Dietary and Hormonal Determinants of Cancer in Women

女性癌症的饮食和激素决定因素

• 批准号: 8662722
• 负责人: Meir Stampfer
• 金额: $ 471.52万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-12 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8662722
• 关键词: Acrylamides; Address; Affect; Age-Years; Alcohol consumption; Archives; Area; Aspirin; Biological Assay; Biological Markers; Blood; Blood specimen; Body mass index; Cancer Center; Carbon; Cells; Cessation of life; Characteristics; Chronic Disease; Clinical; Collaborations; Colon Carcinoma; Colorectal Cancer; Complex; Coupled; DNA; Data; Data Analyses; Data Collection; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Diet; Dietary Factors; Dietary intake; Disease; Disease Management; Endometrial; Endometrial Carcinoma; Environment; Etiology; Evaluation; Fatal Outcome; Fatty-acid synthase; Fertilization; Flavonoids; Funding; Gene Expression; Genes; Genetic Determinism; Genetic Polymorphism; Genetic Risk; Glioma; Grant; Health Personnel; Heart Diseases; Hormonal; Hormonal Risk Factor; Hormone Receptor; Human Resources; Incidence; Inflammation; Inflammatory; Insulin; Insulin Resistance Pathway; Intake; Investigation; Kidney; Knowledge; Lactose; Late Effects; Leadership; Life; Logistic Regressions; Lymphoma; Maintenance; Malignant Neoplasms; Malignant neoplasm of ovary; Mammary Neoplasms; Mammography; Manuscripts; Measures; Medicine; Melatonin; Methods; Methylation; Modeling; Molecular; Multiple Myeloma; National Cancer Institute; Non obese; Nurses' Health Study; Nutrient; Nutritional; Obesity; PTGS2 gene; Pancreas; Paraffin Embedding; Participant; Pathway interactions; Peptides; Physical activity; Plasma; Preparation; Prevention; Principal Investigator; Productivity; Prospective Studies; Proteins; Questionnaires; Recruitment Activity; Recurrence; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Somatomedins; Specimen; Statistical Methods; Statistical Models; Structure; The Sun; Time; Tumor Markers; Tumor Subtype; Tumor Tissue; Universities; Update; Urine; Vitamin D; Washington; Woman; Wound Healing; adiponectin; base; cancer genome; cancer risk; case control; clinically relevant; cohort; cost; data sharing; energy balance; follow-up; genetic risk factor; genome wide association study; improved; indexing; inflammatory marker; insight; lifestyle factors; malignant breast neoplasm; meetings; melanoma; member; modifiable risk; mortality; novel; professor; programs; sample collection; shift work; success; tumor; urinary

DESCRIPTION (provided by applicant): The long-term objective of this Program Project is to identify novel hormonal, dietary and genetic determinants of cancer risk (specifically breast, colorectal, and ovarian cancers) in v\/omen, with the aim of finding means for prevention and improved survival. The availability of questionnaire data, blood and urine samples and paraffin-embedded tumor tissue, coupled with up to 36 years follow-up, affords the opportunity to further understand the time course, as well as mechanisms of cancer development. Cross-cutting themes include the investigation of vitamin D and melatonin, energy balance and inflammatory pathways, as well as the examination of fatal outcomes and the molecular characterization of tumors. In Project 1, we will examine vitamin D, melatonin, and dietary intake (including 1-carbon nutrients and change in alcohol intake) in relation to breast cancer risk; further, risk factors for clinically relevant tumor subtypes and fatal disease will be assessed. We will assess the contribution of modifiable factors to incidence in women at high genetic risk. Further the role of energy balance in survival will be assessed. In Project 2, we will assess vitamin D and melatonin, including associations with tumor characteristics. The roles of insulin, adiponectin and insulin-like growth factors as well as inflammation markers in colon cancer incidence and survival will be assessed, in Project 3, we will evaluate vitamin D, melatonin, dietary factors (flavonoids, lactose and acrylamide) and plasma markers of inflammation in relation to ovarian cancer risk. Further, we will assess tumor markers in relation to ovarian cancer risk factors, as well as risk factors for fatal disease. In Project 4, we will extend and apply analytic methods that will improve our modeling of cumulative exposures that influence risk at different times in life, extend polytomous logistic regression models in a complex tumor biomarker setting, and improve evaluation of breast and colon cancer risk prediction models. This application is based on the Nurses' Health Study cohort, comprising 121,700 women who were 30 to 55 years of age in 1976. Through funding of the Cores, we maintain follow-up of the cohort and confirmation of incident cancers and deaths, oversee acquisition and use of biomarkers and provide leadership and data analysis. The Nurses' Health Study as funded through this Program Project contributes to the NCI sponsored Cohort Consortium, belongs to 12 other consortia and has served as the research platform for over 30 outside collaborators over the last 5 years.

描述（由申请人提供）：该计划项目的长期目标是在V \/emen中识别癌症风险的新型荷尔蒙，饮食和遗传决定因素（特别是乳腺癌，结直肠癌和卵巢癌），目的是寻找预防和改善生存的方法。问卷数据，血液和尿液样本以及石蜡包裹的肿瘤组织的可用性，再加上长达36年的随访，为进一步了解时间过程以及癌症发展的机制提供了机会。跨切割主题包括对维生素D和褪黑激素的研究，能量平衡和炎症途径，以及致命结局的检查以及肿瘤的分子表征。 在项目1中，我们将研究与乳腺癌风险有关的维生素D，褪黑激素和饮食摄入（包括1-碳养分和酒精摄入的变化）；此外，将评估临床相关肿瘤亚型和致命疾病的危险因素。我们将评估可修改因素对处于高遗传风险的女性发病率的贡献。进一步将评估能量平衡在生存中的作用。 在项目2中，我们将评估维生素D和褪黑激素，包括与肿瘤特征的关联。将评估胰岛素，脂联素和胰岛素样生长因子以及炎症标志物在结肠癌发病率和生存中的作用，将在项目3中评估，我们将评估维生素D，褪黑激素，饮食因素（黄酮类动物，乳糖和丙烯酰胺和丙烯酰胺）和相关性炎症的血浆标志。此外，我们将评估与卵巢癌危险因素以及致命疾病的危险因素有关的肿瘤标志物。在项目4中，我们将扩展和应用分析方法，这些方法将改善我们对在复杂的肿瘤生物标志物环境中的多态逻辑回归模型的影响累积暴露的建模，并改善对乳腺癌和结肠癌风险预测模型的评估。 该申请基于护士健康研究队列，包括1976年30至55岁的121,700名妇女。通过资助核心，我们维持了对队列的随访以及事件癌和死亡，监督生物标志物的收购和使用，并提供领导和数据分析。通过该计划项目资助的护士健康研究为NCI赞助的队列联盟做出了贡献，属于其他12个联盟，并在过去5年中一直是30多个外部合作者的研究平台。