Heathy Bodies, Healthy Minds: Helping Adolescents with PCOS

健康的身体，健康的思想：帮助患有多囊卵巢综合症的青少年

• 批准号: 8519494
• 负责人: Dana L Rofey
• 金额: $ 12.61万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-21 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8519494
• 关键词: 21 year old; Address; Adolescence; Adolescent; Adolescent Medicine; Adult; Affect; Affective; Aftercare; Age; Base of the Brain; Behavior; Behavior Therapy; Behavioral; Biometry; Body mass index; Brain; Calories; Cardiovascular Diseases; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Child; Childhood; Chronic; Chronic Disease; Clinic; Clinical; Clinical Trials Design; Cognitive Therapy; Collection; Complement; Complex; Data; Data Analyses; Development; Diabetes Mellitus; Disease; Eating; Emotional; Emotional Disturbance; Emotions; Endocrine; Endocrinology; Energy Metabolism; Environment; Etiology; Event; Exercise; Exhibits; Family; Female Adolescents; Future; Glucose; Goals; Hormones; Hyperandrogenism; Infertility; Inflammation; Insulin; Insulin Resistance; Interleukin-6; Intervention; Intervention Studies; Journals; Kilogram; Knowledge; Laboratories; Leptin; Licensing; Life; Life Style; Manuals; Measurement; Measures; Medical; Medicine; Menstrual cycle; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Metabolic; Methodology; Mind; Modeling; Monitor; Mood Disorders; Moods; Morbidity - disease rate; Neurobiology; Neurosciences; Obesity; Outcome; Outcome Study; Outcomes Research; Overweight; Participant; Patients; Pattern; Pediatrics; Pharmaceutical Preparations; Physical activity; Physiological; Physiological Processes; Physiology; Polycystic Ovary Syndrome; Population; Positioning Attribute; Process; Psychiatry; Psychologist; Public Health; Questionnaires; Race; Randomized Controlled Trials; Reading; Research; Research Infrastructure; Research Personnel; Research Project Grants; Schedule; Schizophrenia; Schools; Site; Sleep; Sleep disturbances; Social Environment; Solutions; Statistical Models; Symptoms; Syndrome; System; Techniques; Testosterone; Time; Training; Translational Research; Treatment outcome; Universities; Weight; Weight maintenance regimen; Weights and Measures; Woman; Women' s Health; actigraphy; base; body-mind; children' s depression inventory; depressive symptoms; design; deviant; disorder prevention; disturbance in affect; effective intervention; evaluation/testing; experience; ghrelin; improved; innovation; insight; interdisciplinary approach; longitudinal analysis; meetings; mortality; nutrition; obesity in children; physical model; programs; prospective; psychologic; public health relevance; remediation; reproductive; sedentary; shift work; standard of care; statistics; success; symposium; waist circumference

DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award (K23) will enable Dr. Dana Rofey to conduct interdisciplinary, longitudinal intervention research in adolescents with behavioral (obesity, sleep), emotional (depression), and physical (insulin, glucose, ghrelin, leptin, IL-6, and CRP) disturbances. This application will investigate adolescents with Polycystic Ovary Syndrome (PCOS) which will serve as a model physical illness consisting of high rates of obesity, depression, and sleep disturbances. The candidate is a licensed clinical psychologist, specialized in obesity, who also has prior training in a) the etiology, assessment, and treatment of depression; b) experience in the conduct of treatment-outcome research (i.e., manual development, pilot testing, evaluation); c) basic techniques in multivariate statistics; d) an understanding of the interdisciplinary aspects of childhood obesity; and e) clinical trial design and implementation. Dr. Rofey's short-term goals are to pursue training in neurobiological factors related to PCOS with a focus on sleep as a marker of brain activity; endocrine and metabolic aspects of obesity, and statistical modeling for the analysis of longitudinal treatment outcomes. Training will be accomplished via (a) meetings and guided readings with mentors Ronald Dahl MD and Silva Arslanian MD, and an expert team of consultants; (b) formal coursework; (c) attendance at conferences, journal clubs, and research meetings; and (d) supervised hands-on experiences in the collection and analysis of data. The University Of Pittsburgh School Of Medicine will be the primary site of this training, offering a combination of excellence in pediatrics, psychiatry, endocrinology, and biostatistics. Within the infrastructure of the Polycystic Ovary Syndrome Center and The Adolescent Medicine Clinic, the proposed research will include 126, 11-21.-year-old adolescents with PCOS. The study aims to investigate the effects of an enhanced cognitive behavioral therapy on physical (weight, sleep) and emotional (mood) disturbances, as well as to explore the relationship between remediation of symptoms and underlying physiological changes (e.g., insulin, inflammation). The proposed plan incorporates an innovative methodology that bridges objective laboratory measures of weight, emotion, and sleep and more ecologically valid measurements within the adolescents' real-world environment utilizing ecological momentary assessment (EMA). Insights into efficacious interventions for adolescents with complex chronic illness alongside of physical and emotional disturbances will place the applicant in a strong position to conduct translational research for adolescents with obesity. PUBLIC HEALTH RELEVANCE: Complex and interrelated processes in adolescents with obesity make efficacious interventions challenging. This enhanced cognitive behavioral therapy creates a synergistic effect across domains (weight, mood, and sleep) in ways that become increasingly salient during adolescence. This research will lay the groundwork for future interventions targeting important physical, emotional, and behavioral facets.

