Coordinating Center to Help Eliminate/Reduce Oral health Inequalities in Children

帮助消除/减少儿童口腔健康不平等的协调中心

• 批准号: 8984700
• 负责人: STUART A GANSKY
• 金额: $ 220万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-18 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8984700
• 关键词: Address; Adherence; Advisory Committees; Area; Behavioral Sciences; Biometry; Calendar; Child; Childhood; Clinical; Clinical Research; Clinical Trials Data Monitoring Committees; Communities; Consult; Contractor; Cost Analysis; Cost Measures; Custom; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Quality; Data Set; Dental caries; Electronics; Ensure; Funding; Goals; Health; Health Policy; Health Sciences; Informatics; Information Systems; Institution; Knowledge; Manuals; Measurement; Measures; Microbiology; Monitor; National Heart, Lung, and Blood Institute; National Institute of Dental and Craniofacial Research; Oral health; Outcome; Participant; Persons; Phase; Policies; Population; Positioning Attribute; Procedures; Process; Progress Reports; Protocols documentation; Publications; Quality Control; Randomized Clinical Trials; Report (document); Reporting; Research; Research Design; Research Personnel; Research Project Grants; Safety; Sample Size; Schedule; Secure; Services; Site; Social Sciences; System; Teleconferences; Time; Training; U-Series Cooperative Agreements; United States National Institutes of Health; Videoconferences; Videoconferencing; Vulnerable Populations; aged; base; clinically relevant; data acquisition; data integrity; data management; design; early childhood; effective intervention; experience; falls; flexibility; follow-up; genetic epidemiology; health disparity; health economics; health inequalities; instrument; instrumentation; intervention program; meetings; multidisciplinary; operation; programs; public health relevance; quality assurance; screening; skills; statistics; tool; web site; working group

 DESCRIPTION (provided by applicant): The proposed "Coordinating Center to Help Eliminate/Reduce Oral health Inequalities in Children" (CC HEROIC; CC for short) will provide collaborative research and coordinating center expertise and services to 8 two-phase UH2/UH3 NIDCR-funded community-engaged projects (RFA-DE-15-006) to assess multilevel interventions, programs or policies to reduce or eliminate oral health disparities in diverse, vulnerable populations of children aged 0 to 21 years. The UH2/UH3 project PD/PIs, the NIDCR, and the CC will form a collaborative research consortium. The 8 projects will address a range of multilevel mechanisms of action with multidisciplinary teams. The proposed CC investigator and staff team possesses relevant transdisciplinary expertise in oral health, social and behavioral sciences, microbiology, genetics, epidemiology, health policy, health economics, and biostatistics, plus data coordinating center experience serving multiple health and oral health projects within NIH research consortia. As the NIDCR Early Child Caries Collaborating Centers Data Coordinating Center (NIDCR EC4 DCC) the team has demonstrated its ability to collaboratively and creatively support large-scale, clinically-relevant, and community-engaged oral health disparities research simultaneously in 6 UH2-like studies and then in 4 UH3-like randomized clinical trials in 6 institutions across 3 time zones to meet the overall scientific and project community partner goals. We will utilize both the NHLBI Compendium of Best Practices for Data Coordinating Centers as well as the Community-Campus Partnership in Health's Position Statement on Authentic Partnerships. The CC will establish ongoing, collaborative relationships with each UH2/UH3 project to provide services and expertise in the following areas: (a) oral health-related clinical knowledge; (b) qualitative and quantitative research design with particular emphasis on oral health outcomes in diverse, community-based, pediatric populations; (c) selecting cost measures and designing cost analyses; (d) selecting, developing, and refining measurement instruments, including harmonizing measures across the 8 UH2/UH3 projects; (e) informatics, including providing secure, customized data acquisition systems and project and clinical research management systems; (f) training in the use of those systems; (g) participant safety monitoring and reporting to the project investigators, NIDCR, the clinical operations contractor, and an independent Data and Safety Monitoring Board (DMSB); (h) data management, processing, and quality control; (i) developing qualitative and quantitative data analysis plans; (j) reporting on project progress to the project investigators, NIDCR, and the Data and Safety Monitoring Board; and (k) coordinate and participate in consortium meetings including regular Steering Committee, ad hoc Collaborating Working Group, and annual External Scientific Advisory Committee (ESAC) meetings. Our experienced children's oral health coordinating center team can provide efficient, comprehensive support to these UH2/UH3 projects to assure scientific rigor and meet community needs.

 DESCRIPTION (provided by applicable): The proposed "Coordinating Center to Help Eliminate/Reduce Oral Health Inequalities in Children" (CC HEROIC; CC for short) will provide collaborative research and coordination center expertise and services to 8 two-phase UH2/UH3 NIDCR-funded community-engaged projects (RFA-DE-15-006) to assess multilevel interventions, programs or policies to reduce or eliminate oral health潜水员的差异，脆弱的0至21岁儿童。 UH2/UH3 Project PD/PIS，NIDCR和CC将组成一个协作研究联盟。这8个项目将与多学科团队一起解决一系列的多级行动机制。拟议中的CC研究者和参谋队在口腔健康，社会和行为科学，微生物学，遗传学，流行病学，健康政策，健康经济学和生物统计学方面具有相关的跨学科专业知识，以及数据协调中心的经验，为NIH研究会议中的多个健康和口腔健康项目提供服务。 As the NIDCR Early Child Caries Collaborating Centers Data Coordinating Center (NIDCR EC4 DCC) the team has demonstrated its ability to collaboratively and creatively support large-scale, clinically-relevant, and community-engaged oral health distributions research simply in 6 UH2-like studies and then in 4 UH3-like randomized clinical trials in 6 institutions across 3 time zones to meet the overall scientific and 项目社区合作伙伴目标。我们将同时利用NHLBI的最佳实践汇编，用于数据协调中心，以及在Health的真实合作伙伴关系的职位声明中的社区校园合作伙伴关系。 CC将与每个UH2/UH3项目建立持续的协作关系，以在以下领域提供服务和专业知识：（a）与口腔健康相关的临床知识； （b）定性和定量研究设计 特别强调潜水员的口腔健康结果，基于社区的儿科人群； （c）选择成本衡量和设计成本分析； （d）选择，开发和完善测量工具，包括在8个UH2/UH3项目中进行协调测量； （e）信息，包括提供安全的，定制的数据采集系统以及项目和临床研究管理系统； （f）培训这些系统的使用； （g）参与安全监控和向项目调查人员，NIDCR，临床操作承包商以及独立数据和安全监测委员会（DMSB）报告； （h）数据管理，处理和质量控制； （i）制定定性和定量数据分析计划； （j）向项目调查人员NIDCR和数据和安全监控委员会报告项目进度； （k）协调并参加联盟会议，包括常规指导委员会，临时合作工作组和年度外部科学咨询委员会（ESAC）会议。我们经验丰富的儿童口腔健康协调中心团队可以为这些UH2/UH3项目提供高效，全面的支持，以确保科学严格并满足社区需求。