Sustainable Control of Aedes aegypti and epidemic dengue

埃及伊蚊和流行性登革热的可持续控制

• 批准号: 8688883
• 负责人: WILLIAM C. BLACK
• 金额: $ 62.88万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8688883
• 关键词: Address; Adolescent; Adult; Aedes; Affect; Americas; Area; Biological Assay; Biosensor; Characteristics; Cities; Colorado; Communities; Culicidae; Data; Dengue; Dengue Hemorrhagic Fever; Dengue Virus; Domiciles; Effectiveness; Enrollment; Epidemic; Epidemiologic Studies; Epidemiology; Evaluation; Evolution; Feeds; Female; Filariasis; Frequencies; Genes; Goals; Home environment; Household; Housing; Human; Individual; Infection; Insecticides; Institution; Intervention; Intervention Studies; Malaria; Measures; Mexico; Modeling; Molecular Genetics; Mutation; Outcome; Outcome Study; Participant; Prevention; Principal Investigator; Public Health; Randomized; Resistance; Resistance profile; Seasons; Sodium Channel; Source; Technology; Universities; Vaccines; Vector-transmitted infectious disease; Virus; Virus Diseases; arm; decamethrin; design; feeding; knock-down; metropolitan; novel strategies; pathogen; prevent; programs; pyrethroid; stem; tool; transmission process; vector; vector control; vector mosquito; vector transmission; voltage; Address; Adolescent; Adult; Aedes; Affect; Americas; Area; Biological Assay; Biosensor; Characteristics; Cities; Colorado; Communities; Culicidae; Data; Dengue; Dengue Hemorrhagic Fever; Dengue Virus; Domiciles; Effectiveness; Enrollment; Epidemic; Epidemiologic Studies; Epidemiology; Evaluation; Evolution; Feeds; Female; Filariasis; Frequencies; Genes; Goals; Home environment; Household; Housing; Human; Individual; Infection; Insecticides; Institution; Intervention; Intervention Studies; Malaria; Measures; Mexico; Modeling; Molecular Genetics; Mutation; Outcome; Outcome Study; Participant; Prevention; Principal Investigator; Public Health; Randomized; Resistance; Resistance profile; Seasons; Sodium Channel; Source; Technology; Universities; Vaccines; Vector-transmitted infectious disease; Virus; Virus Diseases; arm; decamethrin; design; feeding; knock-down; metropolitan; novel strategies; pathogen; prevent; programs; pyrethroid; stem; tool; transmission process; vector; vector control; vector mosquito; vector transmission; voltage

DESCRIPTION (provided by applicant): Epidemic dengue fever and dengue hemorrhagic fever are major public health problems in the Americas. Current control measures used against the primary dengue virus (DENV) mosquito vector, Aedes aegypti, include source reduction to control juveniles and space spraying to control adults. This has not proven to be sufficient or sustainable to stem the tide of dengue. New approaches are needed to control Ae. aegypti and prevent dengue infections. Aedes aegypti feeds predominantly indoors and almost exclusively on humans. The Casa Segura ("safe house") exploits long-lasting insecticide-treated materials in the form of deltamethrin-treated curtains to preclude Ae. aegypti from the home: the epidemiologically most significant point of contact between this vector and humans. The Casa Segura prevents infected vectors from entering homes and transmitting DENV to humans or uninfected vectors from becoming infected when feeding on DENV-infected humans in the home, thereby interrupting virus transmission at two points in the mosquito-human cycle. Casa Segura offers the exciting promise of sustainable prevention and perhaps even local elimination of dengue. The effectiveness of the Casa Segura to reduce dengue is predicated upon operational effectiveness of pyrethroid insecticides. Knock-down resistance (kdr) to pyrethroids has emerged in Ae. aegypti in the tropical world, but little is known about the extent to which this may adversely affect operational vector control. In this ICIDR program, we will: 1) demonstrate in a metropolitan setting (Merida, Mexico) that the Casa Segura reduces indoor abundance of DENV-infected Ae. aegypti females and dengue infections among the residents, 2) reveal the potential operational effects of kdr on the entomological and epidemiological study outcomes, and 3) determine if the Casa Segura promotes evolution of kdr in Ae. aegypti. The ICIDR consortium will include Colorado State University, Universidad Autonoma de Nuevo Leon, and Universidad Autonoma de Yucatan. Our overarching goals are to: 1) develop a broadly applicable, inexpensive and sustainable approach to make homes in the developing world as safe as those in the developed world from transmission of vector-borne pathogens, and 2) to transfer tools and technologies to our consortium and other institutions in dengue-endemic areas. RELEVANCE : The emergence of epidemic dengue fever and dengue hemorrhagic fever in the Americas is a public health catastrophe. There is no vaccine for dengue; thus more effective vector control is critical. The Casa Segura potentially provides a long term inexpensive approach to preventing dengue virus transmission in the home. The approach may also be applicable to other globally important vector borne diseases, such as malaria, filariasis, and Chagas, which are also transmitted principally in the home.

描述（由申请人提供）：流行登革热和登革热出血热是美洲的主要公共卫生问题。目前针对原发性登革热病毒（DENV）蚊子载体艾德斯埃及埃及的控制措施包括减少来源以控制少年和喷雾以控制成年人。事实证明，这尚未足够或可持续来阻止登革热的潮流。需要新的方法来控制AE。埃及并防止登革热感染。埃及埃及主要在室内和几乎完全以人类为食。 Casa Segura（“ Safe House”）以经过三甲蛋白处理的窗帘的形式利用了持久的杀虫剂处理的材料，以阻止AE。来自家里的埃及：该向量与人类之间最重要的接触点。 CASA Segura防止感染的向量进入房屋，并将DENV传输到人类或未感染的载体在家庭中以DENV感染的人为食时被感染，从而在蚊子循环中的两个点上断病毒传播。卡萨·塞古拉（Casa Segura）提供了令人兴奋的预防预防，甚至可以当地消除登革热的希望。 CASA Segura减少登革热的有效性是基于拟除虫菊酯杀虫剂的作战有效性的。 AE中出现了对拟除虫菊酯的敲低阻力（KDR）。埃及在热带世界中，但对这可能会对操作向量控制的影响程度知之甚少。在此ICIDR计划中，我们将：1）在大都会环境（墨西哥梅里达）中演示Casa Segura减少了DENV感染的AE的室内丰度。居民之间的埃及女性和登革热感染，2）揭示了KDR对昆虫学和流行病学研究结果的潜在操作作用，3）确定CASA Segura是否促进了AE中KDR的演变。埃及。 ICIDR联盟将包括科罗拉多州立大学，自主大学Leon大学和Yucatan大学。我们的总体目标是：1）开发一种广泛，廉价和可持续的方法，使发展中国家的房屋像发达国家一样安全，从发达世界中的媒介传播病原体以及2）将工具和技术转移到我们的财团和其他机构中，并将其转移到登顶领域。 相关性：美洲流行病登革热和登革热出血热的出现是一场公共卫生灾难。登革热没有疫苗；因此，更有效的向量控制至关重要。 Casa Segura可能提供了一种长期廉价的方法来防止家庭中的登革热传播。该方法也可能适用于其他全球重要的媒介传播疾病，例如疟疾，丝虫病和Chagas，这些疾病也主要在家庭中传播。