描述（由申请人提供）：这项受到指导的以患者为导向的研究职业发展奖（K23）将使Dana Rofey博士能够对具有行为（肥胖，睡眠），情感（抑郁症）的青少年进行跨学科的纵向干预研究，并进行纵向干预研究（抑郁症（抑郁症），身体（胰岛素，葡萄糖，葡萄糖，ghrelin，Ghrelin，leptin，leptin，leptin，il-6和CRP）。该应用将调查患有多囊卵巢综合征（PCOS）的青少年，该综合征将用作模型的身体疾病，包括高肥胖，抑郁症和睡眠障碍。候选人是一名有执照的临床心理学家，专门从事肥胖症，他们也先接受了a）抑郁症的病因，评估和治疗； b）进行治疗结果研究的经验（即手动开发，试点测试，评估）； c）多元统计中的基本技术； d）了解儿童肥胖的跨学科方面； E）临床试验设计和实施。 Rofey博士的短期目标是进行与PCOS有关的神经生物学因素的培训，重点是睡眠作为大脑活动的标志。肥胖的内分泌和代谢方面，以及分析纵向治疗结果的统计建模。培训将通过（a）会议和导师Ronald Dahl MD和Silva Arslanian MD以及顾问专家团队来完成； （b）正式课程； （c）参加会议，期刊俱乐部和研究会议； （d）在收集和分析数据中有监督的动手经验。匹兹堡大学医学院将是这项培训的主要地点，它提供了儿科，精神病学，内分泌学和生物统计学方面的卓越成就。在多囊卵巢综合征中心和青少年医学诊所的基础设施中，拟议的研究将包括126、11-21岁的PCOS青少年。该研究旨在研究增强的认知行为疗法对身体（体重，睡眠）和情绪（情绪）障碍的影响，以及探索症状的补救与潜在生理变化（例如胰岛素，炎症）之间的关系。拟议的计划结合了一种创新的方法，该方法可以在青少年的真实世界环境中利用生态瞬时评估（EMA）桥接客观实验室的体重，情感和睡眠的测量以及更有效的测量。对患有复杂慢性疾病的青少年以及身体和情感障碍的有效干预措施的见解将使申请人处于强大的位置，以对肥胖症的青少年进行转化研究。 公共卫生相关性：肥胖症青少年的复杂和相互关联的过程，使干预措施具有挑战性。这种增强的认知行为疗法以在青春期越来越突出的方式跨领域（体重，情绪和睡眠）产生了协同作用。这项研究将为针对重要的身体，情感和行为方面的未来干预措施奠定基础。

项目成果

Parents' Readiness to Change Affects BMI Reduction Outcomes in Adolescents with Polycystic Ovary Syndrome.

父母对改变的准备程度会影响患有多囊卵巢综合症的青少年的体重指数降低结果。

• DOI: 10.1155/2012/298067
• 发表时间: 2012
• 期刊: Journal of obesity
• 影响因子: 3.3
• 作者: Jakubowski,KarenP;Black,JessicaJ;ElNokali,NermeenE;Belendiuk,KatherineA;Hannon,TamaraS;Arslanian,SilvaA;Rofey,DanaL
• 通讯作者: Rofey,DanaL