Renovation of the cage wash facility at the MCG animal facility in Gracewood, GA

乔治亚州 Gracewood 的 MCG 动物设施的笼子清洗设施翻新

• 批准号: 8184269
• 负责人: ALVIN V TERRY
• 金额: $ 26.08万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2013-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8184269
• 关键词: Address; Aging; Animal Model; Appointment; Area; Basic Science; Behavioral; Bioinformatics; Biomedical Research; Biometry; Cancer Center; Canis familiaris; Cardiovascular Diseases; Child health care; Clinical; Clinical Research; Diabetes Mellitus; Employee; Ensure; Epidemiology; Equipment; Excision; Extramural Activities; Faculty; Family suidae; Floor; Funding; Grant; Growth; Health Sciences; Infection; Inflammation; Institutes; Institution; Laboratory Animals; Malignant Neoplasms; Molecular Genetics; NCI Center for Cancer Research; National Cancer Institute; Obesity; Patients; Physiological; Positioning Attribute; Public Health; Research; Research Infrastructure; Research Personnel; Rodent; Safety; School Dentistry; Surface; System; Translational Research; United States National Institutes of Health; Vision; Work; aged; animal care; animal facility; base; brain behavior; building renovation; human disease; medical schools; nonhuman primate; operation; programs; research facility; sound; translational study; wasting

DESCRIPTION (provided by applicant): MCG concentrates its research efforts into seven areas of focus: brain and behavior, cancer, cardiovascular disease, child health, diabetes/obesity, infection/inflammation and vision. The institutions research-related initiatives include: 7 Optimizing Discovery Institutes to interlink basic and translational research 7 Working to become a National Cancer Institute designated cancer center 7 Enhancing competitiveness for extramural research funding, particularly in basic, clinical, and translational studies 7 Enhancing research initiatives related to public health, particularly in biostatistics and epidemiology 7 Enhancing clinical research infrastructure in areas such as bioinformatics, biostatistics, and epidemiology to expand patient-based research A number of these programs utilize animal models of human diseases in which a wide range of molecular, genetic, behavioral and physiological approaches are employed. MCG has shown a 263.575% growth in biomedical research funding over the past 10 years. More than 60% of MCG's sponsored research funding comes from highly competitive National Institutes of Health grants which increased 119% in the School of Medicine in the past decade. The appointment and ongoing recruitment of new faculty, a rapidly expanding NIH funding base, multiple equipment purchases construction of the $40M (165,000 ft.2) Cancer Research Center, $34M (200,000 ft.2) Health Science Building, $110 M (274,900 ft. 2) School of Dentistry building and renovation of multiple basic science laboratories and animal facilities ($20M, 200,000 ft.2) position MCG to continue achieving further levels of excellence in biomedical research. The operation of a well-equipped, research facility is essential for MCG's continued recruitment of new research faculty, conduct of currently funded research and continued growth of its biomedical research programs. This significant growth of biomedical research at MCG is tempered by the aging equipment of the Animal Care Facility (ACF) located 12 miles away in Gracewood, GA. Aging of the facility's rack washer and bottle washer contribute to the lack of efficiency of the husbandry tasks that must be performed to ensure regulatory compliance and safety when handling waste and manipulanda used by various species (nonhuman primates, swine, canines and rodents). The decrease in efficiency can negatively impact the current group of researchers, ongoing recruitments and planned program expansion initiatives. Thus, this application is for support to renovate the animal facility cage wash facility at the Gracewood Animal Care Facility. The specific aims of this proposal are: 1. Removal of the aged cage rack washer and bottle washer 2. Installation of a pit to mount the new rack washer in in order for it to be level on grade 3. Installation of a new larger capacity and greener rack washer and bottle washer. 4. Install epoxy floor system in the associated cage wash areas, (360 ft2 ) These aims will address the increasing demands of the facility operations, provide a durable flooring surface for sanitization, implement ergonomically sound construction features for employee safety and facilitate the growing Green Sustainability Initiative of the Medical College of Georgia.

描述（由申请人提供）：MCG 将其研究工作集中在七个重点领域：大脑和行为、癌症、心血管疾病、儿童健康、糖尿病/肥胖、感染/炎症和视力。该机构与研究相关的举措包括： 7 优化发现研究所，将基础研究和转化研究联系起来 7 努力成为国家癌症研究所指定的癌症中心 7 增强校外研究经费的竞争力，特别是在基础、临床和转化研究方面 7 加强研究举措与公共卫生相关，特别是生物统计学和流行病学领域 7 加强生物信息学、生物统计学和流行病学等领域的临床研究基础设施，以扩大以患者为基础的研究其中一些项目利用人类疾病的动物模型，其中采用了广泛的分子、遗传、行为和生理学方法。过去 10 年，MCG 的生物医学研究经费增长了 263.575%。 MCG 超过 60% 的研究经费来自竞争激烈的国立卫生研究院的资助，在过去十年中，医学院的资助增加了 119%。新教师的任命和持续招聘、快速扩大的 NIH 资金基础、购买多种设备、建造 4,000 万美元（165,000 平方英尺）的癌症研究中心、3,400 万美元（200,000 平方英尺）的健康科学大楼、1.1 亿美元（274,900 平方英尺） ft. 2) 牙科学院建设和翻新多个基础科学实验室和动物设施（2000 万美元，200,000 ft.2) 使 MCG 能够继续在生物医学研究方面取得更高的卓越水平。设备齐全的研究设施的运营对于 MCG 继续招募新的研究人员、开展当前资助的研究以及持续发展其生物医学研究项目至关重要。 MCG 生物医学研究的显着增长受到 12 英里外佐治亚州格雷斯伍德动物护理设施 (ACF) 设备老化的影响。该设施的架式清洗机和洗瓶机老化导致饲养任务效率低下，而这些任务必须执行，以确保在处理各种物种（非人类灵长类动物、猪、犬科动物和啮齿动物）使用的废物和机械手时遵守法规和安全。效率的下降可能会对当前的研究人员群体、正在进行的招募和计划的项目扩展举措产生负面影响。因此，本申请旨在支持翻新 Gracewood 动物护理设施的动物设施笼子清洗设施。该提案的具体目标是： 1. 拆除老化的笼架式清洗机和洗瓶机 2. 安装一个坑，用于安装新的架式清洗机，使其与地面水平 3. 安装一个新的更大容量的清洗机以及更环保的架式清洗机和洗瓶机。 4. 在相关的笼子清洗区域（360 平方英尺）安装环氧地坪系统。这些目标将满足设施运营日益增长的需求，提供耐用的地板表面进行消毒，实施符合人体工程学的良好建筑功能以保障员工安全，并促进不断增长的绿色环保佐治亚医学院的可持续发展倡议。