MR Brain Diffusion Tensor Imaging in Schizophrenia

精神分裂症的 MR 脑扩散张量成像

• 批准号: 8586852
• 负责人: Martha E. Shenton
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2014-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8586852
• 关键词: Address; Affect; Age; Anisotropy; Anterior; Area; Astrocytes; Attention; Auditory; Auditory Hallucination; Auditory area; Autopsy; Award; Behavior; Bibliography; Biological; Biological Markers; Brain; Brain Diseases; Brain region; Categories; Cell Nucleus; Cells; Chronic; Chronic Schizophrenia; Clinical; Code; Cognition; Cognitive; Communication; Computers; Control Groups; Controlled Study; Corpus Callosum; Data; Delusions; Detection; Development; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Dorsal; Ear; Emotional; Emotions; Episodic memory; Event-Related Potentials; Evolution; Exhibits; Fiber; Functional disorder; Funding; Gender; General Population; Genes; Genetic; Goals; Grant; Hallucinations; Hand; Handedness; Health; Health Care Costs; Hospitalization; Image; Imaging Device; Imaging Techniques; Imaging technology; Immigration; Individual; Inferior; Inpatients; Internal Capsule; Investigation; Joystick; Lead; Left; Lesion; Letters; Light; Limb structure; Link; Literature; Lobule; Location; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Matched Group; Measures; Medial; Medical; Memory; Metabolism; Mission; Modeling; Monitor; Motor; Movement; Myelin; Myelin Sheath; N-Methylaspartate; Nature; Neurobehavioral Manifestations; Neuroglia; Neurologic; Neurons; Oligodendroglia; Onset of illness; Optics; Outpatients; Paranoia; Parietal; Participant; Patients; Performance; Pharmaceutical Preparations; Plague; Play; Prefrontal Cortex; Process; Progress Reports; Proteins; Psyche structure; Publications; Publishing; Radiation; Recording of previous events; Regulation; Relative (related person); Reporting; Research Design; Role; Sampling; Sampling Studies; Scanning; Schizophrenia; Secondary to; Semantics; Sensory; Severities; Short-Term Memory; Signal Transduction; Site; Socioeconomic Status; Somatosensory Cortex; Speech; Staging; Stimulus; Structure; Study Subject; Superior temporal gyrus; Susceptibility Gene; Symptoms; Synapses; System; Temporal Lobe; Testing; Thalamic structure; Time; Trail Making Test; Verbal Learning; Visual attention; Visual evoked cortical potential; Visuospatial; Water Movements; Work; base; cingulate cortex; cognitive function; cost; experience; follow-up; foster care; frontal lobe; gray matter; human subject; improved; in vivo; interest; interhemispheric transfer; language processing; longitudinal design; memory retrieval; morphometry; neural circuit; neuroimaging; neuropathology; neuropsychological; neurotransmission; new technology; novel; performance tests; physical property; processing speed; programs; progression marker; public health relevance; relating to nervous system; semantic processing; social cognition; spinal tract; synaptic function; tool; visual information; visual memory; white matter; white matter change

