Pain and Aging Research Translational Initiative

疼痛与衰老研究转化计划

• 批准号: 8764254
• 负责人: Roger B Fillingim
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8764254
• 关键词: ARHGEF5 gene; Academic Career Award; Address; Adult; Advisory Committees; Affect; Age; Aging; Applications Grants; Area; Award; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Development; Development Plans; Elderly; Ensure; Environment; Exhibits; Faculty; Florida; Fostering; Goals; Grant; Grant Review; Health Sciences; Impaired cognition; Inflammation; Institute of Medicine (U.S.); Institutes; Interdisciplinary Study; International; Intervention; Knowledge; Laboratories; Leadership; Link; Measures; Mentors; Motor; NIH Program Announcements; Neurobiology; Outcome; Pain; Pain Research; Pilot Projects; Postdoctoral Fellow; Process; Program Development; Public Health; Reporting; Research; Research Infrastructure; Research Personnel; Research Priority; Resources; Risk; Scientist; Series; Services; System; Time; Training Programs; Translational Research; Travel; United States National Institutes of Health; Universities; age related; career; career development; central pain; chronic pain; clinical risk; cohort; college; cost; design; doctoral student; experience; improved; meetings; multidisciplinary; next generation; patient oriented research; programs; psychosocial; public health relevance; research facility; response; skills; somatosensory; translational study

DESCRIPTION (provided by applicant): As detailed in a recent Institute of Medicine (IOM) report, chronic pain represents a major public health concern, affecting 100 million U.S. adults and costing more than $500 billion annually. Aging confers increased risk for chronic pain, with half of older adults reporting persistent or recurring pain, and aging is associated with greater pain-related loss of physical and psychosocial function. Current knowledge regarding pain and aging is surprisingly limited, and an improved understanding of the neurobiological and psychosocial mechanisms underlying age-related changes in pain is critical in order to inform interventions aimed at reducing pain in the elderly. Indeed, NIA recently has issued a series of Program Announcements encouraging studies of pain from an aging perspective (Pain in Aging PA-13-058, 059, & 060), identifying this as a high priority research topic. Our research group has documented age-related changes in laboratory measures of pain sensitivity and pain modulation, such that older adults exhibit enhanced pain facilitation (e.g. temporal summation of pain) and diminished pain inhibitory responses (e.g. conditioned pain modulation). The age-related changes in endogenous pain modulation may in part explain age-associated increases in risk for clinical pain. Advancing our understanding of pain and aging will require a coordinated translational research effort buttressed by sufficient infrastructure tailored for this purpose. Ths K07 Academic Career Award proposes to develop a University-wide program designed to facilitate and expand multidisciplinary research in pain and aging and to provide physical and logistical infrastructure to support pain and aging research efforts. In support of this goal, the I will pursue a career development plan designed to increase his expertise in aging research, enhance his leadership skills, and broaden his mentoring capacity. In addition, the PI will be supported in these endeavors by outstanding External and Internal Advisory Committees comprised of national and international leaders in their fields. The long-term outcome of this initiative will be to enhance the portfolio of pain and aging research at the University of Florida elevating it to national prominence. This research goal with be achieved by addressing the following specific aims: Specific Aim 1 - To develop an active and focused multidisciplinary translational research program on pain and aging at the University of Florida; Specific Aim 2: To enhance physical and logistical infrastructure in support of clinical and translational studies on pain and aging; Specific Aim 3: To foster the emergence of the next generation of geriatric pain scientists by providing resources and mentoring in pain and aging for junior scholars at all levels of career development. Ultimately, development of the UF Pain and Aging Research Translational Initiative will greatly enhance the local research environment and will move the field forward through cutting edge research investigating the mechanisms underlying age-related changes in the experience of pain.

描述（由申请人提供）：如最近一份医学研究所（IOM）报告所述，慢性疼痛代表了一个主要的公共卫生问题，影响了1亿美国成年人，每年耗资超过5亿美元。衰老赋予了慢性疼痛的风险增加，一半的老年人报告持续或反复出现的疼痛，并且衰老与身体和心理社会功能的疼痛丧失更大有关。目前，关于疼痛和衰老的知识令人惊讶地受到限制，并且对与年龄相关的疼痛变化的神经生物学和社会心理机制有了更高的了解，这对于旨在减少老年人疼痛的干预措施至关重要。确实，NIA最近发布了一系列计划公告，从老化的角度来鼓励对疼痛进行研究（老龄化PA-13-058、059和060的疼痛），将其确定为高优先研究主题。我们的研究小组记录了与年龄相关的实验室疼痛敏感性和疼痛调节措施的变化，以使老年人表现出增强的疼痛促进作用（例如，疼痛的时间刺激）和疼痛抑制作用减少（例如调节性疼痛调节）。内源性疼痛调节中与年龄相关的变化可能部分解释了与年龄相关的临床疼痛风险增加。促进我们对疼痛和衰老的理解将需要协调 翻译研究工作的支撑是为此量身定制的足够的基础设施。 THS K07学术职业奖建议制定一项旨在促进和扩大疼痛和衰老的多学科研究，并提供物理和后勤基础设施以支持疼痛和衰老研究工作的多学科研究。为了支持这一目标，我将制定一项职业发展计划，旨在提高他在老龄化研究，提高他的领导能力并扩大他的指导能力方面的专业知识。此外，PI将由由国家和国际领导人组成的杰出外部和内部咨询委员会在这些努力中得到支持。该计划的长期结果将是提高佛罗里达大学的疼痛和衰老研究组合，使其提高到国家的突出性。通过解决以下特定目的来实现这一研究目标：特定目的1-在佛罗里达大学开发有关疼痛和衰老的积极且重点的多学科转化研究计划；特定目的2：增强身体和后勤基础设施，以支持疼痛和衰老的临床和翻译研究；特定目的3：通过在各个级别为初级学者提供资源和指导，以促进下一代老年疼痛科学家的出现 职业发展。最终，UF疼痛和衰老研究转化计划的发展将大大改善当地研究环境，并通过尖端研究来向前发展，从而调查疼痛经历中与年龄相关的机制。