Field-ready and rapid trace-level detection and speciation of arsenic in water

现场快速痕量检测和水中砷的形态分析

• 批准号: 8832631
• 负责人: Merwan Benhabib
• 金额: $ 15万
• 依托单位: ONDAVIA, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-22 至 2015-02-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8832631
• 关键词: AA Spectrophotometry; Achievement; Adhesions; Affect; Anions; Arsenates; Arsenic; Arsenites; Calibration; California; Cancer Etiology; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Chemicals; Chromatography; Chronic; Data; Decontamination; Detection; Devices; Diabetes Mellitus; Digit structure; Early Diagnosis; Elements; Environment; Equipment; Exposure to; Funding; Future; Generations; Gold; Health; Human; Hybrids; Ions; Iron; Kidney Diseases; Laboratories; Lead; Legal patent; Liver diseases; Lung diseases; Measurement; Metals; Microfluidics; Monitor; Morphology; National Institute of Environmental Health Sciences; Perchlorates; Performance; Phase; Policy Maker; Prevention; Public Health; Publishing; Raman Spectrum Analysis; Regulation; Research; Sampling; Signal Transduction; Site; Small Business Innovation Research Grant; Solutions; Source; Superfund; Surface; Surveys; System; Technology; Testing; Thick; Time; Toxic effect; Water; Work; cancer type; commercialization; design; drinking water; improved; industry partner; innovation; interest; iron oxide; nanoparticle; novel; oxidation; plasmonics; pollutant; programs; public health relevance; remediation; response; success; superfund site; tool; water sampling

DESCRIPTION (provided by applicant): Arsenic in drinking water is a proven cause of cancer, and continues to pose a significant human and environmental threat in the U.S and globally. Arsenic has been found in drinking water in forty-nine States and constitutes a major pollutant in many Superfund sites. This omnipresence requires adequate monitoring equipment that is not only fast, but also combines the sensitivity and performance of laboratory-grade equipment with the ease-of-use and mobility of test kits. OndaVia has developed an analytical platform using Surface-Enhanced Raman Spectroscopy (SERS) for trace chemical detection in water. This platform successfully demonstrated reliable detection of trace- levels of perchlorate at a California decontamination site. OndaVia proposes to adapt its inexpensive, field-deployable and robust solution for ultra-sensitive and rapid arsenic monitoring. This novel innovation, capable of speciation and quantitative arsenic measurement at ppb (parts per billion) levels in water, will help reduce arsenic exposure and advance the prevention for arsenic-induced illnesses. It will critically enhance early detection, help site-prioritization and decontamination efforts, improve testing capabilities of small- and medium-sized water systems, and assist policy makers fill gaps in water regulation. OndaVia's technology relies on an inexpensive microfluidic chip that embeds gold nanoparticles to form a robust, reliable and effective plasmonic enhancement substrate within a microchannel. In SERS, enhancements are obtained when the analytes interact or adhere to the surface of the plasmonic metal. To obtain single-digit ppb detection of arsenic, OndaVia proposes to embed a new generation of gold- nanoparticles specifically designed for arsenic detection. Funding will be used to synthesize, characterize, and optimize the innovative nanoparticles, build and calibrate the new substrate using lab-standards, and finally quantify and speciate arsenic in real-world water samples.

描述（由申请人提供）：饮用水中的砷已被证明是导致癌症的原因，并且继续对美国和全球的人类和环境构成重大威胁。砷已在四十九个州的饮用水中被发现，并构成许多超级基金地点的主要污染物。这种无所不在的情况需要足够的监测设备，这些设备不仅速度快，而且将实验室级设备的灵敏度和性能与测试套件的易用性和移动性结合起来。 OndaVia 开发了一个使用表面增强拉曼光谱 (SERS) 的分析平台，用于水中的痕量化学物质检测。该平台成功地证明了在加利福尼亚州净化现场能够可靠地检测痕量高氯酸盐。 OndaVia 建议采用其廉价、可现场部署且强大的解决方案来实现超灵敏和快速的砷监测。这项新颖的创新能够对水中 ppb（十亿分之一）水平的砷形态进行定量测量，将有助于减少砷暴露并促进砷引起的疾病的预防。它将极大地增强早期检测，帮助确定现场优先顺序和净化 努力，提高中小型水系统的检测能力，并协助政策制定者填补水监管空白。 OndaVia 的技术依赖于一种廉价的微流控芯片，该芯片嵌入金纳米粒子，在微通道内形成坚固、可靠且有效的等离子体增强基板。在 SERS 中，当分析物相互作用或粘附到等离子体金属表面时，就会获得增强。为了实现砷的个位数 ppb 检测，OndaVia 建议嵌入专为砷检测而设计的新一代金纳米颗粒。资金将用于合成、表征和优化创新纳米颗粒，使用实验室标准构建和校准新基质，最后对现实水样中的砷进行定量和形态分析。