Role of breast milk in development of neonatal oral tolerance to foods

母乳在新生儿口腔食物耐受性发展中的作用

• 批准号: 8528461
• 负责人: Kirsi Jarvinen-Seppo
• 金额: $ 12.95万
• 依托单位: ALBANY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8528461
• 关键词: Address; Adherence; Allergens; Allergic; Allergic Reaction; Allergy to peanuts; Anaphylaxis; Animal Model; Animals; Antibodies; Antigen Presentation; Antigens; Asthma; Basic Science; Biological; Biological Markers; Biometry; Birth; Breast Feeding; Cattle; Cells; Child; Childhood; Clinical Research; Controlled Clinical Trials; Data; Defect; Development; Diet; Eating; Enhancing Antibodies; Environmental Risk Factor; Exclusion; Experimental Models; Exposure to; Faculty; Family; Food; Food Hypersensitivity; Frequencies; Future; Goals; Guidelines; Health; Human; Human Cell Line; Human Milk; Hypersensitivity; Immune; Immune Tolerance; Immune response; Immunity; Immunobiology; Immunoglobulin A; Immunoglobulin G; Immunoglobulins; Immunology; Infant; Institutes; Intestines; Journals; Knowledge; Lactation; Literature; Microbe; Milk; Milk Hypersensitivity; Modeling; Mothers; Mus; Neonatal; Oral Administration; Outcome; Ovalbumin; Patient Care; Peanuts - dietary; Perinatal; Play; Predisposition; Pregnancy; Prevalence; Prevention; Proteins; Randomized; Recommendation; Research; Research Personnel; Risk; Role; Sampling; Secretory Immunoglobulin A; Specificity; Testing; Training; Translational Research; Work; base; career; career development; cohort; evidence based guidelines; feeding; food allergen; food antigen; human disease; interest; medical schools; mother nutrition; neonate; offspring; oral tolerance; pathogen; pregnant; response; responsible research conduct; skills; uptake

DESCRIPTION (provided by applicant): Currently, clear dietary recommendations for pregnant and breastfeeding mothers are lacking regarding allergy prevention in allergic or non-allergic families, although there is a great need to have firm evidence-based guidelines to advise families. Human studies to investigate the effect of strict food allergen avoidance, such as peanut, during pregnancy and lactation on the infant's risk towards development of food allergy are difficult to perform and potentially unethical. Animal studies have suggested that tolerance is induced by perinatal feeding of antigen. These studies have assessed naive mothers to assess risk of OVA-triggered asthma and peanut-allergic mothers to assess risk of peanut allergy. The novelty of this proposal is to assess mothers who are tolerant to the food in question, which is relevant to most of the humans. In the current proposal, we therefore aim to address the effect of feeding peanut during lactation on the offspring's predisposition toward allergic sensitization using an animal model of peanut allergy. We also aim to determine the potential mechanism of oral tolerance development provided via maternal milk. These animal studies will establish biological basis for maternal and infant feeding guidelines in order to address the increasing frequency of food allergies. Once basic mechanisms of this protection against or increased risk towards food allergy have been detected, the future studies could be performed in a human cohort of mothers who choose or do not choose to adhere to avoidance diets. My immediate goal is to obtain intensive training in immunobiology and experimental models of food allergy to add to my skills in mucosal immunology and maternal-infant interface of immunity. As a long-term goal, I strive to pursue a career in translational research to utilize both my skills in basic research as well as patient care and with that would like to develop into an independent research investigator. The proposed career development activities are a combination of coursework and informal training that will strengthen my knowledge and research skills in immunobiology applied to oral tolerance development. The Pediatric Allergy and Immunology Division and The Immunology Institute Mount Sinai School of Medicine provide an excellent forum for these activities, which include informal interactions with the faculty as well as formal courses in immunobiology and biostatistics, journal clubs, seminars and work-in- progress presentations, as well as training in responsible conduct of research. NARRATIVE: This research aims to solve a health concern of great public interest: should breastfeeding mothers avoid or eat potential food allergens in order to avoid development of food allergy in their children.

描述（由申请人提供）：目前，对于过敏或非过敏家庭的过敏预防，缺乏针对怀孕和哺乳母亲的明确饮食建议，尽管非常需要有可靠的循证指南来为家庭提供建议。人体研究旨在调查怀孕和哺乳期间严格避免食物过敏原（例如花生）对婴儿发生食物过敏的风险的影响，但这项研究很难进行，而且可能不道德。动物研究表明，围产期喂养抗原可诱导耐受。这些研究对未出生的母亲进行了评估，以评估 OVA 引发的哮喘风险，并对花生过敏的母亲进行评估，以评估花生过敏的风险。该提案的新颖之处在于评估母亲对相关食物的耐受性，这与大多数人类相关。因此，在当前的提案中，我们的目标是利用花生过敏的动物模型来解决哺乳期喂养花生对后代过敏倾向的影响。我们还旨在确定通过母乳提供的口服耐受性发展的潜在机制。这些动物研究将为孕产妇和婴儿喂养指南奠定生物学基础，以解决日益增加的食物过敏问题。一旦发现了这种预防食物过敏或增加食物过敏风险的基本机制，未来的研究就可以在选择或不选择坚持回避饮食的母亲群体中进行。 我的近期目标是获得免疫生物学和食物过敏实验模型方面的强化培训，以提高我在粘膜免疫学和母婴免疫界面方面的技能。作为一个长期目标，我努力从事转化研究职业，以利用我在基础研究和患者护理方面的技能，并希望发展成为一名独立的研究人员。拟议的职业发展活动是课程作业和非正式培训的结合，这将加强我在应用于口服耐受性发展的免疫生物学方面的知识和研究技能。儿科过敏和免疫学部门和西奈山医学院免疫学研究所为这些活动提供了一个极好的论坛，其中包括与教师的非正式互动以及免疫生物学和生物统计学的正式课程、期刊俱乐部、研讨会和正在进行的工作。演讲以及负责任的研究行为培训。 叙述：这项研究旨在解决一个备受公众关注的健康问题：母乳喂养的母亲是否应该避免或食用潜在的食物过敏原，以避免孩子发生食物过敏。