Mortality in a community sample of adults with arthritis

成人关节炎患者社区样本的死亡率

• 批准号: 8735617
• 负责人: LEIGH Fleming CALLAHAN
• 金额: $ 26.33万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-16 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735617
• 关键词: Adult; Affect; African American; Arthritis; Cardiovascular Diseases; Caring; Caucasians; Caucasoid Race; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chronic; Clinical; Communities; Comorbidity; County; Data; Degenerative polyarthritis; Diabetes Mellitus; Disease; Funding; Future; Gender; General Population; Goals; Health; Hip Osteoarthritis; Individual; Kidney Diseases; Knee; Measures; Mediating; Modeling; Morbidity - disease rate; Musculoskeletal Diseases; Not Hispanic or Latino; Obesity; Obesity associated cancer; Obesity associated cardiovascular disease; Operative Surgical Procedures; Pain; Parents; Participant; Patients; Physical activity; Policy Developments; Population; Prevalence; Process; Public Health; Quality of life; Quality-Adjusted Life Years; Race; Risk Factors; Sampling; Severities; Socioeconomic Status; Source; Symptoms; Time; United States National Center for Health Statistics; Visit; Vital Status; Woman; aged; attributable mortality; cohort; comparison group; design; disability; follow-up; indexing; low socioeconomic status; men; mortality; novel; parent project; population based; pre-clinical; prospective; psychosocial; public health relevance; repository

DESCRIPTION (provided by applicant): The goal of this ancillary proposal to the Johnston County Osteoarthritis (JoCo OA) Project: Arthritis and Disability (1U01DP003206-01 - funded by the CDC) is to create a repository of enhanced vital status, date and cause of death for participants during their current follow-up and to examine the contribution of knee and/or hip OA to mortality in non-Hispanic African-American (AA) and Caucasian men and women. The parent study was designed to encompass multiple aspects of the OA process from the biomedical to the psychosocial and from the pre-clinical to disability. Examining mortality in this cohort with u to 25 years of observation and extensive OA and chronic conditions data over multiple time points provides the perfect opportunity to answer these questions in ways other studies could not, and additionally, enhance the parent project. The goal will be accomplished with these 3 specific aims and a 4th exploratory aim: 1) to create a repository of enhanced vital status data in the 20+ year follow-up of the JoCo OA with the date and cause of death; 2) to determine whether knee and/or hip OA at baseline is associated with excess all-cause or disease-specific mortality, independent of concomitant comorbidities and obesity, and whether it is modified separately by gender, by race, and by socioeconomic status; 3) to evaluate the combined impact of OA and obesity, diabetes mellitus or cardiovascular disease on all-cause and disease specific mortality; and 4) to explore whether OA severity and persistence of symptoms of OA impacts all-cause and disease-specific mortality.

描述（由申请人提供）：对约翰斯顿县骨关节炎（JOCO OA）的该辅助提案的目标：关节炎和残疾（1U01DP003206-01-由CDC资助）是为了创建对参与者在其目前的重要状态，日期和撰写的重要状态和撰写的杂物的重大状态的恢复，并撰写oa的撰写，或者撰写的贡献，或者撰写的贡献，或者撰写的贡献，或者撰写的贡献或造成了贡献。非西班牙裔非裔美国人（AA）和高加索男女。父母研究旨在涵盖从生物医学到社会心理以及从临床前到残疾的多个方面。在该队列中检查死亡率与U 25年的观察以及在多个时间点上的大量OA和慢性条件数据提供了一个完美的机会，可以以其他研究无法（另外）来回答这些问题。目标将通过这三个特定目标和第四探索目的来实现：1）在中创建增强的重要状态数据的存储库 Joco OA的20年以上随访日期和死亡原因； 2）确定基线时的膝盖和/或髋关节OA是否与过量的全因或特定疾病的死亡率有关，独立于同时合并症和肥胖症，以及是否通过性别，种族和社会经济地位分别通过性别进行了修改； 3）评估OA和肥胖症，糖尿病或心血管疾病对全因和疾病特定死亡率的综合影响； 4）探索OA的严重程度和OA症状的持久性是否会影响全因和疾病特定的死亡率。