Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study

女性癌症的长期多学科研究：护士健康研究

• 批准号: 8699413
• 负责人: Meir Stampfer
• 金额: $ 297.21万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-22 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8699413
• 关键词: Address; Age; Aging; Archives; Behavior; Behavioral; Behavioral Genetics; Big Data; Biological Markers; Blood; Blood specimen; Body mass index; Breast; Cancer Etiology; Cancer Patient; Cancer Survivor; Cells; Collection; Colorectal; Colorectal Cancer; Complement; Complex; Computer software; DNA; Data; Data Analyses; Data Sources; Development; Diagnosis; Diagnostic; Environment; Etiology; Film; Future; Genomics; Goals; Health; Health Policy; Heterogeneity; Incidence; Institute of Medicine (U.S.); Investments; Leadership; Life Style; Mails; Malignant Neoplasms; Mammography; Measurement; Measures; Medicare; Medicare claim; Mental Health; Methods; Morbidity - disease rate; Nurses' Health Study; Ovarian; Participant; Pathway interactions; Physical Function; Physical activity; Pilot Projects; Plasma; Positioning Attribute; Prevention; Preventive; Procedures; Quality of life; Questionnaires; Recurrence; Research; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Risk Factors; Sampling; Seminal; Specimen; Statistical Models; Structure; Structure of nail of toe; System; Systems Biology; Time; Time Study; Tissue Banks; Tissues; Tumor Tissue; United States National Institutes of Health; Update; Urine; Woman; Work; aged; base; behavior measurement; biobank; breast density; cancer diagnosis; cancer prevention; cancer site; cancer therapy; cohort; cost; data management; data sharing; digital; experience; follow-up; genome wide association study; health care service utilization; health economics; improved; innovation; malignant breast neoplasm; metabolomics; middle age; mortality; multidisciplinary; novel; repository; sample collection; screening; transcriptomics; tumor; Address; Age; Aging; Archives; Behavior; Behavioral; Behavioral Genetics; Big Data; Biological Markers; Blood; Blood specimen; Body mass index; Breast; Cancer Etiology; Cancer Patient; Cancer Survivor; Cells; Collection; Colorectal; Colorectal Cancer; Complement; Complex; Computer software; DNA; Data; Data Analyses; Data Sources; Development; Diagnosis; Diagnostic; Environment; Etiology; Film; Future; Genomics; Goals; Health; Health Policy; Heterogeneity; Incidence; Institute of Medicine (U.S.); Investments; Leadership; Life Style; Mails; Malignant Neoplasms; Mammography; Measurement; Measures; Medicare; Medicare claim; Mental Health; Methods; Morbidity - disease rate; Nurses' Health Study; Ovarian; Participant; Pathway interactions; Physical Function; Physical activity; Pilot Projects; Plasma; Positioning Attribute; Prevention; Preventive; Procedures; Quality of life; Questionnaires; Recurrence; Research; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Risk Factors; Sampling; Seminal; Specimen; Statistical Models; Structure; Structure of nail of toe; System; Systems Biology; Time; Time Study; Tissue Banks; Tissues; Tumor Tissue; United States National Institutes of Health; Update; Urine; Woman; Work; aged; base; behavior measurement; biobank; breast density; cancer diagnosis; cancer prevention; cancer site; cancer therapy; cohort; cost; data management; data sharing; digital; experience; follow-up; genome wide association study; health care service utilization; health economics; improved; innovation; malignant breast neoplasm; metabolomics; middle age; mortality; multidisciplinary; novel; repository; sample collection; screening; transcriptomics; tumor

DESCRIPTION (provided by applicant): This is a UIVII application to support the infrastructure of the original Nurses' Health Study (NHS). The NHS began in 1976 with 121,700 women, and has accumulated data from 19 questionnaires over 37 years; follow-up remains about 90 percent. The wealth of behavioral data combined with multiple bio-specimen collections, including blood, toenails, urine, buccal cells and tumor tissues beginning in 1.983 from a substantial proportion of women, provide an unparalleled resource in studying cancer prevention, etiology, and survival. Sustained follow-up of the NHS through repeated questionnaire mailings and continued identification of cancer incidence and mortality will permit critical new research. With the cohort's maturation (women are now 66+ years, at peak ages for cancer incidence), we propose to add emphasis to two overarching themes. First, we propose to expand the infrastructure for cancer survival research, including both the duration and quality of life in cancer patients. The many years of characterization of cancer patients before and after diagnosis, will allow us to distinguish between causes and consequences of cancer and its treatment. Second, we propose to improve our infrastructure to support a systems biology approach to our research, integrating questionnaire data with biomarkers in DNA, blood, tumor tissue, and other bio specimens; such research simultaneously integrating multiple "systems", including behavior, genomics, transcriptomics, metabolomics, etc., may illuminate new mechanisms underlying cancer. Our large and growing number of incident cancer cases, and the unique combination of questionnaires and bio specimens, are a necessity for such integrative research. Specifically, our Aims include new collection of quality of life data, new (collection of tumor tissue (resulting in tissue collections, across 17 cancer sites), improved dat management/statistical support for "big data" analyses, and enhanced infrastructure for data sharing (the NHS resource is already extensively utilized - we have provided access to >75 external investigators in the past 5-6 years and 27 NCI cancer consortia). The NHS structure combines the long experience of senior leaders with support of several developing leaders; this combination is purposeful, to maintain leadership to sustain the cohort's future. In conclusion, NHS is well-positioned to continue cutting-edge research to reduce cancer morbidity and mortality. With the previous investment from NIH and investigators, the incremental costs of continuing this cohort are modest in relation to the uniquely valuable findings that will emerge in the coming 5 years.

描述（由申请人提供）：这是支持原始护士健康研究（NHS）基础设施的UIVII应用程序。 NHS始于1976年，有121,700名妇女，并在37年内积累了19个问卷的数据。随访仍然约为90％。大量的行为数据与多个生物特异性收集相结合，包括血液，脚趾甲，尿液，颊细胞和肿瘤组织，始于1.983，从很大一部分女性开始，为研究癌症预防，病因和生存提供了无与伦比的资源。通过反复的问卷邮件以及持续确定癌症发病率和死亡率的NHS持续随访将允许进行重要的新研究。随着队列的成熟（现在的女性现在已有66岁以上，在癌症发生率的高峰时代），我们建议将重点放在两个总体主题中。首先，我们建议扩大癌症生存研究的基础设施，包括癌症患者的持续时间和生活质量。诊断前后的癌症患者的多年表征将使我们能够区分癌症的原因和后果及其治疗。其次，我们建议改善基础设施，以支持我们研究的系统生物学方法，将问卷数据与DNA，血液，肿瘤组织和其他生物标本中的生物标志物相结合；此类研究同时整合了多个“系统”，包括行为，基因组学，转录组学，代谢组学等，可能会阐明癌症的新机制。我们大量且越来越多的事件癌症病例，以及问卷和生物标本的独特组合，是进行此类综合研究的必要条件。 Specifically, our Aims include new collection of quality of life data, new (collection of tumor tissue (resulting in tissue collections, across 17 cancer sites), improved dat management/statistical support for "big data" analyses, and enhanced infrastructure for data sharing (the NHS resource is already extensively utilized - we have provided access to >75 external investigators in the past 5-6 years and 27 NCI cancer consortia). The NHS structure将高级领导者的漫长经验与几个发展中的领导者的支持是有目的的，以保持领导能力，以维持同伙的未来。 未来5年。