨会会议，标题为“结构生物学的前沿”。该会议将于2014年3月30日至4月4日在犹他州雪鸟举行。在结构层面上直接观察生物学现象为理解和操纵细胞内的分子相互作用提供了基础，并能够促进基于结构的药物设计等努力。现在的结构生物学领域现在从原子到细胞的规模上运行，最令人兴奋的研究正在不同技术的界面进行。因此，重要的是，各种结构生物学技术的从业者聚集在一起 并讨论对该领域的更全面的看法。因此，这次会议的目标是将结构生物学领域的领导者联系起来，并评估新颖的方法和技术。重要的是，这次会议将强调通过开创性的结构性努力（跨多个生物物理学科）和大规模的贡献，大规模的结构性努力（跨多个生物物理学科）提供的复杂细胞生物学见解 高通量努力。此外，由于大量的结构信息已成为可用的（并将继续这样做），这次会议还将重点介绍在生物信息学和建模/设计领域的创新，这些创新已开始利用日益增长的结构信息。因为这次会议汇集了一组采用各种实验技术的各种结构生物学家，我们旨在支持尖端进步的传播，并促进充满活力的国际结构生物学社区之间的互动。关于G蛋白偶联受体的并发会议：结构动力和功能含义，跨学科相互作用的机会也将显着增强，它们将共享开放和关闭的主题演讲，并与本次会议进行全体会议。