DESCRIPTION (provided by applicant): The long-term objective of this proposal is to understand the nature of brain abnormalities in schizophrenia by applying in vivo neuroimaging tools from the rapidly developing field of neuroimaging. The short-term objective is to evaluate white matter abnormalities using Magnetic Resonance (MR) Diffusion Tensor Imaging (DTI), a relatively new neuroimaging tool that reveals the physical properties of white matter. Of particular note, this new imaging tool is the only in vivo tool available to evaluate white matter fiber bundle abnormalities in schizophrenia, and, while plagued by problems expected in a new field of inquiry, it is still the most promising and powerful tool available to evaluate white matter alterations in schizophrenia. This imaging technique will be used to investigate white matter abnormalities in fronto-temporal white matter connections, interhemispheric white matter connections, thalamo-frontal fiber tracts, and frontal-parietal white matter connections. The subject sample will be right-handed patients with schizophrenia (both chronic and first episode) and age, gender, handedness, and parental socioeconomic status group matched controls. The study sample will be comprised of 50 chronic patients,110 first episode patients, and 160 controls studied at baseline over the 5 year grant period, and 50 first episode and 50 controls studied again at follow up one year later. MR DTI region of interest and tractography measures will be used to quantify anisotropic diffusion (degree of directionality of water movement, measured as fractional anisotropy) and diffusivity (average diffusion in all directions) in the aforementioned fiber bundles. Longitudinal changes will also be evaluated one year later in first episode patients and controls in order to determine progressive changes in white matter over this time period in first episode patients compared with controls. Specific predictions are made with respect to cognitive and DTI abnormalities (e.g., correlations between semantic priming abnormalities and arcuate fasciculus abnormalities). In addition another measure of white matter health and integrity, the interhemispheric transfer time task (IHTT), will be included in a visual evoked potential study, where it is predicted that IHTT efficiency will be compromised in schizophrenia. It is also predicted that longer IHTT, and decreased asymmetry, will be correlated with DTI measures in posterior portions of the corpus callosum, the largest white matter tract in the brain, which, in turn, will be correlated with measures of speed of processing. A longitudinal design is also a part of the IHTT measures, i.e., first episode patients and controls will be evaluated one year later. The investigation of MR DTI in schizophrenia will lead to a further understanding of white matter fiber tract abnormalities in this disorder, which will add a key link to understanding the neuropathology of schizophrenia, and ultimately to better and more rational treatment. PUBLIC HEALTH RELEVANCE: Schizophrenia is a devastating disorder that affects close to 1% of the general population and 40% of all VA mental healthcare costs (http://www.va.gov). Understanding this disorder is thus critical to the VA mission. Magnetic Resonance (MR) Diffusion Tensor Imaging (DTI) will be used to investigate white matter (WM) brain abnormalities in schizophrenia. Heretofore, conventional MR findings reported gray matter abnormalities, but few studies reported WM abnormalities. With the advent of DTI, WM tracts important to schizophrenia can now be investigated. DTI images will be acquired from chronic and first-episode patients, as well as controls. A measure of processing speed will also be included and relevant cognitive and symptom measures will be evaluated to determine associations among WM, cognitive abnormalities, clinical symptoms, and processing speed. This proposal will lead to new findings regarding WM abnormalities and cognitive and clinical correlates, which, in turn, will ultimately lead to better and more rationale treatment of this devastating disorder.

描述（由申请人提供）： 该提案的长期目标是通过应用快速发展的神经影像领域的体内神经影像学工具来了解精神分裂症中脑异常的性质。短期目标是使用磁共振（MR）扩散张量成像（DTI）评估白质异常，这是一种相对较新的神经影像学工具，揭示了白质的物理特性。尤其值得注意的是，这种新成像工具是唯一可用于评估精神分裂症中白质纤维束异常的体内工具，尽管在新的询问领域期望的问题困扰着，但它仍然是最有前途且功能强大的工具，可用于评估精神分裂症的白质改变。这种成像技术将用于研究额颞质的白质连接，半球白质连接，丘脑额叶纤维纤维区和正面白质连接的白质异常。该受试者样本将是精神分裂症（慢性和第一事件）以及年龄，性别，惯性和父母社会经济状况组匹配控制的右撇子患者。该研究样本将由50名慢性患者，110例第一集患者和160个对照组组成，该对照在5年的赠款期间研究了，一年后的随访中再次研究了50个第一集和50个对照。 MR DTI感兴趣的区域和拖拉术措施将用于定量各向异性扩散（水运动的方向性，以分数各向异性的测量）和上述纤维浮雕中的扩散率（所有方向平均扩散）。一年后的第一事件患者和对照组还将评估纵向变化，以确定与对照组相比，第一集患者的这段时间内白质的进行性变化。关于认知和DTI异常（例如，语义启动异常与弓形筋膜异常之间的相关性）的具体预测。此外，另一种衡量白质健康和完整性的衡量标准还将包括在视觉诱发的潜在研究中，将包括iHtt效率在精神分裂症中受到损害。还可以预测，较长的IHTT和降低的不对称性将与Callosum后部的DTI度量相关，call体的后部是大脑中最大的白质区，这又将与处理速度的度量相关。纵向设计也是IHTT措施的一部分，即，一年后将评估第一集的患者和对照组。对精神分裂症中DTI先生的研究将导致对这种疾病中的白质纤维道异常的进一步理解，这将为理解精神分裂症的神经病理学增添关键联系，并最终以更好，更理性的治疗。 公共卫生相关性： 精神分裂症是一种毁灭性疾病，影响近1％的普通人群和所有VA心理保健成本的40％（http://www.va.gov）。因此，了解这种疾病对VA任务至关重要。磁共振（MR）扩散张量成像（DTI）将用于研究精神分裂症中的白质（WM）脑异常。迄今为止，常规的MR调查结果报告了灰质异常，但很少有研究报告WM异常。随着DTI的出现，现在可以研究对精神分裂症重要的WM区。 DTI图像将从慢性和第一集患者以及对照组中获取。还将包括一项处理速度的度量，并将评估相关的认知和症状措施，以确定WM之间的关联，认知异常，临床症状和加工速度。该提案将导致有关WM异常以及认知和临床相关性的新发现，这反过来又将导致对这种毁灭性疾病的更好，更多的理由治疗。