CORE 3: IMAGING

核心 3：成像

• 批准号: 8136032
• 负责人: Martha E. Shenton
• 金额: $ 26.29万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136032
• 关键词: Affect; Arts; Brain; Clinical; Cognitive; Disease; General Population; Genetic; Health; Hormonal; Image; Imaging Techniques; Lead; Post Technic; Prevention strategy; Process; Research Personnel; Role; Schizophrenia; United States; Work; interest; neuroimaging; progression marker; tool

Neuroimaging studies have led to important findings with respect to brain abnormalities in schizophrenia. In fact we know more about schizophrenia in the last two decades than in the prior century, and this is largely due to the advent of new imaging techniques that have lead to an appreciation of the role of brain abnormalities in this disorder. The objective of the Imaging Core is to provide state-of-the-art neuroimaging techniques and post-processing tools to support the work of CIDAR projects and investigators interested in evaluating brain abnormalities in schizophrenia in conjunction with cognitive, clinical, hormonal, and electrophysiological abnormalities, as well as genetic influences, so as to understand better putative markers of progression in schizophrenia. Moreover, understanding what factors are associated with progression in schizophrenia will likely lead to more targeted treatments as well as to prevention strategies for this devastating disorder, which affects close to 1 % of the general population and is thus a major health problem in the United States.

神经影像学研究导致了关于精神分裂症的脑异常的重要发现。在 事实，我们在过去二十年中比上一个世纪更了解精神分裂症，这在很大程度上是 由于新成像技术的出现，这导致了对大脑的作用的欣赏 这种疾病异常。成像核心的目的是提供最新的神经影像学 支持CIDAR项目的工作和对研究人员感兴趣的研究人员的技术和后处理工具 评估精神分裂症中脑异常与认知，临床，荷尔蒙和 电生理异常以及遗传影响，以了解更好的推定标记 精神分裂症的进展。此外，了解哪些因素与进展有关 精神分裂症可能会导致更多针对性的治疗以及预防策略 毁灭性疾病，影响近1％的普通人群，因此是一个主要的健康问题 在美国。